Hostname: page-component-586b7cd67f-t7fkt Total loading time: 0 Render date: 2024-11-24T23:39:40.885Z Has data issue: false hasContentIssue false
  • English
  • Français

The impact of formulary restriction on the relative consumption of carbapenems in intensive care units at an academic medical center

Published online by Cambridge University Press:  24 June 2019

Jacob W. Pierce Open the ORCID record for Jacob W. Pierce [Opens in a new window] ,
Andrew Kirk ,
Kimberly B. Lee ,
John D. Markley ,
Amy Pakyz ,
Gonzalo Bearman ,
Michelle E. Doll  and
Michael P. Stevens
Jacob W. Pierce
Affiliation:
Department of Internal Medicine, Virginia Commonwealth University Health System, Richmond, Virginia
Andrew Kirk
Affiliation:
Virginia Commonwealth University School of Medicine, Richmond, Virginia
Kimberly B. Lee
Affiliation:
Virginia Commonwealth University Health System, Richmond, Virginia
John D. Markley
Affiliation:
Department of Infectious Diseases, Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, Virginia
Amy Pakyz
Affiliation:
Virginia Commonwealth University School of Pharmacy, Richmond, Virginia
Gonzalo Bearman
Affiliation:
Virginia Commonwealth University Health System, Richmond, Virginia Division of Infectious Diseases, Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia
Michelle E. Doll
Affiliation:
Virginia Commonwealth University Health System, Richmond, Virginia Division of Infectious Diseases, Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia
Michael P. Stevens*
Affiliation:
Virginia Commonwealth University Health System, Richmond, Virginia Division of Infectious Diseases, Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia
*
Author for correspondence: Michael P. Stevens, E-mail: [email protected].
Get access Rights & Permissions [Opens in a new window]

Abstract

Antipseudomonal carbapenems are an important target for antimicrobial stewardship programs. We evaluated the impact of formulary restriction and preauthorization on relative carbapenem use for medical and surgical intensive care units at a large, urban academic medical center using interrupted time-series analysis.

Type
Concise Communication
Information
Infection Control & Hospital Epidemiology , Volume 40 , Issue 9 , September 2019 , pp. 1056 - 1058
Copyright
© 2019 by The Society for Healthcare Epidemiology of America. All rights reserved. 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

CDC. Antibiotic resistance threats in the United States, 2013. Current 2013;00. doi: CS239559-B.Google Scholar
Livorsi, DJ, Chorazy, ML, Schweizer, ML, et al. A systematic review of the epidemiology of carbapenem-resistant Enterobacteriaceae in the United States. Antimicrob Resist Infect Control 2018;7:1–9.CrossRefGoogle ScholarPubMed
Baggs, J, Fridkin, SK, Pollack, LA, Srinivasan, A, Jernigan, JA. Estimating national trends in inpatient antibiotic use among US hospitals from 2006 to 2012. JAMA Intern Med 2016;176:1639–1648.Google ScholarPubMed
Klein, EY, Van Boeckel, TP, Martinez, EM, et al. Global increase and geographic convergence in antibiotic consumption between 2000 and 2015. Proc Natl Acad Sci 2018. doi: 10.1073/pnas.1717295115.CrossRefGoogle Scholar
Hirayama, S, Yasui, K, Murakami, H, et al. A new carbapenem drug dosage metric for carbapenem usage and correlation with carbapenem resistance of Pseudomonas aeruginosa. J Infect Chemother 2018;24:949–953.CrossRefGoogle ScholarPubMed
Ogutlu, A, Guclu, E, Karabay, O, Utku, AC, Tuna, N, Yahyaoglu, M. Effects of carbapenem consumption on the prevalence of acinetobacter infection in intensive care unit patients. Ann Clin Microbiol Antimicrob 2014;13:1–6.CrossRefGoogle ScholarPubMed
Remschmidt, C, Schneider, S, Meyer, E, Schroeren-Boersch, B, Gastmeier, P, Schwab, F. Surveillance of antibiotic use and resistance in intensive care units (SARI)—a 15-year cohort study. Dtsch Arztebl Int 2017;114:858–865.Google Scholar
Luyt, C-E, Bréchot, N, Trouillet, J-L, Chastre, J. Antibiotic stewardship in the intensive care unit. Crit Care 2014;18:480.CrossRefGoogle ScholarPubMed
Dellit, TH, Owens, RC, Mcgowan, JE, et al. Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America guidelines for developing an institutional program to enhance antimicrobial stewardship. 2007;44:159–177.Google Scholar
Markley, JD, Pakyz, AL, Sabo, RT, Bearman, G, Hohmann, SF, Stevens, MP. Performance of a novel antipseudomonal antibiotic consumption metric among academic medical centers in the United States. 2015;39(2).CrossRefGoogle Scholar