Hostname: page-component-745bb68f8f-s22k5 Total loading time: 0 Render date: 2025-01-15T07:05:46.596Z Has data issue: false hasContentIssue false
  • English
  • Français

A Multicenter Study on Optimizing Piperacillin-Tazobactam Use: Lessons on Why Interventions Fail

Published online by Cambridge University Press:  02 January 2015

Robert P. Gaynes ,
Carolyn V. Gould ,
Jonathan Edwards ,
Theresa L. Antoine ,
Henry M. Blumberg ,
Kathryn DeSilva ,
Mark King ,
Alice Kraman ,
Jan Pack  and
Bruce Ribner
...Show all authors
Robert P. Gaynes*
Affiliation:
Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA Atlanta Veterans' Affairs Medical Center, Atlanta, GA
Carolyn V. Gould
Affiliation:
Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA
Jonathan Edwards
Affiliation:
Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA
Theresa L. Antoine
Affiliation:
Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA
Henry M. Blumberg
Affiliation:
Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA Epidemiology Department, Grady Memorial Hospital, Atlanta, GA
Kathryn DeSilva
Affiliation:
Atlanta Veterans' Affairs Medical Center, Atlanta, GA
Mark King
Affiliation:
Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA Epidemiology Department, Grady Memorial Hospital, Atlanta, GA
Alice Kraman
Affiliation:
Emory Crawford Long Hospital, Atlanta, GA
Jan Pack
Affiliation:
Emory University Hospital, Atlanta, GA
Bruce Ribner
Affiliation:
Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA Emory University Hospital, Atlanta, GA
Ulrich Seybold
Affiliation:
Medizinische Poliklinik, Ludwig-Maximilians-University, Munich, Germany
James Steinberg
Affiliation:
Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA Emory Crawford Long Hospital, Atlanta, GA
John A. Jernigan
Affiliation:
Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA
*
Centers for Disease Control and Prevention, 1600 Clifton Road NE, Mailstop A-24, Atlanta, GA 30333 ([email protected])
Get access Rights & Permissions [Opens in a new window]

Abstract

We examined interventions to optimize piperacillin-tazobactam use at 4 hospitals. Interventions for rotating house staff did not affect use. We could target empiric therapy in only 35% of cases. Because prescribing practices seemed to be institution specific, interventions should address attitudes of local prescribers. Interventions should target empiric therapy and ordering of appropriate cultures.

Type
Concise Communications
Information
Infection Control & Hospital Epidemiology , Volume 30 , Issue 8 , August 2009 , pp. 794 - 796
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2009

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Centers for Disease Control and Prevention NNIS System. National Nosocomial Infections Surveillance (NNIS) system report, data summary from January 1992 through June 2003, issued August 2003. Am J Infect Control 2003;31:481–498.CrossRefGoogle Scholar
2.Antoine, TL, Curtis, AB, Blumberg, HM, et al.Knowledge, attitudes, and behaviors regarding piperacillin-tazobactam prescribing practices: results from a multicenter study. Infect Control Hosp Epidemiol 2006;27:1274–1277.CrossRefGoogle ScholarPubMed
3.Evans, RRS, Classen, DC, Pestotnik, SL, Lundsgaarde, HP, Burke, JP. Improving empiric antibiotic selection using computer decision support. Arch Intern Med 1994;154:878–884.CrossRefGoogle ScholarPubMed
4.Pestotnik, SL, Classen, DC, Evans, RS, Burke, JP. Implementing antibiotic practice guidelines through computer-assisted decision support: clinical and financial outcomes. Ann Intern Med 1996;124:884–890.Google Scholar
5.Sellors, J, Kaczorowski, J, Sellors, C, et al.A randomized controlled trial of a pharmacist consultation program for family physicians and their elderly patients. CMAJ 2003;169:17–22.Google Scholar
6.Arnold, FW, McDonald, LC, Newman, D, Smith, RS, Ramirez, JA. Improving antimicrobial use: longitudinal assessment of an antimicrobial team including a clinical pharmacist. J Manag Care Pharm 2004;10:152–158.Google ScholarPubMed
7.Paskovaty, A, Pflomm, JM, Myke, N, Seo, SK. A multidisciplinary approach to antimicrobial stewardship: evolution into the 21st century. Int J Antimicrob Agents 2005;25:1–10.CrossRefGoogle Scholar
8.Eccles, M, Grimshaw, J, Steen, N, et al.The design and analysis of a randomised controlled trial to evaluate computerised decision support in primary care: the COGENT Study. Fam Pract 2000;17:180–186.CrossRefGoogle ScholarPubMed