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A Large Epidemic of Hepatitis B in Serbia: An Integrated Model for Outbreak Investigations in Healthcare Settings

Published online by Cambridge University Press:  10 May 2016

Simone Lanini ,
Gorana Ćosić ,
Stefano Menzo ,
Vincenzo Puro ,
Predrag Đurić ,
Anna Rosa Garbuglia ,
Vesna Milošević ,
Tatjana Karać ,
Maria Rosaria Capobianchi  and
Giuseppe Ippolito
Simone Lanini*
Affiliation:
National Institute for Infectious Diseases, Istituto Nazionale per le Malattie Infettive–Lazzaro Spallanzani, Rome, Italy
Gorana Ćosić
Affiliation:
University of Novi Sad, Faculty of Medicine/Institute of Public Health of Vojvodina, Autonomous Province of Vojvodina, Serbia
Stefano Menzo
Affiliation:
Università Politecnica delle Marche, Ancona, Italy
Vincenzo Puro
Affiliation:
National Institute for Infectious Diseases, Istituto Nazionale per le Malattie Infettive–Lazzaro Spallanzani, Rome, Italy
Predrag Đurić
Affiliation:
University of Novi Sad, Faculty of Medicine/Institute of Public Health of Vojvodina, Autonomous Province of Vojvodina, Serbia
Anna Rosa Garbuglia
Affiliation:
National Institute for Infectious Diseases, Istituto Nazionale per le Malattie Infettive–Lazzaro Spallanzani, Rome, Italy
Vesna Milošević
Affiliation:
University of Novi Sad, Faculty of Medicine/Institute of Public Health of Vojvodina, Autonomous Province of Vojvodina, Serbia
Tatjana Karać
Affiliation:
Center of Disease Control and Prevention, Institute of Public Health, Autonomous Province of Vojvodina, Serbia
Maria Rosaria Capobianchi
Affiliation:
National Institute for Infectious Diseases, Istituto Nazionale per le Malattie Infettive–Lazzaro Spallanzani, Rome, Italy
Giuseppe Ippolito
Affiliation:
National Institute for Infectious Diseases, Istituto Nazionale per le Malattie Infettive–Lazzaro Spallanzani, Rome, Italy
*
National Institute for Infectious Diseases, INMI–Lazzaro Spallanzani, Via Portuense, 292 00149 Rome, Italy ([email protected]).
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Abstract

We report a comprehensive approach for outbreak investigations, including cluster analysis (Bernoulli model), an algorithm to build inferential models, and molecular techniques to confirm cases. Our approach may be an interesting tool to best exploit the large amount of unsystematically collected information available during outbreak investigations in healthcare settings.

Infect Control Hosp Epidemiol 2014;35(6):732–735

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 35 , Issue 6 , 01 June 2014 , pp. 732 - 735
Copyright
© 2014 by The Society for Healthcare Epidemiology of America. All rights reserved.

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Footnotes

a

These authors contributed equally to this article.

References

1. Siegel, JD, Rhinehart, E, Jackson, M, Chiarello, L; Health Care Infection Control Practices Advisory Committee. 2007 Guideline for isolation precautions: preventing transmission of infectious agents in healthcare settings. Am J Infect Control 2007;35:S65–S164.Google Scholar
2. Lanini, S, Puro, V, Lauria, FN, et al. Patient to patient transmission of hepatitis B virus: a systematic review of reports on outbreaks between 1992 and 2007. BMC Med 2009;7:15.Google Scholar
3. National Cancer Institute. Common Terminology Criteria for Adverse Events v4.0. 2009 ed.Google Scholar
4. Kulldorff, M. SaTScan user guide for version 9.2. October 2013. http://www.satscan.org/techdoc.html.Google Scholar
5. Hirji, KF, Mehta, CR, Patel, NR. Computing distributions for exact logistic regression. J Am Stat Assoc 1987;82(400):1110–1117.Google Scholar
6. Mindikoglu, AL, Regev, A, Schiff, ER. Hepatitis B virus reactivation after cytotoxic chemotherapy: the disease and its prevention. Clin Gastroenterol Hepatol 2006;4(9):1076–1081.Google Scholar
7. Rodriguez-Frias, EA, Lee, WM. Cancer chemotherapy I: hepatocellular injury. Clin Liver Dis 2007;11(3):641–662.Google Scholar
8. Lazarevic, I, Cupic, M, Delic, D, Svirtlih, NS, Simonovic, J, Jovanovic, T. Distribution of HBV genotypes, subgenotypes and HBsAg subtypes among chronically infected patients in Serbia. Arch Virol 2007;152(11):2017–2025.Google Scholar
9. Heymann, DL. Control of Communicable Diseases Manual. 19th ed. Washington, DC: American Public Health Association, 2008.Google Scholar
10. Dunn, C, Peppa, D, Khanna, P, et al. Temporal analysis of early immune responses in patients with acute hepatitis B virus infection. Gastroenterology 2009;137(4):1289–1300.Google Scholar