Hostname: page-component-78c5997874-8bhkd Total loading time: 0 Render date: 2024-11-19T08:29:29.583Z Has data issue: false hasContentIssue false
  • English
  • Français

Increasing burden of Escherichia coli, Klebsiella pneumoniae, and Enterococcus faecium in hospital-acquired bloodstream infections (2000–2014): A national dynamic cohort study

Published online by Cambridge University Press:  23 April 2019

Koen Blot Open the ORCID record for Koen Blot [Opens in a new window] ,
Naïma Hammami ,
Stijn Blot ,
Dirk Vogelaers  and
Marie-Laurence Lambert
Koen Blot*
Affiliation:
Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium
Naïma Hammami
Affiliation:
Healthcare-Associated Infections and Antimicrobial Resistance, Public Health and Surveillance Department, Scientific Institute of Public Health, Brussels, Belgium
Stijn Blot
Affiliation:
Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium Burns, Trauma and Critical Care Research Centre, University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia
Dirk Vogelaers
Affiliation:
Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium General Internal Medicine, Ghent University Hospital, Ghent, Belgium
Marie-Laurence Lambert
Affiliation:
Healthcare-Associated Infections and Antimicrobial Resistance, Public Health and Surveillance Department, Scientific Institute of Public Health, Brussels, Belgium
*
Author for correspondence: Koen Blot, Email: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

The epidemiology of hospital-acquired bloodstream infections (HABSIs) based on the Belgian national surveillance program was analyzed (2000–2014). Our mixed-effects regression analysis identified increased rates of Escherichia coli, Klebsiella pneumoniae, and Enterococcus faecium. HABSI incidence and resistance patterns should be further monitored because of their impact on proper empiric antibiotic therapy.

Type
Concise Communication
Information
Infection Control & Hospital Epidemiology , Volume 40 , Issue 6 , June 2019 , pp. 705 - 709
Copyright
© 2019 by The Society for Healthcare Epidemiology of America. All rights reserved. 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Blot, SI, Depuydt, P, Annemans, L, et al. Clinical and economic outcomes in critically ill patients with nosocomial catheter-related bloodstream infections. Clin Infect Dis 2005;41:1591–1598.CrossRefGoogle ScholarPubMed
Vrijens, F, Hulstaert, F, Van de Sande, S, Devriese, S, Morales, I, Parmentier, Y. Hospital-acquired, laboratory-confirmed bloodstream infections: linking national surveillance data to clinical and financial hospital data to estimate increased length of stay and healthcare costs. J Hosp Infect 2010;75:158–162.CrossRefGoogle ScholarPubMed
Pien, BC, Sundaram, P, Raoof, N, et al. The clinical and prognostic importance of positive blood cultures in adults. Am J Med 2010;123:819–828.CrossRefGoogle ScholarPubMed
European Centre for Disease Prevention and Control. Antimicrobial resistance surveillance in Europe 2015. Annual Report of the European Antimicrobial Resistance Surveillance Network (EARS-Net). Stockholm: ECDC; 2017.Google Scholar
WIV-ISP. Surveillance nationale des septicémies dans les hôpitaux belges 2017. Sciensano website. http://www.nsih.be/surv_sep/beschrijving_fr.asp. Published 2017. Accessed March 8, 2019.Google Scholar
Garner, JS, Jarvis, WR, Emori, TG, Horan, TC, Hughes, JM. CDC definitions for nosocomial infections, 1988. Am J Infect Control 1988;16:128–140.CrossRefGoogle ScholarPubMed
Central line-associated bloodstream infection (CLABSI) event protocol. Center for Disease Control and Prevention website. http://www.cdc.gov/nhsn/PDFs/pscManual/4PSC_CLABScurrent.pdf. Updated January 2019. Accessed March 8, 2019.Google Scholar
Blot, K, Bergs, J, Vogelaers, D, Blot, S, Vandijck, D. Prevention of central line-associated bloodstream infections through quality improvement interventions: a systematic review and meta-analysis. Clin Infect Dis 2014;59:96–105.CrossRefGoogle ScholarPubMed
Fontela, PS, Quach, C, Buckeridge, D, Pai, M, Platt, RW. Surveillance length and validity of benchmarks for central line-associated bloodstream infection incidence rates in intensive care units. PLoS One 2012;7:e36582–6. doi: 10.1371/journal.pone.0036582.CrossRefGoogle ScholarPubMed
Blot, SI, Vandewoude, KH, Colardyn, FA. Evaluation of outcome in critically ill patients with nosocomial enterobacter bacteremia: results of a matched cohort study. Chest 2003;123:1208–13.CrossRefGoogle ScholarPubMed
Blot, SI, Vandewoude, KH, Colardyn, FA. Clinical impact of nosocomial Klebsiella bacteremia in critically ill patients. Eur J Clin Microbiol Infect Dis 2002;21:471–473.Google ScholarPubMed
Blot, S, Vandewoude, K, Hoste, E, et al. Absence of excess mortality in critically ill patients with nosocomial Escherichia coli bacteremia. Infect Control Hosp Epidemiol 2003;24:912–915.CrossRefGoogle ScholarPubMed
Holmbom, M, Giske, CG, Fredrikson, M, et al. 14-Year survey in a Swedish county reveals a pronounced increase in bloodstream infections (BSI). Comorbidity—an independent risk factor for both BSI and mortality. PLoS One 2016;11:e0166527. doi: 10.1371/journal.pone.0166527.CrossRefGoogle Scholar
Wilson, J, Elgohari, S, Livermore, DM, et al. Trends among pathogens reported as causing bacteraemia in England, 2004–2008. Clin Microbiol Infect 2011;17:451–458.CrossRefGoogle Scholar
Buetti, N, Marschall, J, Atkinson, A, Kronenberg, A, Swiss Centre for Antibiotic Resistance (ANRESIS). National bloodstream infection surveillance in Switzerland 2008–2014: different patterns and trends for university and community hospitals. Infect Control Hosp Epidemiol 2016;37:1060–1067.CrossRefGoogle ScholarPubMed
Søgaard, M, Nørgaard, M, Dethlefsen, C, Schønheyder, HC. Temporal changes in the incidence and 30-day mortality associated with bacteremia in hospitalized patients from 1992 through 2006: a population-based cohort study. Clin Infect Dis 2011;52:61–69.CrossRefGoogle ScholarPubMed
McGregor, JC, Rich, SE, Harris, AD, et al. A systematic review of the methods used to assess the association between appropriate antibiotic therapy and mortality in bacteremic patients. Clin Infect Dis 2007;45:329–337.CrossRefGoogle ScholarPubMed
Supplementary material: File

Blot et al. supplementary material

Blot et al. supplementary material 1

Download Blot et al. supplementary material(File)
File 510.5 KB