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Intranasal octenidine for methicillin-resistant Staphylococcus aureus (MRSA) carriers and universal octenidine bathing reduced MRSA acquisition in an acute-care general ward

Published online by Cambridge University Press:  16 July 2021

Aung-Hein Aung ,
Win Mar Kyaw ,
Yee Kiat Heng ,
Hong Liang Tey ,
Brenda Ang  and
Angela Chow Open the ORCID record for Angela Chow [Opens in a new window]
Aung-Hein Aung
Affiliation:
Department of Clinical Epidemiology, Office of Clinical Epidemiology, Analytics and Knowledge, Tan Tock Seng Hospital, Singapore
Win Mar Kyaw
Affiliation:
Department of Clinical Epidemiology, Office of Clinical Epidemiology, Analytics and Knowledge, Tan Tock Seng Hospital, Singapore
Yee Kiat Heng
Affiliation:
National Skin Centre, Singapore
Hong Liang Tey
Affiliation:
National Skin Centre, Singapore Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore Yong Loo Lin School of Medicine, National University of Singapore, Singapore
Brenda Ang
Affiliation:
Department of Infection Prevention and Control, Tan Tock Seng Hospital, Singapore
Angela Chow*
Affiliation:
Department of Clinical Epidemiology, Office of Clinical Epidemiology, Analytics and Knowledge, Tan Tock Seng Hospital, Singapore Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore
*
Author for correspondence: Angela Chow, E-mail: [email protected]
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Abstract

In this quasi-experimental before-and-after study in a methicillin-resistant staphylococcus aureus (MRSA) high-prevalence acute-care dermatology ward from August 2016 to November 2018, patients admitted during intervention period who received additional topical intranasal octenidine were 63% less likely to acquire MRSA than those receiving universal daily octenidine bathing alone during baseline period (aOR, 0.37; 95% CI, 0.14–0.98).

Type
Concise Communication
Information
Infection Control & Hospital Epidemiology , Volume 43 , Issue 11 , November 2022 , pp. 1701 - 1704
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Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America

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References

Su, CH, Chang, SC, Yan, JJ, Tseng, SH, Chien, LJ, Fang, CT. Excess mortality and long-term disability from healthcare-associated Staphylococcus aureus infections: a population-based matched cohort study. PLoS One 2013;8:e71055.CrossRefGoogle ScholarPubMed
Matsumoto, K, Takeuchi, S, Uehara, Y, et al. Transmission of methicillin-resistant Staphylococcus aureus in an acute care hospital in Japan. J Gen Fam Med 2018;20:13–18.CrossRefGoogle Scholar
Simor, AE. Staphylococcal decolonisation: an effective strategy for prevention of infection? Lancet Infect Dis 2011;11:952–962.CrossRefGoogle ScholarPubMed
Krishna, BV, Gibb, AP. Use of octenidine dihydrochloride in meticillin-resistant Staphylococcus aureus decolonisation regimens: a literature review. J Hosp Infect 2010;74:199–203.CrossRefGoogle ScholarPubMed
Hübner, NO, Siebert, J, Kramer, A. Octenidine dihydrochloride, a modern antiseptic for skin, mucous membranes and wounds. Skin Pharmacol Physiol 2010;23:244–258.CrossRefGoogle ScholarPubMed
Chow, A, Hon, PY, Tin, G, Zhang, W, Poh, BF, Ang, B. Intranasal octenidine and universal antiseptic bathing reduce methicillin-resistant Staphylococcus aureus (MRSA) prevalence in extended care facilities. Epidemiol Infect 2018;146:2036–2041.CrossRefGoogle ScholarPubMed
Chow, A, Wong, J, Zhang, W, Poh, BF, Ang, B. Intranasal octenidine and universal chlorhexidine bathing can reduce meticillin-resistant Staphylococcus aureus acquisition in an extended care facility in Singapore. J Hosp Infect 2020;105:628–631.CrossRefGoogle Scholar
Gastmeier, P, Kämpf, KP, Behnke, M, Geffers, C, Schwab, F. An observational study of the universal use of octenidine to decrease nosocomial bloodstream infections and MDR organisms. J Antimicrob Chemother 2016;71:2569–2576.CrossRefGoogle ScholarPubMed
Baier, C, Ipaktchi, R, Schwab, F, et al. Universal decolonization with octenidine: first experiences in a tertiary burn intensive care unit. Burns Open 2019;3:8–11.CrossRefGoogle Scholar
Harris, PN, Le, BD, Tambyah, P, et al. Antiseptic body washes for reducing the transmission of methicillin-resistant Staphylococcus aureus: a cluster crossover study. Open Forum Infect Dis 2015;2:ofv051.CrossRefGoogle ScholarPubMed
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