Hostname: page-component-586b7cd67f-gb8f7 Total loading time: 0 Render date: 2024-11-24T21:45:35.521Z Has data issue: false hasContentIssue false

Minimizing Antimicrobial Resistance in Hospital Bacteria: Can Switching or Cycling Drugs Help?

Published online by Cambridge University Press:  02 January 2015

John E. McGowan Jr.*
Affiliation:
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, and the Clinical Microbiology Laboratory, Grady Memorial Hospital, Atlanta, Georgia
*
Director, Clinical Microbiology (Box 248), Grady Memorial Hospital, 80 Butler Street, Atlanta, GA 30335
Rights & Permissions [Opens in a new window]

Abstract

Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Editorial
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1986

References

1. McGowan, JE Jr: Changing etiology of nosocomial bacteremia and fungemia and other hospital-acquired infections. Rev Infect Dis 1985; 7(Suppl 3):S357-S370.Google Scholar
2. McGowan, JE Jr: Antimicrobial resistance in hospital organisms and its relation to antibiotic use. Rev Infect Dis 1983; 5:10331048.CrossRefGoogle ScholarPubMed
3. McGowan, JE Jr: Is antimicrobial resistance in hospital microorganisms related to antibiotic use? Bull NY Acad Med {in press).Google Scholar
4. Levin, S, Karakusis, PH: Future trends in aminoglycoside therapy. Am J Med 1986; 80(Suppl 6B):190194.Google Scholar
5. Berk, SL, Alvarez, S, Ortega, G, et al: Clinical and microbiologic consequences of amikacin use during a 42-month period. Arch Intern Med 1986; 146:538541.Google Scholar
6. Yurasek, MC, Wang, WL, Mostow, SR: Reduction in gentamicin resistance among gram-negative bacilli with the exclusive use of amikacin. Clin Res 1981; 29:92A (abstract).Google Scholar
7. Moody, MM, deJongh, CA, Schimpff, SC, et al: Long term amikacin use: Effects on aminoglycoside susceptibility patterns of gram-negative bacilli. JAMA 1982; 248:11991202.Google Scholar
8. Wielunsky, E, Drucker, M, Cohen, T, et al: Replacement of gentamicin by amikacin as a means of decreasing gentamicin resistance of gram-negative rods in a neonatal intensive care unit. Isr J Med Sci 1983; 19:10061008.Google Scholar
9. Cross, AS, Opal, S, Kopecko, DJ: Progressive increase in antibiotic resistance of gram-negative bacterial isolates: Walter Reed Hospital, 1976 to 1980: Specific analysis of gentamicin, tobramycin, and amikacin resistance. Arch Intern Med 1983; 143:20752080.CrossRefGoogle ScholarPubMed
10. Betts, RF, Valenti, WM, Chapman, SW, et al: Five-year surveillance of aminogly-coside usage in a university hospital. Ann Intern Med 1984; 100:219222.CrossRefGoogle ScholarPubMed
11. Saravolatz, LD, Arking, L, Pohlod, D, et al: An outbreak of gentamicin-resistant Klebsiella pneumoniae: Analysis of control measures. Infect Control 1984; 5:7984.CrossRefGoogle ScholarPubMed
12. Shulman, ST, Yogev, R: Treatment of pediatric infections with amikacin as firstline aminoglycoside. Am J Med 1985; 79(Suppl 1A):4350.Google Scholar
13. Levine, JF, Maslow, MJ, Leibowitz, RE, et al: Amikacin-resistant gram-negative bacilli: Correlation of occurrence with amikacin use. J Infect Dis 1985; 151:295300.Google Scholar
14. Gerding, DN, Larson, TA: Aminoglycoside resistance in gram-negative.bacilli during increased amikacin use. Am J Med 1985; 79(Suppl 1A):l7.Google ScholarPubMed
15. Young, EJ, Sewell, CM, Koza, MA, et al: Antibiotic resistance patterns during aminoglycoside restriction. Am J Med Sci 1985; 290:223227.Google Scholar
16. Acar, JF, Goldstein, FW, Menard, R, et al: Strategies in aminoglycoside use and impact on resistance. Am J Med 1986; 80(Suppl 6B):8287.Google Scholar
17. Saavedra, S, Vera, D, Ramirez-Ronda, CH: Susceptibility of aerobic gram-negative bacilli to aminoglycosides—Effects of 45 months of amikacin as first-line aminoglycoside therapy. Am J Med 1986; 80(Suppl 6B):6570.Google Scholar
18. Ruiz-Palacios, GM, Ponce de Leon, S, Sifuentes, J, et al: Control of emergence of multi-resistant gram-negative bacilli by exclusive use of amikacin. Am J Med 1986; 80(Suppl 6B):7175.CrossRefGoogle ScholarPubMed
19. Van Landuyt, HW, Boelaert, J, Glibert, B, et al: Surveillance of aminoglycoside resistance—European data. Am J Med 1986; 80(Suppl 6B):76-81.Google Scholar
20. Gerding, DN, Larson, TA: Resistance surveillance programs and the incidence of gram-negative bacillary resistance to amikacin from 1967 to 1985. Am J Med 1986; 80(Suppl 6B):2228.CrossRefGoogle ScholarPubMed
21. Young, LS, Hindler, J: Aminoglycoside resistance: A worldwide perspective. Am J Med 1986; 80(Suppl 6B):1521.Google Scholar
22. Mayer, KH: Review of epidemic aminoglycoside resistance worldwide. Am J Med 1986; 80(Suppl 6B):5664.Google Scholar
23. Bryan, CS, Parker, E, Schoenlein, PV, et al: Plasmid-mediated antibiotic resistance in a changing hospital environment: Efficacy of control measures. Am J Infect Control 1980; 8:6571.Google Scholar
24. John, JF Jr, Rubens, CE, Farrar, WE Jr: Characteristics of gentamicin resistance in nosocomial infections. Am J Med Sci 1980; 279:2530.Google Scholar
25. Weinstein, RA, Nathan, C, Gruensfelder, R, et al: Endemic aminoglycoside resistance in gram-negative bacilli: Epidemiology and mechanism. J Infect Dis 1980; 141:338345.CrossRefGoogle Scholar
26. Lane, MM, Parker, DE, Flournoy, DJ: Trends in bacterial susceptibility to antimicrobial agents. Chemotherapy 1985; 31:433439.CrossRefGoogle ScholarPubMed
27. Mickelsen, PA, Plorde, JJ, Gordon, KP, et al: Instability of antibiotic resistance in a strain of Staphylococcus epidermidis isolated from an outbreak of prosthetic valve endocarditis. J Infect Dis 1985; 152:5058.Google Scholar
28. Cherubin, CE, Eng, RHK, Dabernat, H, Lareng, MB: Comparison of antibiotic resistance of gram-negative bacilli with beta-lactam and aminoglycoside antibiotics. Diagn Microbiol Infect Dis 1986; 4:153159.CrossRefGoogle ScholarPubMed
29. Daschner, F, et al: Antibiotic resistance in intensive care unit areas. Infect Control 1983; 4:382387.CrossRefGoogle ScholarPubMed
30. Shimizu, K, Kumada, T, Hsieh, W, et al: Comparison of aminoglycoside resistance patterns in Japan, Formosa, and Korea, Chile, and the United States. Antimicrob Agents Chemother 1985; 28:282288.CrossRefGoogle ScholarPubMed
31. Goossens, H, Van Laethem, Y, Levy, J, et al: Predicting gentamicin resistance from annual usage in hospital. Lancet 1986; 2:804805.Google Scholar
32. Magnussen, CR, Jacobson, MT: Longitudinal analysis of endemic gentamicin and tobramycin-resistant gram-negative bacilli in a community hospital. Infect Control 1984; 5:8892.Google Scholar
33. Van Nhieu, GT, Goldstein, FW, Pinto, ME, et al: Transfer of amikacin resistance by closely related plasmids in members of the family Enterobacteriaceae isolated in Chile. Antimicrob Agents Chemother 1986; 29:833837.Google Scholar
34. Tolmasky, ME, Roberts, M, Woloj, M, et al: Molecular cloning of amikacin resistance determinants from a Klebsiella pneumoniae plasmid. Antimicrob Agents Chemother 1986; 30:315320.Google Scholar
35. Phillips, I, King, A, Shannon, K: Prevalence and mechanisms of aminoglycoside resistance. A ten-year study. Am J Med 1986; 80(Suppl 6B):4855.CrossRefGoogle ScholarPubMed
36. Lee, SC, Gerding, DN, Cleary, PP: Hospital distribution, persistence, and reintroduction of related gentamicin R plasmids. Antimicrob Agents Chemother 1986; 29:654659.Google Scholar
37. Larson, TA, Garrett, CR, Gerding, DN: Frequency of aminoglycoside 6'-Nacetyltransferase among Serratia species during increased use of amikacin in the hospital. Antimicrob Agents Chemother 1986; 30:176178.CrossRefGoogle ScholarPubMed
38. Isenberg, HD, Berkman, JI: The role of drug-resistant and drug-selected bacteria in nosocomial disease. Ann NY Acad Sci 1971; 182:5258.Google Scholar
39. Gardner, DA, Lorian, V: Bacterial susceptibility to antibiotics remains virtually stable. Antimicrobic Newsletter 1985; 2:913.Google Scholar
40. Manu, P: Empiric use of aminoglycosides in hospitals. Ann Intern Med 1984; 100:919.Google Scholar
41. Sanders, CC, Sanders, WE Jr: Microbial resistance to newer generation betalactam antibiotics: Clinical and laboratory implications. J Infect Dis 1985; 151:399406.CrossRefGoogle ScholarPubMed
42. Woloj, M, Tolmasky, ME, Roberts, MC, et al: Plasmid-encoded amikacin resistance in multiresistant strains of Klebsiella pneumoniae isolated from neonates with meningitis. Antimicrob Agents Chemother 1986; 29:315319.Google Scholar
43. Neu, HC: Antimicrobial activity, bacterial resistance, and antimicrobial pharmacology: Is it possible to use new agents cost-effectively? Am J Med 1985; 78(Suppl6B):1722.CrossRefGoogle ScholarPubMed
44. Aldis, WL, Cowan, D: Cost-effectiveness of antibiotic use. JAMA 1984; 252:3252.Google Scholar
45. Jorgensen, JH: Susceptibility test methods which may be able to predict the emergence of resistance to newer beta-lactam antibiotics. Chemioterapia 1985; 4:713.Google Scholar
46. Quintiliani, R, Klimek, JJ, Nightingale, CH: Restriction policies for therapy with combination antibiotics. J Infect Dis 1986; 153:645647.Google Scholar
47. Schaberg, DR, Power, G, Betzold, J, et al: Conjugative R plasmids in antimicrobial resistance of Staphylococcus aureus causing nosocomial infections. J Infect Dis 1985; 152:4349.Google Scholar