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Intervention to Discontinue Parenteral Antimicrobial Therapy in Hospitalized Patients with Urinary Tract Infection, Skin and Soft Tissue Infection, or No Evident Infection

Published online by Cambridge University Press:  21 June 2016

N. Joel Ehrenkranz ,
Debra E. Nerenberg ,
Kenneth C. Slater  and
James M. Shultz
N. Joel Ehrenkranz*
Affiliation:
Florida Consortium for Infection Control, South Miami, Florida
Debra E. Nerenberg
Affiliation:
Florida Consortium for Infection Control, South Miami, Florida
Kenneth C. Slater
Affiliation:
Florida Consortium for Infection Control, South Miami, Florida
James M. Shultz
Affiliation:
Florida Consortium for Infection Control, South Miami, Florida
*
5901 SW 74th St., Suite 300, South Miami, FL 33143
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Abstract

Objectives:

In a previous study, we found that unsolicited recommendations to physicians of medically stable patients with pneumonia to suspend parenteral antimicrobials shortened hospital length of stay (LOS) significantly. In this study, we made similar recommendations to physicians treating patients with different indications for parenteral antimicrobials, to examine the effect on LOS.

Methods:

A nurse-interventionist presented randomly assigned physicians with nonconfrontational suggestions to discontinue parenteral antimicrobials by substituting comparable oral antimicrobials or stopping treatment. Patients were being treated for urinary tract infection, skin infection, or no evident infection. Blinded observers evaluated in-hospital and 30-day postdischarge patient courses. Methodologies were identical to the previous study.

Results:

There were 70 physician-patient episodes (49 intervened episodes, 21 control episodes). In 44 episodes (90%), compliant physicians discontinued parenteral antimicrobials. Compared to a median postrandomization LOS of 2.5 days (range, 0 to 40.5) for 21 patients of control physicians, the corresponding LOS for 44 patients of compliant physicians was two days (range, 0 to 8; P= 1.0), and for five patients of noncompliant physicians, five days (range, 3 to 11; P= 0.04).

The combined occurrence of all adverse events detected in this and the previous study was 11% for patients of control physicians, compared to 14% for patients of compliant physicians (P= 0.2), and 19% for patients of noncompliant physicians (P<0.05).

Conclusions:

For patients of compliant physicians hospitalized with urinary tract infection, skin and soft tissue infection, or no evident infection, cessation of parenteral antimicrobials did not significantly shorten LOS, due to brief LOS of patients of control physicians. Patients of noncompliant physicians experienced more adverse events and prolonged LOS. The appropriateness of routine continuous use of parenteral antimicrobials in medically stable inpatients is questioned.

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 14 , Issue 9 , September 1993 , pp. 517 - 522
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1993

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References

1. Ehrenkranz, NJ, Nerenberg, DE, Shultz, JM, Slater, KC. Intervention to discontinue parenteral antimicrobial therapy in patients hospitalized with pulmonary infections: effect on shortening patient stay. Infect Control Hosp Epidemiol 1992;13:21–32.CrossRefGoogle ScholarPubMed
2. Dajani, AS et al. Prevention of bacterial endocarditis. JAMA 1990;264:2919–2922.CrossRefGoogle ScholarPubMed
3. Norden, CW. Antibiotic prophylaxis in orthopedic surgery. Rev Infect Dis 1991;13(suppl 10):S842–S846.CrossRefGoogle ScholarPubMed
4. Ehrenkranz, NJ. South Florida Hospital Consortium for Infection Control: structure and function. Am J Infect Control 1987;15:36–41.CrossRefGoogle Scholar
5. Williams, RR, Gross, PA, Levine, JF. Costcontainment of the second-generation cephalosporins by prospective monitoring at a community teaching hospital. Arch Intern Med 1985;145:1978–1981.CrossRefGoogle Scholar
6. Fleiss, JL. Statistical Methods for Rates and Proportions. 2nd ed. New York, NY: John Wiley and Sons; 1981:260.Google Scholar
7. Landfeld, CS, Anderson, PA. Guideline-based consultation to prevent anticoagulant-related bleeding. Ann Intern Med 1992;116:829–837.CrossRefGoogle Scholar