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Moxifloxacin Therapy as a Risk Factor for Clostridium difficile–Associated Disease During an Outbreak: Attempts to Control a New Epidemic Strain

Published online by Cambridge University Press:  02 January 2015

Priscilla Biller ,
Beth Shank ,
Leah Lind ,
Meghan Brennan ,
Lisa Tkatch ,
George Killgore ,
Angela Thompson  and
L. Clifford McDonald
Priscilla Biller
Affiliation:
Holy Spirit Hospital, Camp Hill, Pennsylvania
Beth Shank
Affiliation:
Holy Spirit Hospital, Camp Hill, Pennsylvania
Leah Lind
Affiliation:
Pennsylvania Department of Health, Harrisburg, Pennsylvania
Meghan Brennan
Affiliation:
Centers for Disease Control and Prevention, Atlanta, Georgia
Lisa Tkatch
Affiliation:
Holy Spirit Hospital, Camp Hill, Pennsylvania
George Killgore
Affiliation:
Centers for Disease Control and Prevention, Atlanta, Georgia
Angela Thompson
Affiliation:
Centers for Disease Control and Prevention, Atlanta, Georgia
L. Clifford McDonald*
Affiliation:
Centers for Disease Control and Prevention, Atlanta, Georgia
*
Centers for Disease Control and Prevention, 1600 Clifton Road, MS A35, Atlanta, GA 30333 ([email protected])
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Abstract

An outbreak of Clostridium difficile-associated disease (CDAD) caused by the epidemic North American pulsed-field gel electrophoresis type 1 (NAP1) strain began after a formulary change from levofloxacin to moxifloxacin. Cases of CDAD were associated with moxifloxacin use, but a formulary change back to levofloxacin failed to reduce rates of disease. Substituting use of one fluoroquinolone with use of another without also controlling the overall use of drugs from this class is unlikely to control outbreaks caused by the NAP1 strain of C. difficile.

Type
Concise Communication
Information
Infection Control & Hospital Epidemiology , Volume 28 , Issue 2 , February 2007 , pp. 198 - 201
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2007

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