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Guidelines for the Management of Intravascular Catheter-Related Infections

Published online by Cambridge University Press:  02 January 2015

Leonard A. Mermel
Affiliation:
Division of Infectious Diseases, Brown University School of Medicine, Rhode Island Hospital, Providence, Rhode Island
Barry M. Farr
Affiliation:
University of Virginia Health System, Charlottesville, Virginia
Robert J. Sherertz
Affiliation:
Section of Infectious Diseases, Wake Forest University School of Medicine, Winston-Salem, North Carolina
Issam I. Raad
Affiliation:
Department of Internal Medicine Specialties, the University of Texas M.D. Anderson Cancer Center, Houston, Texas
Naomi O'Grady
Affiliation:
Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland
JoAnn S. Harris
Affiliation:
Section of Pediatric Infectious Diseases, Boston University School of Medicine, Boston, Massachusetts
Donald E. Craven*
Affiliation:
Section of Infectious Diseases, Boston University Schools of Medicine and Public Health, Boston Medical Center, Boston, Massachusetts Lahey Clinic Medical Center, Burlington, Massachusetts
*
Lahey Clinic Medical Center, Burlington, MA 01806 ([email protected])

Extract

These guidelines from the Infectious Diseases Society of America (IDSA), the American College of Critical Care Medicine (for the Society of Critical Care Medicine), and the Society for Healthcare Epidemiology of America contain recommendations for the management of adults and children with, and diagnosis of infections related to, peripheral and nontunneled central venous catheters (CVCs), pulmonary artery catheters, tunneled central catheters, and implantable devices. The guidelines, written for clinicians, contain IDSA evidence-based recommendations for assessment of the quality and strength of the data. Recommendations are presented according to the type of catheter, the infecting organism, and the associated complications.

Intravascular catheter-related infections are a major cause of morbidity and mortality in the United States. Coagulase-negative staphylococci, Staphylococcus aureus, aerobic gram-negative bacilli, and Candida albicans most commonly cause catheter-related bloodstream infection. Management of catheter-related infection varies according to the type of catheter involved. After appropriate cultures of blood and catheter samples are done, empirical iv antimicrobial therapy should be initiated on the basis of clinical clues, the severity of the patient's acute illness, underlying disease, and the potential pathogen (s) involved. In most cases of nontunneled CVC-related bacteremia and fungemia, the CVC should be removed.

Type
Special Report
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2001

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References

1. Gross, PA, Barrett, TL, Dellinger, P, et al. Purpose of quality standards for infectious diseases. Infectious Diseases Society of America. Clin Infect Dis 1994;18:421.Google Scholar
2. Maki, DG, Mermel, LA. Infections due to infusion therapy. In: Bennett, JV, Brachman, PS, eds. Hospital Infections. Philadelphia: Lippincott-Raven, 1998:689724.Google Scholar
3. Pearson, ML, Hospital Infection Control Practices Advisory Committee (HICPAC). Guideline for prevention of intravascular-device-related infections. Infect Control Hosp Epidemiol 1996;17:438–73Google Scholar
4. Jarvis, WR, Edwards, JE, Culver, DH, et al. Nosocomial infection rates in adult and pediatric intensive care units in the United States. Am J Med 1991;91(Suppl 3B):185S–91S.CrossRefGoogle ScholarPubMed
5. Mayhall, CG. Diagnosis and management of infections of implantable devices used for prolonged venous access. Curr Clin Top Infect Dis 1992;12:83110.Google Scholar
6. Sherertz, RJ, Heard, SO, Raad, II. Diagnosis of triple-lumen catheter infection: comparison of roll plate, sonification, and flushing methodologies. J Clin Microbiol 1997;35:641–6.CrossRefGoogle Scholar
7. American Academy of Pediatrics. Red Book 2000: Report of a Committee on Infectious Diseases. 25th ed. Elk Grove Village, IL: American Academy of Pediatrics, 2000.Google Scholar
8. Nelson, JD. 2000 Pocket Book of Pediatric Antimicrobial Therapy. 14th ed. Baltimore: Lippincott, Williams & Wilkins, 2000.Google Scholar
9. Pittet, D, Tamara, D, Wenzel, RP. Nosocomial bloodstream infection in critically ill patients: excess length of stay, extra costs, and attributable mortality. JAMA 1994;271:1598–601.Google Scholar
10. Byers, K, Adal, K, Anglim, A, et al. Case fatality rate for catheter-related bloodstream infections (CRSBI): a meta-analysis [abstract 43]. In: Proceedings of the 5th Annual Meeting of the Society for Hospital Epidemiology of America, 1995.Google Scholar
11. Kiehn, TE, Armstrong, D. Changes in the spectrum of organisms causing bacteremia and fungemia in immunocompromised patients due to venous access devices. Eur J Clin Microbiol Infect Dis 1990;9:869–72.CrossRefGoogle ScholarPubMed
12. Siegman-Igra, Y, Anglim, AM, Shapiro, DE, et al. Diagnosis of vascular catheter-related bloodstream infection: a meta-analysis. J Clin Microbial 1997;35:928–36.Google Scholar
13. Brun-Buisson, C, Abrouk, F, Legrand, P, et al. Diagnosis of central venous catheter-related sepsis: critical level of quantitative tip cultures. Arch Intern Med 1987;147:873–7.Google Scholar
14. Maki, DG, Weise, CE, Sarafin, HW. A semiquantitative culture method for identifying intravenous catheter-related infections. N Engl J Med 1977;296:1305–9.CrossRefGoogle Scholar
15. Mermel, LA, Maki, DG. Infectious complications of Swan-Ganz pulmonary artery catheters and peripheral arterial catheters. In: Seifert, H, Jansen, B, Farr, BM, eds. Catheter-Related Infections. New York: Marce Dekker, 1997:259305.Google ScholarPubMed
16. Kite, P, Dobbins, BM, Wilcox, MH, et al. Rapid diagnosis of central-venous-catheter-related bloodstream infection without catheter removal. Lancet 1999;354:1504–7.Google Scholar
17. DesJardin, J. Clinical utility of blood cultures drawn from indwelling central venous catheters in hospitalized patients with cancer. Ann Intern Med 1999;131:641–7.CrossRefGoogle ScholarPubMed
18. Dunne, WM Jr Nolte, FS, Wilson, ML. Blood cultures III. In: Hindler, JA, ed. Cumitech IB. Washington, DC: American Society for Microbiology, 1997:121.Google Scholar
19. Fan, ST, Teoh-Chan, CH, Lau, KF. Evaluation of central venous catheter sepsis by differential quantitative blood culture. Eur J Clin Microbiol Infect Dis 1989;8:142–4.CrossRefGoogle ScholarPubMed
20. Blot, F, Schmidt, E, Nitenberg, G, et al. Earlier positivity of central venous versus peripheral blood cultures is highly predictive of catheter related sepsis. J Clin Microbiol 1998;36:105–9.CrossRefGoogle ScholarPubMed
21. Blot, F, Nitenberg, G, Chachaty, E, et al. Diagnosis of catheter-related bacteremia: a prospective comparison of the time to positivity of hub-blood versus peripheral-blood cultures. Lancet 1999;354:1071–7.CrossRefGoogle ScholarPubMed
22. Rello, J, Coll, P, Prats, G. Evaluation of culture techniques for diagnosis of catheter-related sepsis in critically ill patients [letter]. Eur J Clin Microbiol Infect Dis 1992;11:1192–3.Google Scholar
23. Kristinsson, KG. Diagnosis of catheter-related infections. In: Seifert, H, Jansen, B, Farr, BM, eds. Catheter-Related Infections. New York: Marcel Dekker, 1997:3157.Google Scholar
24. Pettigrew, RA, Lang, SDR, Haydock, DA, et al. Catheter-related sepsis in patients on intravenous nutrition: a prospective study of quantitative catheter cultures and guidewire changes for suspected sepsis. Br J Surg 1985;72:52–5.CrossRefGoogle ScholarPubMed
25. Armstrong, CW, Mayhall, CG, Miller, KB, et al. Prospective study of catheter replacement and other risk factors for infection of hyperalimentation catheters. J Infect Dis 1986;154:808–16.Google Scholar
26. Raad, I, Davis, S, Khan, A, et al. Impact of central venous catheter removal on the recurrence of catheter-related coagulase-negative staphylococcal bacteremia. Infect Control Hosp Epidemiol 1992;13:215–21.Google Scholar
27. Li, JS, Sexton, DJ, Mick, N, et al. Proposed modifications to the Duke Criteria for the diagnosis of infective endocarditis. Clin Infect Dis 2000;30:633–8.CrossRefGoogle Scholar
28. Hartstein, AI, Mulligan, ME, Morthland, VH. Recurrent Staphylococcus aureus bacteremia. J Clin Microbiol 1992;30:670–4.CrossRefGoogle ScholarPubMed
29. Rosen, AB, Fowler, VG, Corey, GR, et al. Cost-effectiveness of transesophageal echocardiography to determine the duration of therapy for intravascular catheter-associated Staphylococcus aureus bacteremia. Ann Intern Med 1999;130:810–20.Google Scholar
30. Fowler, VG, Li, J, Corey, GR, et al. Role of echocardiography in evaluation of patients with Staphylococcus aureus bacteremia: experience in 103 patients. J Am Coll Cardiol 1997;30:1072–3.CrossRefGoogle ScholarPubMed
31. Raad, I. Optimal duration of therapy for catheter-related Staphylococcus aureus bacteremia: a study of 55 cases and review. Clin Infect Dis 1992;14:7582.Google Scholar
32. Peacock, SJ, Eddleston, M, Emptage, A, et al. Positive intravenous line tip cultures as predictors of bacteremia. J Hosp Infect 1998;40:35–8.Google Scholar
33. Arnow, PM, Quimosing, EM, Beach, M. Consequences of intravascular catheter sepsis. Clin Infect Dis 1993;16:778–84.Google Scholar
34. Raad, I. Intravascular-catheter-related infections. Lancet 1998;351:893–8.CrossRefGoogle ScholarPubMed
35. Velez, LA, Mermel, LA, Zilz, MA, et al. Epidemiologic and microbiologic features of nosocomial bloodstream infection (NBSI) implicating a vascular catheter source: a case-control study of 85 vascular catheter-related and 101 secondary NBSIs [abstract]. Infect Control Hosp Epidemiol 1992;13:562.Google Scholar
36. Dugdale, DC, Ramsey, P. Staphylococcus aureus bacteremia in patients with Hickman catheters. Am J Med 1990;89:137–41.Google Scholar
37. Gaillard, JL, Merlino, R, Pajot, N, et al. Conventional and nonconventional modes of vancomycin administration to decontaminate the internal surface of catheters colonized with coagulase-negative staphylococci. JPEN J Parenter Enteral Nutr 1990;14:593–7.Google Scholar
38. Rao, JS, O'Meara, A, Harvey, T, et al. A new approach to the management of Broviac catheter infection. J Hosp Infect 1992;22:109–16.Google Scholar
39. Messing, B, Man, F, Colimon, R, et al. Antibiotic lock technique is an effective treatment of bacterial catheter related sepsis during parenteral nutrition. Clin Nutr 1990;9:220–7.CrossRefGoogle ScholarPubMed
40. Capdevila, JA, Segarra, A, Planes, A, et al. Long term follow-up of patients with catheter related sepsis (CRS) treated without catheter removal [abstract J3]. In: Program and Abstracts of the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy (San Francisco). Washington, DC: American Society for Microbiology, 1995.Google Scholar
41. Capdevila, JA, Segarra, A, Planes, AM, et al. Successful treatment of haemodialysis catheter-related sepsis without catheter removal. Nephrol Dial Transplant 1993;8:231–4.Google ScholarPubMed
42. Capdevila, JA, Barbera, J, Gavalda, J, et al. Diagnosis and conservative management (CM) of infection related to long term venous catheterization (CI) in AIDS patients [abstract J55]. In: Program and Abstracts of the 34th Interscience Conference on Antimicrobial Agents and Chemotherapy (Orlando, FL). Washington, DC: American Society for Microbiology, 1994:69.Google Scholar
43. Krzywda, EA, Andris, DA, Edmiston, CE, et al. Treatment of Hickman catheter sepsis using antibiotic lock technique. Infect Control Hosp Epidemiol 1995;16:596–8.Google Scholar
44. Andris, DA, Krzywda, EA, Edmiston, CE, et al. Elimination of intraluminal colonization by antibiotic lock in silicone vascular catheters. Nutrition 1998;14:427–32.Google Scholar
45. Domingo, P, Fontanet, A, Sanchez, F, et al. Morbidity associated with long-term use of totally implantable ports in patients with AIDS. Clin Infect Dis 1999;29:346–51.Google Scholar
46. Gibson, SP, Mosquera, D. Five years' experience with the Quinton Permcath for vascular access. Nephrol Dial Transplant 1991;6:269–74.CrossRefGoogle ScholarPubMed
47. Rello, J, Gatell, JM, Almirall, J, et al. Evaluation of culture techniques for identification of catheter-related infection in hemodialysis patients. Eur J Clin Microbiol Infect Dis 1989;8:620–2.Google Scholar
48. Saltissi, D, Macfarlane, DJ. Successful treatment of Pseudomonas paucimobilis haemodialysis catheter-related sepsis without catheter removal. Postgrad Med 1994;70:47–8.CrossRefGoogle ScholarPubMed
49. Carlisle, EJ, Blake, P, McCarthy, F, et al. Septicemia in long-term jugular hemodialysis catheters: eradicating infection by changing the catheter over a guide wire. Int J Artif Organs 1991;14:150–3.Google Scholar
50. Kairraitis, LK, Gottlieb, T. Outcome and complications of temporary haemodialysis catheters. Nephrol Dial Transplant 1999;14:1710–4.CrossRefGoogle Scholar
51. Boelaert, JR, Van Landyt, HW, Godard, CA, et al. Nasal mupirocin ointment decreases the incidence of Staphylococcus aureus bacteremia in hemodialysis patients. Nephrol Dial Transplant 1993;8:235–9.Google Scholar
52. Holton, DL, Nicolle, LE, Diley, D, et al. Efficacy of mupirocin nasal ointment in eradicating Staphylococcus aureus nasal carriage in chronic hemodialysis patients. J Hosp Infect 1991;17:133–7.CrossRefGoogle Scholar
53. Watanakunakorn, C, Brandt, J, Durkin, P, et al. The efficacy of mupirocin ointment and chlorhexidine body scrubs in the eradication of nasal carriage of Staphylococcus aureus among patients undergoing long-term hemodialysis. Am J Infect Control 1992;20:138–41.Google Scholar
54. Reagan, DR, Doebbeling, BD, Pfaller, MA, et al. Elimination of coincident Staphylococcus aureus nasal and hand carriage with intranasal application of mupirocin calcium ointment. Ann Intern Med 1991;114:101–6.Google Scholar
55. Cooper, GL, Hopkins, CC. Rapid diagnosis of intravascular catheter-associated infection by direct gram staining of catheter segments. N Engl J Med 1985;312:1142–7.CrossRefGoogle ScholarPubMed
56. Raad, I, Costerton, W, Sabharwal, U, et al. Ultrastructural analysis of indwelling vascular catheters: a quantitative relationship between luminal colonization and duration of placement. J Infect Dis 1993;168:400–7.Google Scholar
57. Schmitt, SK, Knapp, C, Hall, GS, Longworth, DL, McMahon, JT, Washington, JA. Impact of chlorhexidine-silver sulfadiazine-impregnated central venous catheters on in vitro quantitation of catheter-associated bacteria. J Clin Microbiol 1996;34:508–11.CrossRefGoogle ScholarPubMed
58. Maki, DG, Stolz, SM, Wheeler, S, et al. Prevention of central venous catheter-related bloodstream infection by use of an antiseptic-impregnated catheter: a randomized, controlled trial. Ann Intern Med 1997;127:257–66.Google Scholar
59. Cleri, DJ, Corrado, ML, Seligman, SJ. Quantitative culture of intravenous catheters and other intravascular inserts. J Infect Dis 1980;141:781–6.Google Scholar
60. Sherertz, RJ, Raad, II, Belani, A, et al. Three-year experience with sonicated vascular catheter cultures in a clinical microbiology laboratory. J Clin Microbiol 1990;28:7682.CrossRefGoogle Scholar
61. Irwig, L, Tosteson, ANA, Gatsonis, C, et al. Guidelines for meta-analyses evaluating diagnostic tests. Ann Intern Med 1994;120:667–76.Google Scholar
62. Capdevilla, JA, Planes, AM, Polomar, M, et al. Value of differential quantitative blood cultures in the diagnosis of catheter-related sepsis. Eur J Clin Microbiol Infect Dis 1992;11:403–7.Google Scholar
63. La Quaglia, MP, Caldwell, C, Lucas, A, et al. A prospective randomized double-blind trial of bolus urokinase in the treatment of established Hickman catheter sepsis in children. J Pediatr Surg 1994;29:742–5.Google Scholar
64. Atkinson, JB, Chamberlin, K, Boody, BA. A prospective randomized trial of urokinase as an adjuvant in the treatment of proven Hickman catheter-sepsis. J Pediatr Surg 1998;33:714–6.Google Scholar
65. Raad, II, Sabbagh, MF. Optimal duration of therapy for catheter-related Staphylococcus aureus bacteremia: a study of 55 cases and review. Clin Infect Dis 1992;14:7582.Google Scholar
66. Garrison, PK, Freedman, LR. Experimental endocarditis I. Staphylococcal endocarditis in rabbits resulting from placement of a polyethylene catheter in the right side of the heart. Yale J Biol Med 1970;42:394410.Google Scholar
67. Widmer, AF, Nettleman, M, Flint, K, et al. The clinical impact of culturing central venous catheters. Arch Intern Med 1992;152:1299–302.Google Scholar
68. Herwaldt, LA, Geiss, M, Kao, C, et al. The positive predictive value of isolating coagulase-negative staphylococci from blood cultures. Clin Infect Dis 1996;22:1420.CrossRefGoogle ScholarPubMed
69. Chambers, H, Miller, R, Newman, M. Right-sided Staphylococcus aureus endocarditis in intravenous drug abusers: two-week combination therapy. Ann Intern Med 1988;109:619–24.Google Scholar
70. Archer, GL. Staphylococcus epidermidis and other coagulase negative staphylococci. In: Mandell, GL, Bennett, JE, Dolin, R, eds. Principles and Practice of Infectious Diseases. 5th ed. New York: Churchill Livingstone, 2000:2092–100.Google Scholar
71. Massanari, RM, Donta, ST. The efficacy of rifampin as adjunctive therapy in selected cases of staphylococcal endocarditis. Chest 1978;73:371–5.Google Scholar
72. Vasquez, GJ, Archer, GL. Antibiotic therapy of experimental Staphylococcus epidermidis endocarditis. Antimicrob Agents Chemother 1980;17:280–5.CrossRefGoogle Scholar
73. Karchmer, AW, Archer, GL, Dismukes, WE. Staphylococcus epidermidis prosthetic valve endocarditis: microbiological and clinical observations as guide to therapy. Ann Intern Med 1983;98:447–55.Google Scholar
74. Kobasa, WD, Kaye, KL, Shapiro, T, et al. Therapy for experimental endocarditis due to Staphylococcus epidermidis . Rev Infect Dis 1983;5:S533–7.Google Scholar
75. Herrmann, M, Peters, G. Catheter-associated infections caused by coagulase negative staphylococci: clinical and biological aspects. In: Seifert, H, Jansen, B, Farr, BM, eds. Catheter-Related Infections. New York: Marcel Dekker, 1997:79109.Google Scholar
76. Benoit, JL, Carandang, G, Sitrin, M, et al. Intraluminal antibiotic treatment of central venous catheter infections in patients receiving parenteral nutrition at home. Clin Infect Dis 1995;21:1286–8.Google Scholar
77. Malanoski, G, Samore, M, Pefanis, A, et al. Staphylococcus aureus bacteremia: minimal effective therapy and unusual infectious complications associated with arterial sheath catheters. Arch Intern Med 1995;155:1161–6.CrossRefGoogle ScholarPubMed
78. Fowler, VG, Sanders, LL, Sexton, DJ, et al. Outcome of Staphylococcus aureus bacteremia according to compliance with recommendations of infectious diseases specialists: experience with 244 patients. Clin Infect Dis 1998;27:478–86.Google Scholar
79. Nguyen, MH, Peacock, JE Jr Tanner, DC, et al. Therapeutic approaches in patients with candidemia: evaluation in a multicenter prospective observational study. Arch Intern Med 1995;155:2429–35.CrossRefGoogle Scholar
80. Hospital Infection Control Practices and Advisory Committee (HICPAC), Centers for Disease Control and Prevention. Recommendations for preventing the spread of vancomycin resistance. HICPAC. Infect Control Hosp Epidemiol 1995;16:105–13.Google Scholar
81. Small, P, Chambers, HF. Vancomycin for Staphylococcus aureus endocarditis in intravenous drug abusers. Antimicrob Agents Chemother 1990;34:1227–31.CrossRefGoogle Scholar
82. Levine, DP, Fromm, B, Reddy, B. Slow response to vancomycin or vancomycin plus rifampin therapy among patients with methicillin-resistant Staphylococcus aureus . Ann Intern Med 1991;115:674–80.CrossRefGoogle ScholarPubMed
83. Libman, H, Arbeit, RD. Complications associated with Staphylococcus aureus bacteremia. Arch Intern Med 1984;144:541–5.Google Scholar
84. Benezra, D, Kiehn, TE, Gold, JWM, et al. Prospective study of infections in indwelling central venous catheters using quantitative blood cultures. Am J Med 1988;85:495–8.Google Scholar
85. Williams, N, Carlson, GL, Scott, NA, et al. Incidence and management of catheter-related sepsis in patients receiving home parenteral nutrition. Br J Surg 1994;81:392–4.CrossRefGoogle ScholarPubMed
86. Rubin, LG, Shih, S, Shende, A, et al. Cure of implantable venous port-associated bloodstream infections in pediatric hematology-oncology patients without catheter removal. Clin Infect Dis 1999;29:102–5.CrossRefGoogle ScholarPubMed
87. Elting, LS, Bodey, GP. Septicemia due to Xanthomonas species and non-aeruginosa Pseudomonas species: increasing incidence of catheter-related infections. Medicine (Baltimore) 1990;69:296306.Google Scholar
88. Seifert, H, Strate, A, Pulverer, G. Nosocomial bacteremia due to Acinetobacter baumannii: clinical features, epidemiology, and predictors of mortality. Medicine 1995;74:340–9.Google Scholar
89. Widmer, AF, Wiestner, A, Frei, R, et al. Killing of non-growing and adherent Escherichia coli determines drug efficacy in device-related infections. Antimicrob Agents Chemother 1991;35:741–6.Google Scholar
90. Ishida, H, Ishida, Y, Kurosaka, Y, et al. In vitro and in vivo activities of levofloxacin against biofilm-producing Pseudomonas aeruginosa . Antimicrob Agents Chemother 1998;42:1641–5.CrossRefGoogle ScholarPubMed
91. Ashby, MJ, Neale, SJ, Knott, SJ, et al. Effect of antibiotics on non-growing planktonic cells and biofilms of Escherichia coli . J Antimicrob Chemother 1994;33:443–52.CrossRefGoogle ScholarPubMed
92. Voss, A. Miscellaneous organisms. In: Seifert, H, Jansen, B, Farr, BM, eds. Catheter-Related Infections. New York: Marcel Dekker, 1997:157–82.Google Scholar
93. Seifert, H. Catheter-related infections due to gram-negative bacilli. In: Seifert, H, Jansen, B, Farr, BM, eds. Catheter-Related Infections. New York: Marcel Dekker, 1997:111–38.Google Scholar
94. Gill, MV, Klein, NC, Cuhna, BA. Unusual organisms causing intravenous line infections in compromised hosts. I. Bacterial and algal infections. Infect Dis Clin Pract 1996;5:244–55.Google Scholar
95. Rex, JH, Bennett, JE, Sugar, AM, et al. A randomized trial comparing fluconazole with amphotericin B for the treatment of candidemia in patients without neutropenia. N Engl J Med 1994;331:1325–30.Google Scholar
96. Rex, JH, Walsh, TJ, Sobel, JD, et al. Practice guidelines for the treatment of candidiasis. Clin Infect Dis 2000;30:662–78.CrossRefGoogle ScholarPubMed
97. Rex, JH, Bennett, JE, Sugar, AM, et al. Intravascular catheter exchange and duration of candidemia. Clin Infect Dis 1995;21:994–6.Google Scholar
98. Pittet, D, Hulliger, S, Auckenthaler, R. Intravascular device-related infections in critically ill patients. J Chemother 1995;7:5566.Google ScholarPubMed
99. Edwards, JE, Bodey, GP, Bowden, RA, et al. International conference for the development of a consensus on the management and prevention of severe candidal infections. Clin Infect Dis 1997;25:4359.Google Scholar
100. Johnson, DC, Johnson, FL, Goldman, S. Preliminary results treating persistent central venous catheter infections with the antibiotic lock technique in pediatric patients. Pediatr Infect Dis J 1994;13:930–1.Google Scholar
101. Arnow, P, Kushner, R. Malassezia furfur catheter infection cured with antibiotic lock therapy [letter]. Am J Med 1991;90:128–30.Google Scholar
102. Marcon, MJ, Powell, DA. Human infections due to Malassezia spp. Clin Microbiol Rev 1992;5:101–19.Google Scholar
103. Barber, GR, Brown, AE, Kiehn, TE, et al. Catheter-related Malassezia furfur fungemia in immunocompromised patients. Am J Med 1993;95:365–70.Google Scholar
104. Verghese, A, Widrich, WC, Arbeit, RD. Central venous septic thrombophlebitis: the role of medical therapy. Medicine (Baltimore) 1985;64:394400.CrossRefGoogle ScholarPubMed
105. Strinden, WD, Helgerson, RB, Maki, DG. Candida septic thrombosis of the great central veins associated with central catheters. Ann Surg 1985;202:653–8.Google Scholar
106. Topiel, MS, Bryan, RT, Kessler, CM, et al. Case report: treatment of Silastic catheter-induced central vein septic thrombophlebitis. Am J Med Sci 1986;291:425–8.Google Scholar
107. Kaufman, J, Demas, C, Stark, K, et al. Catheter-related septic central venous thrombosis: current therapeutic options. West J Med 1986;145:200–3.Google Scholar
108. Fry, DE, Fry, RV, Borzotta, AP. Nosocomial blood-borne infection secondary to intravascular devices. Am J Surg 1994;167:268–72.CrossRefGoogle ScholarPubMed
109. Andes, DR, Urban, AW, Archer, CW, et al. Septic thrombosis of the maxillary and subclavian veins caused by a peripherally inserted central venous catheter. Am J Med 1998;105:446–50.Google Scholar
110. Maki, DG, McCormick, RD, Uman, SJ, et al. Septic endarteritis due to intra-arterial catheters for cancer chemotherapy. I. Evaluation of an outbreak. II. Risk factors, clinical features and management. III. Guidelines for prevention. Cancer 1979;44:1228–40.3.0.CO;2-1>CrossRefGoogle ScholarPubMed
111. Falk, PS, Scuderi, PE, Sherertz, RJ, et al. Infected radial artery pseudoaneurysms occurring after percutaneous cannulation. Chest 1992;101:490–5.Google Scholar
112. Torres-Rojas, JR, Stratton, CW, Sanders, CV, et al. Candidal suppurative peripheral thrombophlebitis. Ann Intern Med 1982;96:431–5.CrossRefGoogle ScholarPubMed
113. Walsh, TJ, Bustamente, CI, Vlahov, D, et al. Candidal suppurative peripheral thrombophlebitis: recognition, prevention, and management. Infect Control 1986;7:1622.CrossRefGoogle ScholarPubMed
114. Garrison, RN, Richardson, JD, Fry, DE. Catheter-associated septic thrombophlebitis. South Med J 1982;75:917–9.Google Scholar
115. Wilson, WR, Karchmer, AW, Dajani, AS, et al. Antibiotic treatment of adults with infective endocarditis due to streptococci, enterococci, staphylococci, and HACEK microorganisms. JAMA 1995;274:1706–13.Google Scholar
116. Fang, G, Keys, TF, Gentry, LO, et al. Prosthetic valve endocarditis resulting from nosocomial bacteremia: a prospective, multicenter study. Ann Intern Med 1993;119:560–7.CrossRefGoogle ScholarPubMed
117. Lamas, CC, Evkyn, SJ. Hospital acquired native valve endocarditis: analysis of 22 cases presenting over 11 years. Heart 1998;79:442–7.Google Scholar
118. Fernandez-Guerrero, ML, Verdejo, C, Azofra, J, et al. Hospital-acquired infectious endocarditis not associated with cardiac surgery: an emerging problem. Clin Infect Dis 1995;20:1623.CrossRefGoogle Scholar
119. Terpenning, MS, Buggy, BP, Kaufman, CA. Hospital-acquired infective endocarditis. Arch Intern Med 1988;148:1601–3.Google Scholar
120. Torres-Tortosa, M, de Cueto, M, Vergara, A, et al. Prospective evaluation of a two-week course of intravenous antibiotics in intravenous drug addicts with infective endocarditis. Eur J Clin Microbiol Infect Dis 1994;13:559–64.CrossRefGoogle ScholarPubMed
121. Ribera, E, Gomez-Jimenez, J, Cortes, E, et al. Effectiveness of cloxacillin with and without gentamicin in short-term therapy for right-sided Staphylococcus aureus endocarditis: a randomized, controlled trial. Ann Intern Med 1996;125:969–73.Google Scholar
122. Hogevik, H, Alestig, K. Fungal endocarditis: a report on seven cases and a brief review. Infection 1996;24:1721.Google Scholar
123. Dahlberg, PJ, Yutuc, WR, Newcomer, KL. Subclavian hemodialysis catheter infections. Am J Kidney Dis 1986;7:421–7.Google Scholar
124. Almirall, J, Gonzalez, J, Rello, J, et al. Infection of hemodialysis catheters: incidence and mechanisms. Am J Nephrol 1989;9:454–9.Google Scholar
125. Cheeseborough, JS, Finch, RG, Burden, RP. A prospective study of the mechanism of infection associated with hemodialysis catheters. J Infect Dis 1986;154:579–89.Google Scholar
126. Keane, WF, Shapiro, FL, Raij, L. Incidence and type of infection occurring in 445 chronic hemodialysis patients. Trans Am Soc Artif Intern Organs 1977;23:41–7.Google Scholar
127. Pezzarossi, HE, Ponce de Leon, S, Calva, JJ, et al. High incidence of subclavian dialysis catheter bacteremias. Infect Control 1986;7:596–9.CrossRefGoogle ScholarPubMed
128. Shaffer, D, Madras, PN, Williams, ME, et al. Use of Dacron cuffed silicone catheters as long-term hemodialysis access. ASAIO J 1992;38:55–8.CrossRefGoogle ScholarPubMed
129. Dobkin, JF, Miller, MH, Steigbigel, NH. Septicemia in patients on chronic hemodialysis. Ann Intern Med 1978;88:2833.Google Scholar
130. Uldall, PR, Merchant, N, Woods, F, et al. Changing subclavian hemodialysis cannulas to reduce infection. Lancet 1981;1:1373.CrossRefGoogle ScholarPubMed
131. Cappello, M, DePauw, L, Bayer, A. Central venous access for hemodialysis using the Hickman catheter. Nephrol Dial Transplant 1989;4:988–92.Google Scholar
132. Schwab, SJ, Buller, GL, McCann, RL, et al. Prospective evaluation of a Dacron cuffed hemodialysis catheter for prolonged use. Am J Kidney Dis 1988;11:166–9.Google Scholar
133. Levin, A, Mason, AJ, Jindal, KK, Fong, IE, Goldstein, MB. Prevention of hemodialysis subclavian vein catheter infections by topical povidone-iodine. Kidney Int 1991;40:934–8.Google Scholar
134. Kirmani, N, Tuazon, CU, Murray, HW, et al. Staphylococcus aureus carriage rate of patients receiving long-term hemodialysis. Arch Intern Med 1978;138:1657–9.CrossRefGoogle ScholarPubMed
135. Yu, VL, Goetz, A, Wagener, M, et al. Staphylococcus aureus nasal carriage and infection in patients on hemodialysis. N Engl J Med 1986;315:91–6.Google Scholar
136. Tuazon, CU. Skin and skin structure infection in the patient at risk: carrier state of Staphylococcus aureus . Am J Med 1984;76(Suppl 51):166–71.Google Scholar
137. Goldblum, SE, Ulrich, JA, Reed, WP. Nasal and cutaneous flora among hemodialysis patients and personnel: quantitative characterization and pattern of staphylococcal carriage. Am J Kidney Dis 1982;2:281–6.Google Scholar
138. Wurzel, CL, Halom, K, Feldman, JG, et al. Infection rates of Broviac-Hickman catheters and implantable venous devices. Am J Dis Child 1988;142:536–40.Google ScholarPubMed
139. Shapiro, ED, Wald, ER, Nelson, KA, et al. Broviac catheter-related bacteremia in oncology patients. Am J Dis Child 1982;136:679–81.Google Scholar
140. Press, OW, Ramsey, PG, Larson, EB, et al. Hickman catheter infections in patients with malignancies. Medicine (Baltimore) 1984;63:189200.CrossRefGoogle ScholarPubMed
141. Prince, A, Heller, B, Levy, J, et al. Management of fever in patients with central vein catheters. Pediatr Infect Dis 1986;5:20–4.Google Scholar
142. King, DR, Komer, M, Hoffman, J, et al. Broviac catheter sepsis: the natural history of an iatrogenic infection. J Pediatr Surg 1985;20:728–33.Google Scholar
143. Hartman, GE, Shochat, SJ. Management of septic complications associated with Silastic catheters in childhood malignancy. Pediatr Infect Dis J 1987;6:1042–7.Google Scholar
144. Ftynn, PM, Shenep, JL, Stokes, DC, et al. In situ management of confirmed central venous catheter-related bacteremia. Pediatr Infect Dis J 1987;6:729–34.Google Scholar
145. Rotstein, C, Brock, L, Roberts, RS. The incidence of first Hickman catheter-related infection and predictors of catheter removal in cancer patients. Infect Control Hosp Epidemiol 1995;16:451–8.Google Scholar
146. Schuman, ES. Outpatient management of Hickman catheter sepsis. Infect Surg 1987;6:103–9.Google Scholar
147. Reilly, JJ Jr Steed, DL, Ritter, PS. Indwelling venous access catheters in patients with acute leukemia. Cancer 1984;53:219–23.Google Scholar
148. Hickman, RO, Buckner, CD, Clift, RA, et al. A modified right atrial catheter for access to the venous system in marrow transplant recipients. Surg Gynecol Obstet 1979;148:871–5.Google Scholar
149. Lazarus, HM, Lowder, JN, Herzig, RH. Occlusion and infection in Broviac catheters during intensive cancer therapy. Cancer 1983;52:2342–8.Google Scholar
150. Simon, VC, Simon, M. Antibacterial activity of teicoplanin and vancomycin in combination with rifampicin, fusidic acid, or fosfomycin against staphylococci on vein catheters. Scand J Infect Dis Suppl 1990;72:14–9.Google Scholar
151. Guggenbichler, JP, Berchtold, D, Allerberger, FR, et al. In vitro and in vivo effect on antibiotics on catheters colonized by staphylococci. Eur J Clin Microbiol Infect Dis 1992;11:408–15.Google Scholar
152. De Arellano, ER, Pascual, A, Martinez-Martinez, L, et al. Activity of eight antibacterial agents on Staphylococcus epidermidis attached to Teflon catheters. J Med Microbiol 1994;40:43–7.CrossRefGoogle Scholar
153. Kropec, A, Huebner, J, Wursthorn, M, et al. In vitro activity of vancomycin and teicoplanin against Staphylococcus epidermidis colonizing catheters. Eur J Clin Microbiol Infect Dis 1993;12:545–8.Google Scholar
154. Pascual, A, Arellano, ER, Martinez-Martinez, L, et al. Effect of polyurethane catheters and bacterial biofilms on the in-vitro activity of antimicrobials against Staphylococcus epidermidis . J Hosp Infect 1993;24:211–8.Google Scholar
155. Sherertz, RJ. Pathogenesis of vascular catheter-related infections. In: Seifert, H, Jansen, B, Farr, BM, eds. Catheter-Related Infections. New York: Marcel Dekker, 1997:129.Google Scholar
156. Messing, B, Pietra-Cohen, S, Dubure, A, et al. Antibiotic-lock technique: a new approach to optimal therapy for catheter-related sepsis in home-parenteral nutrition patients. JPEN J Parenter Enteral Nutr 1988;12:185–9.Google Scholar
157. Douard, MC, Arlet, G, Leverger, G, et al. Quantitative blood cultures for diagnosis and management of catheter-related sepsis in pediatric hematology and oncology patients. Intensive Care Med 1991;17:30–5.Google Scholar
158. Cowan, C. Antibiotic lock technique. J Intraven Nurs 1992;15:283–7.Google Scholar
159. Krywda, E, Gotoff, R, Andris, D, et al. Antibiotic lock treatment (ALT): impact on catheter salvage and cost savings [abstract J4]. In: Program and Abstracts of the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy (San Francisco). Washington, DC: American Society for Microbiology, 1995.Google Scholar
160. Longuet, P, Douard, M, Maslo, C, et al. Limited efficacy of antibiotic lock techniques (ALT) in catheter related bacteremia of totally im-planted ports (TIP) in HW infected and oncologic patients [abstract J5]. In: Program and Abstracts of the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy (San Francisco). Washington, DC: American Society for Microbiology, 1995.Google Scholar
161. Elian, J, Frappaz, D, Ros, A, et al. Study of serum kinetics of vancomycin during the “antibiotic-lock” technique [in French]. Arch Fr Pediatr 1992;49:357–60.Google Scholar
162. Saxinger, LM, Williams, KE, Lyon, M, et al. Stability of antibiotics in heparin at 37°C: toward antibiotic locks for central venous catheter related infections [abstract 626]. In: Program and Abstracts of the 39th Interscience Conference on Antimicrobial Agents and Chemotherapy (San Francisco). Washington, DC: American Society for Microbiology, 1999.Google Scholar
163. Christensen, GD, Bisno, AL, Parisi, JT, et al. Nosocomial septicemia due to multiply antibiotic-resistant Staphylococcus epidermidis . Ann Intern Med 1982;96:110.CrossRefGoogle ScholarPubMed
164. Winston, DJ, Dudnick, DV, Chapin, M, et al. Coagulase-negative staphylococcal bacteremia in patients receiving immunosuppressive therapy. Arch Intern Med 1983;143:32–6.CrossRefGoogle ScholarPubMed
165. Sattler, FR, Foderaro, JB, Aber, RC. Staphylococcus epidermidis bacteremia associated with vascular catheters: an important cause of febrile morbidity in hospitalized patients. Infect Control 1984;5:279–83.Google Scholar
166. Sherertz, RJ, Falk, RJ, Thomann, CA, et al. Infections associated with subclavian Uldall catheters. Arch Intern Med 1983;143:52–6.Google Scholar
167. Engelhard, D, Elishoov, H, Strauss, N, et al. Nosocomial coagulase-negative staphylococcal infections in bone marrow transplantation recipients with central vein catheter. Transplantation 1996;61:430–4.Google Scholar
168. Rabinovich, S, Smith, I, January, LE. The changing patterns of bacterial endocarditis. Med Clin North Am 1968;52:1091–101.CrossRefGoogle ScholarPubMed
169. Lerner, P, Weinstein, L. Infective endocarditis in the antibiotic era. N Engl J Med 1966;274:388–93.Google Scholar
170. Hamburger, M. Treatment of bacterial endocarditis. Mod Treat 1964;1:1003–15.Google Scholar
171. Mylotte, J, McDermott, C, Spooner, JA. Prospective study of 114 consequences episodes of Staphylococcus aureus bacteremia. Rev Infect Dis 1987;9:891907.Google Scholar
172. Nolan, C, Beaty, H. Staphylococcus aureus bacteremia: current clinical patterns. Am J Med 1976;60:495500.Google Scholar
173. Iannini, P, Crossley, K. Therapy of Staphylococcus aureus bacteremia associated with a removable focus of infection. Ann Intern Med 1976;84:558–60.Google Scholar
174. Bayer, A, Tillman, D, Conception, N. Clinical value teichoic acid antibody titers in the diagnosis and management of the staphylococcemias. West J Med 1980;132:294300.Google Scholar
175. Ehni, W, Reller, L. Short-course therapy for catheter-associated Staphylococcus aureus bacteremia. Arch Intern Med 1989;149:533–6.Google Scholar
176. Jernigan, JA, Farr, B. Short course therapy of catheter related Staphylococcus aureus bacteremia: a meta-analysis. Ann Intern Med 1993;119:304–11.Google Scholar
177. Jacobson, M, Gellermann, H, Chambers, H. Staphylococcus aureus bacteremia and recurrent staphylococcal infection in patients with acquired immunodeficiency syndrome and AIDS related complex. Am J Med 1988;85:172–6.Google Scholar
178. Mortara, L, Bayer, A. Staphylococcus aureus bacteremia and endocarditis. Infect Dis Clin North Am 1993;7:5369.Google Scholar
179. Schrenzel, J, Schockmel, G, Bregenzer, T, et al. Severe staphylococcal infections: A randomized trial comparing quinolone + rifampin Civ then po) with conventional iv therapy [abstract 93]. In: Proceedings of the 36th Annual Meeting of the Infectious Diseases Society of America (San Francisco). Alexandria, VA: Infectious Diseases Society of America, 1998.Google Scholar
180. Dworkin, RJ, Lee, BL, Sande, MA, et al. Treatment of right sided Staphylococcus aureus endocarditis in intravenous drug users with ciprofloxacin and rifampicin. Lancet 1989;2:1071–3.Google Scholar
181. Heldman, AW, Hartert, TV, Ray, SC, et al. Oral antibiotic treatment of right-sided staphylococcal endocarditis in injection drug users: prospective randomized comparison with parenteral therapy. Am J Med 1996;101:6876.Google Scholar
182. Acocella, G. Pharmacokinetics and metabolism of rifampin in humans. Rev Infect Dis 1983;5(Suppl 3):S428–32.CrossRefGoogle ScholarPubMed
183. Farr, BM. Rifamycins. In: Mandell, GL, Douglas, RG Jr Bennett, JE, eds. Principles and Practice of Infectious Diseases. 5th ed. New York: John Wiley & Sons, 2000:348–61.Google Scholar
184. Rose, HD. Venous catheter-associated candidemia. Am J Med Sci 1978;275:265–9.Google Scholar
185. Anaissie, EJ, Vartivarian, SE, Abi-Said, D, et al. Fluconazole versus amphotericin B in the treatment of hematogenous candidiasis: a matched cohort study. Am J Med 1996;101:170–6.Google Scholar
186. Eppes, SC, Troutman, H, Gutman, LT. Outcome of treatment of candidemia in children whose central catheters were removed or retained. Pedtatr Infect Dis 1989;8:99104.Google Scholar
187. Dato, VM, Dajani, AS. Candidemia in children with central venous catheters: role of catheter removal and amphotericin B therapy. Pediatr Infect Dis J 1990;9:309–14.Google Scholar
188. Lecciones, JA, Lee, JW, Navarro, EE, et al. Vascular catheter-associated fungemia in patients with cancer: analysis of 155 episodes. Clin Infect Dis 1992;14:875–83.Google Scholar
189. Kulak, K, Maki, DG. Treatment of Hickman catheter-related candidemia without removing the catheter [abstract 832]. In: Program and Abstracts of the 32nd Interscience Conference on Antimicrobial Agents and Chemotherapy (Anaheim, CA). Washington, DC: American Society for Microbiology, 1992.Google Scholar
190. Anaissie, E, Rex, JH, Uzun, O, et al. Prognosis and outcome of candidemia in cancer patients. Am J Med 1998;104:238–45.Google Scholar
191. Baltimore, RS. Neonatal nosocomial infections. Semin Perinatol 1998;22:2532.Google Scholar
192. Weiner, ES. Catheter sepsis: the central venous line Achilles' heel. Semin Pediatr Surg 1995;4:207–14.Google Scholar
193. Weiner, ES, McGuire, P, Stolar, CJH, et al. The CCSG prospective study of venous access devices: an analysis of insertions and causes for removal. J Pediatr Surg 1992;27:155–64.Google Scholar
194. Wang, EEL, Prober, CG, Ford-Jones, L, Gold, R. The management of central venous catheter infections. Pediatr Infect Dis 1984;3:110–3.Google Scholar
195. Nahata, MC, King, DR, Powell, DA, et al. Management of catheter related infections in pediatric patients. JPEN J Parenter Enteral Nutr 1988;12:58–9.CrossRefGoogle ScholarPubMed
196. Stovroff, M, Teague, WG. Intravenous access in infants and children. Pediatr Clin North Am 1998;45:1373–93.Google Scholar
197. National Nosocomial Infection Surveillance System. National nosocomial infection surveillance (NNIS) report, data summary from January 1992-April 2000, issued June 2000. Am J Infect Control 2000;28:429–48.Google Scholar
198. Gaynes, RP, Edwards, JR, Jarvis, WR, et al. Nosocomial infections among neonates in high-risk nurseries in the United States. Pediatrics 1996;98:357–61.Google Scholar
199. Huskins, WC, Goldmann, DA. Nosocomial infections. In: Feigin, RD, Cherry, JD, eds. Textbook of Pediatric Infectious Diseases. Philadelphia: WB Saunders, 1998:2545–85.Google Scholar
200. Freeman, J, Platt, R, Epstein, MF, et al. Coagulase-negative staphylococcal bacteremia in the changing neonatal intensive care unit population: is there an epidemic? JAMA 1987;258:2548–52.Google Scholar
201. Decker, MD, Edwards, KM. Central venous catheter infections. Pediatr Clin North Am 1988;35:579612.Google Scholar
202. Jones, GR, Konsler, GK, Dunaway, RP, et al. Prospective analysis of urokinase in the treatment of catheter sepsis in pediatric hematologyoncology patients. J Pediatr Surg 1993;28:350–7.Google Scholar
203. Lacey, SR, Zantsky, A, Azizhan, RG. Successful treatment of Candida infected caval thrombus in critically ill infants by low dose streptokinase infusion. J Pediatr Surg 1988;23:1204–7.Google Scholar
204. Khan, EA, Correa, AG, Baker, CJ. Suppurative thrombophlebitis in children: a ten-year experience. Pediatr Infect Dis J 1997;16:63–7.CrossRefGoogle ScholarPubMed
205. Graham, DR. Nosocomial fungemia in a normal host. JAMA 1983;250:2791.Google Scholar
206. Wilkins, EGL, Manning, D, Roberts, RC, et al. Quantitative bacteriology of peripheral venous cannulae in neonates. J Hosp Infect 1985;6:209–17.CrossRefGoogle ScholarPubMed
207. Raad, I, Narro, J, Khan, A, et al. Serious complications of vascular catheter-related Staphylococcus aureus bacteremia in cancer patients. Eur J Clin Microbiol Infect Dis 1992;11:675–82.Google Scholar
208. Kentos, A, Dufaye, P, Jacobs, F, et al. Candida albicans septic thrombosis of the right atrium is associated with a central venous catheter. Clin Infect Dis 1995;21:440–2.Google Scholar
209. Benoit, D, Decruyenaere, J, Vandewoude, K, et al. Management of candidal thrombophlebitis of the central veins: case report and review. Clin Infect Dis 1998;26:393–7.Google Scholar
210. Eggimann, P, Harbarth, S, Constantin, MN, Touveneau, S, Chevrolet, JC, Pittet, D. Impact of a prevention strategy targeted at vascular-access care in incidence of infections acquired in intensive care. Lancet 2000;355:1864–8.Google Scholar