Hostname: page-component-cd9895bd7-gvvz8 Total loading time: 0 Render date: 2024-12-23T08:07:12.282Z Has data issue: false hasContentIssue false
  • English
  • Français

Microbiologic and Clinical Epidemiologic Characteristics of the Chicago Subset of a Multistate Outbreak of Serratia marcescens Bacteremia

Published online by Cambridge University Press:  02 January 2015

Monica K. Sikka ,
Mary K. Hayden ,
Stacy Pur ,
John Segreti ,
Alan A. Harris ,
Robert A. Weinstein  and
Gordon Trenholme
Monica K. Sikka
Affiliation:
Section of Infectious Diseases, Department of Medicine, Rush University Medical Center, Chicago, Illinois
Mary K. Hayden*
Affiliation:
Section of Infectious Diseases, Department of Medicine, Rush University Medical Center, Chicago, Illinois
Stacy Pur
Affiliation:
Section of Infectious Diseases, Department of Medicine, Rush University Medical Center, Chicago, Illinois
John Segreti
Affiliation:
Section of Infectious Diseases, Department of Medicine, Rush University Medical Center, Chicago, Illinois
Alan A. Harris
Affiliation:
Section of Infectious Diseases, Department of Medicine, Rush University Medical Center, Chicago, Illinois
Robert A. Weinstein
Affiliation:
Section of Infectious Diseases, Department of Medicine, Rush University Medical Center, Chicago, Illinois Division of Infectious Diseases, Department of Medicine, Stroger (Cook County) Medical Center, Chicago, Illinois
Gordon Trenholme
Affiliation:
Section of Infectious Diseases, Department of Medicine, Rush University Medical Center, Chicago, Illinois
*
Rush University Medical Center, 1653 West Congress Parkway, Chicago, IL 60612 ([email protected])
Get access Rights & Permissions [Opens in a new window]

Extract

We describe 22 patients from a multistate outbreak of Serraría marcescens bacteremia that was linked to contaminated prefilled syringes of heparin and saline supplied by 1 manufacturer. Contents of unused syringes were cultured in pools samples from 25 (5.3%) of 472 syringes grew S. marcescens. Despite good clinical outcomes overall, patients had substantial morbidity.

Type
Concise Communications
Information
Infection Control & Hospital Epidemiology , Volume 31 , Issue 11 , November 2010 , pp. 1191 - 1193
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2010

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Gersham, MD, Kennedy, DJ, Noble-Wang, J, et al.Multistate outbreak of Pseudomonas fluorescens bloodstream infection after exposure to contaminated heparinized saline flush prepared by a compounding pharmacy. Clin Infect Dis 2008;47:1372–1379.Google Scholar
2.Blossom, DB, Kallen, AJ, Patel, PR, et al.Outbreak of adverse reactions associated with contaminated heparin. N Engl J Med 2008;359:2674–2684.CrossRefGoogle ScholarPubMed
3.Blossom, D, Noble-Wang, J, Su, J, et al.Multistate outbreak of Serratia marcescens bloodstream infections caused by contamination of prefilled heparin and isotonic sodium chloride solution syringes. Arch Intern Med 2009;169(18):1705–1711.CrossRefGoogle ScholarPubMed
4.Su, JR, Blossom, DB, Chung, W, et al.Epidemiologic investigation of a 2007 outbreak of Serratia marcescens bloodstream infection in Texas caused by contamination of syringes prefilled with heparin and saline. Infect Control Hosp Epidemiol 2009;30(6):593–595.Google Scholar
5.Matushek, MG, Bonten, MJ, Hayden, MK. Rapid preparation of bacterial DNA for pulsed-field gel electrophoresis. J Clin Microbiol 1996;34( 10):2598–2600.Google Scholar
6.Mermel, LA, Alton, M, Bouza, E, et al.Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 update by the Infectious Diseases Society of America. Clin Infect Dis 2009;49(1):1–45.Google Scholar
7.United States Pharmacopeia 26. Rockville, MD: US Pharmacopeial Convention, 2003:2157–2169.Google Scholar