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Large Nosocomial Outbreak Associated with a Norwegian Scabies Index Case Undergoing TNF-α Inhibitor Treatment: Management and Control

Published online by Cambridge University Press:  19 August 2015

Valeria Belvisi
Affiliation:
UOC Malattie Infettive, Ospedale SM Goretti, Università Sapienza, Latina, Italy Dipartimento di Sanità Pubblica e Malattie Infettive, Sapienza Università di Roma, Italy
Giovanni Battista Orsi*
Affiliation:
Dipartimento di Sanità Pubblica e Malattie Infettive, Sapienza Università di Roma, Italy
Cosmo Del Borgo
Affiliation:
UOC Malattie Infettive, Ospedale SM Goretti, Università Sapienza, Latina, Italy
Paolo Fabietti
Affiliation:
UOC Malattie Infettive, Ospedale SM Goretti, Università Sapienza, Latina, Italy
Adriana Ianari
Affiliation:
UOC Rischio Clinico, ASL, Latina, Italy
Francesco Albertoni
Affiliation:
UOC Epidemiologia, ASL, Latina, Italy
Patricia Porcelli
Affiliation:
UOS Malattie Infettive e Prevenzione, ASL Latina, Italy
Concetta Potenza
Affiliation:
UOC Dermatologia, Università Sapienza, Terracina, Italy
Claudio Maria Mastroianni
Affiliation:
UOC Malattie Infettive, Ospedale SM Goretti, Università Sapienza, Latina, Italy Dipartimento di Sanità Pubblica e Malattie Infettive, Sapienza Università di Roma, Italy
*
Address correspondence to Giovanni B Orsi, Dipartimento di Sanità Pubblica e Malattie Infettive, Sapienza Università di Roma, P.le Aldo Moro 5, 00185 Roma, Italy ([email protected]).

Abstract

We describe a large outbreak associated with a crusted (Norwegian) scabies case in an immunocompromised patient following treatment with TNF-α inhibitor (adalimumab) for psoriasis arthritis. The increasing use of TNF-α inhibitors should induce clinicians to consider this serious parasitic infection when evaluating skin rashes in patients receiving biologic therapies.

Infect. Control Hosp. Epidemiol. 2015;36(11):1358–1360

Type
Concise Communications
Copyright
© 2015 by The Society for Healthcare Epidemiology of America. All rights reserved 

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References

REFERENCES

1. Diaz, JH. Scabies. In: Mandell GL, Bennett JE, Dolin R, eds. Principles and Practice of Infectious Disease. Philadelphia, PA: Churchill Livingstone Elsevier; 2010.Google Scholar
2. Del Borgo, C, Belvisi, V, Tieghi, T, Mastroianni, CM. Atypical presentation of crusted (Norwegian) scabies. Infection 2015, Mar 29 (Epub ahead of print).Google ScholarPubMed
3. Khan, A, O’Grady, S, Muller, MP. Rapid control of a scabies outbreak at a tertiary care hospital without ward closure. Am J Infect Control 2012;40:451455.CrossRefGoogle Scholar
4. Lettau, LA. Nosocomial transmission and infection control of parasitic and ectoparasitic diseases. Part III. Ectoparasites/summary and conclusions. Infect Control Hosp Epidemiol 1991;12:179185.CrossRefGoogle ScholarPubMed
5. Vorou, R, Remoudaki, HD, Maltezou, HC. Nosocomial scabies. J Hosp Infect 2007;65:914.CrossRefGoogle ScholarPubMed
6. Singh, JA, Cameron, C, Noorbaloochi, S, et al. Risk of serious infection in biological treatment of patients with rheumatoid arthritis: a systematic review and meta-analysis. Lancet 2015, May 11 (Epub ahead of print).Google Scholar
7. Regnier-Rosencher, E, Farhi, D, Lebrun, A, Salliot, C, Dougados, M, Dupin, N. Factors associated with severe skin infections in patients treated with biologic therapies for inflammatory rheumatic diseases. Dermatology 2012;224:7283.CrossRefGoogle ScholarPubMed
8. Pipitone, MA, Adams, B, Sheth, A, Graham, TB. Crusted scabies in a patient being treated with infliximab for juvenile rheumatoid arthritis. J Am Acad Dermatol 2005;52:719720.CrossRefGoogle Scholar
9. Saillard, C, Darrieux, L. Crusted scabies complicates etanercept therapy in a patient with severe psoriasis. J Am Acad Dermatol 2013;68:e138e139.Google Scholar
10. Buehlmann, M, Beltraminelli, H, Strub, C, et al. Scabies outbreak in an intensive care unit with 1,659 exposed individuals—key factors for controlling the outbreak. Infect Control Hosp Epidemiol 2009;30:354360.Google Scholar