Hostname: page-component-745bb68f8f-s22k5 Total loading time: 0 Render date: 2025-01-15T07:43:08.705Z Has data issue: false hasContentIssue false
  • English
  • Français

Integron Class 1 Reservoir among Highly Resistant Gram-Negative Microorganisms Recovered at a Dutch Teaching Hospital

Published online by Cambridge University Press:  02 January 2015

Marlies J. Mooij ,
Ina Willemsen ,
Marihe Lobbrecht ,
Christina Vandenbroucke-Grauls ,
Jan Kluytmans  and
Paul H. M. Savelkoul
Marlies J. Mooij
Affiliation:
Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, the Netherlands
Ina Willemsen
Affiliation:
Laboratory for Microbiology and Infection Control, Amphia Hospital, Breda, the Netherlands
Marihe Lobbrecht
Affiliation:
Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, the Netherlands
Christina Vandenbroucke-Grauls
Affiliation:
Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, the Netherlands
Jan Kluytmans
Affiliation:
Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, the Netherlands Laboratory for Microbiology and Infection Control, Amphia Hospital, Breda, the Netherlands
Paul H. M. Savelkoul*
Affiliation:
Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, the Netherlands
*
Department of Medical Microbiology and Infection Control, VU University Medical Center, PO Box 7057, 1007MB Amsterdam, the Netherlands ([email protected])
Get access Rights & Permissions [Opens in a new window]

Abstract

Integrons play an important role in the dissemination of resistance genes among bacteria. Nearly 70% of highly resistant gram-negative bacteria isolated at a tertiary care hospital harbored an integron. Epidemiologic analysis suggests that horizontal gene transfer is an important mechanism of resistance spread and has a greater contribution than cross-transmission to levels of resistance in settings where highly resistant gram-negative bacteria are endemic.

Type
Concise Communications
Information
Infection Control & Hospital Epidemiology , Volume 30 , Issue 10 , October 2009 , pp. 1015 - 1018
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2009

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Kluytmans-Vandenbergh, MF, Kluytmans, JA, Voss, A. Dutch guideline for preventing nosocomial-transmission of highly resistant microorganisms (HRMO). Infection 2005;33:309–313.CrossRefGoogle ScholarPubMed
2.van Vonderen, MG, Gyssens, IC, Hartwig, NG, et al.Optimization of the antibiotic policy in the Netherlands. XI. The national electronic antibiotic guide SWAB-ID for use in hospitals [in Dutch]. Ned Tijdschr Geneeskd 2006;150:2560–2564.Google Scholar
3.Leverstein-van Hall, MA, Paauw, A, Box, ATA, Blok, HEM, Verhoef, J, Fluit, AC. Presence of integron-associated resistance in the community is widespread and contributes to multidrug resistance in the hospital. J Clin Microbiol 2002;40:3038–3040.Google Scholar
4.Mooij, MJ, Schouten, I, Vos, G, et al.Class 1 integrons in ciprofloxacin-resistant Escherichia coli strains from two Dutch hospitals. Clin Microbiol Infect 2005;11:898–902.Google Scholar
5.Willemsen, I, Mooij, MJ, Van der Wiel, M, et al.Highly resistant microorganisms in a teaching hospital: the role of horizontal spread in a setting of endemicity. Infect Control Hosp Epidemiol 2008;29:1110–1117.Google Scholar
6.Leverstein-van Hall, MA, Box, AT, Blok, HE, Paauw, A, Fluit, AC, Verhoef, J. Evidence of extensive interspecies transfer of integron-mediated antimicrobial resistance genes among multidrug-resistant Enterobacteriaceae in a clinical Setting. J Infect Dis 2002;186:49–56.Google Scholar
7.Shoemaker, NB, Vlamakis, H, Hayes, K, Salyers, AA. Evidence for extensive resistance transfer among Bacteroides spp. and among Bacteroides and other genera in the human colon. Appi Environ Miaobiol 2001;67:561–568.CrossRefGoogle ScholarPubMed
8.Leverstein-van Hall, MA, Blok, HE, Paauw, A, et al.Extensive hospital-wide spread of a multidrug-resistant Enterobacter cloacae clone, with late detection due to a variable antibiogram and frequent patient transfer. J Clin Microbiol 2006;44:518–524.Google Scholar
9.Nijssen, S, Florijn, A, Top, J, Willems, R, Fluit, A, Bonten, M. Unnoticed spread of integron-carrying Enterobacteriaceae in intensive care units. Clin Infect Dis 2005;41:1–9.Google Scholar