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Failure of Oral Antimicrobial Agents in Eradicating Gastrointestinal Colonization With Vancomycin-Resistant Enterococci

Published online by Cambridge University Press:  02 January 2015

Ray Hachem  and
Issam Raad
Ray Hachem
Affiliation:
Section of Infection Control, Department of Internal Medicine Specialties, The University of Texas M.D. Anderson Cancer Center, Houston, Texas
Issam Raad*
Affiliation:
Section of Infection Control, Department of Internal Medicine Specialties, The University of Texas M.D. Anderson Cancer Center, Houston, Texas
*
Professor of Medicine, The University of Texas M.D. Anderson Cancer Center, Department of Infection Diseases, Infection Control and Employee Health (Box 402), 1515 Holcombe Blvd., Houston, TX 77030
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Abstract

Eradication of gastrointestinal colonization with vancomycin-resistant enterococci (VRE) using a combination of oral bacitracin and gentamicin was evaluated. Twenty-eight evaluable treated patients were matched with 28 control patients. After 3 months of follow-up, 5 patients (18%) in the treatment group versus 1 patient (4%) in the control group (P = .2) had negative results on stool cultures, with a similar frequency of VRE bacteremia (P = .8). The use of oral bacitracin plus gentamicin did not reduce VRE colonization or bacteremia.

Type
Concise Communications
Information
Infection Control & Hospital Epidemiology , Volume 23 , Issue 1 , January 2002 , pp. 43 - 44
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2002

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