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The Enterococcus

Published online by Cambridge University Press:  02 January 2015

Robert M. Gullberg
Robert M. Gullberg*
Affiliation:
Northwestern University Medical School, Section of Infectious Disease, Department of Medicine, Chicago, Illinois
*
Racine Medical Clinic, 5625 Washington Avenue, Racine, Wisconsin 53406
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Extract

In 1899, Thiercilin used the term “enterococcus” to describe microscopic organisms seen in pairs or short chains in feces. Later (in the 1930s) the name was used in a more restrictive sense for streptococci that had the hardy capacity to survive under extreme conditions.

Enterococci belong to a group D family of streptococci, as characterized by Lancefield in 1938. In contrast to other groups of streptococci, the group D antigen is not a wall carbohydrate but a glycerol teichoic acid containing glucose and D-alanine. This antigen appears to be related directly to the cytoplasm or plasma membrane.

Type
Special Sections
Information
Infection Control & Hospital Epidemiology , Volume 7 , Issue 12 , December 1986 , pp. 600 - 606
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1986

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References

1. Thiercelin, ME: C R Soc Biol 1899; 5:269.Google Scholar
2. Sherman, JM: Bact Review 1937; 1:3.Google Scholar
3. Braude, A, Davis, C, Fierer, J (eds): Infectious Disease and Medical Microbiology. Philadelphia, WB Saunders, 1985; p 250.Google Scholar
4. Wolfgang, Joklik W (eds): Zinsser Microbiology, 18 ed. New York, Appleton and Lang, 1984; pp 472–473.Google Scholar
5. Mandell, GL, Douglas, RG, Bennett, JE (eds): Principles and Practice of Infectious Diseases, ed 2. New York, John Wiley and Sons Inc, 1985, pp 1152–1155.Google Scholar
6. Moellering, RD, Korzeniowski, OM, Sande, MA, et al: Species-specific resistance to antimicrobial synergism in Streptococcus faecium and Streptococcus faecalis . J Infect Dis 1979; 140:203–208.CrossRefGoogle ScholarPubMed
7. Nowlan, SS, Deibel, RH: Group Q streptococci. I. Ecology, serology, physiology, and relationship to established enterococci. J Bact 1967; 94:291.CrossRefGoogle Scholar
8. Milgram, F, Flanagan, T (eds): Medical Microbiology. New York, Churchill, 1982; p 272–275.Google Scholar
9. Gross, KC, Houghton, MP, Senterfit, LB: Presumptive speciation of Streptococcus bovis and other group D streptococci from human sources by using arginine and pyruvate tests. J Clin Microbiol 1975; 1:54.Google Scholar
10. Mundt, JO: Occurrence of enterococci: Bud, bloom and soil studies. Appl Microbiol 1961; 9:541–544.Google Scholar
11. Langston, CW, Guttierez, J, Bauma, C: Motile enterococci (Streptococcus faecium van mobilus var. n) isolated from gross soilage. J Bact 1960; 80:714.Google Scholar
12. Graudal, H: The classification of motile streptococci within the enterococcus group. Acta Path Microbiol Scand 1957; 41:403.Google Scholar
13. Finegold, S, Martin, WJ (eds): Bailey and Scott's Diagnostic Microbiology, ed 6. St. Louis, CV Mosby, 1982, p 178.Google Scholar
14. Washington, JA II, Martin, WJ, Karlson, AG: Identification of bacteria, in Washington, JA II (ed): Laboratory Procedures in Clinical Microbiology. Boston, Little Brown & Co, 1974, pp 53–124.Google Scholar
15. Wilkowske, CJ: Enterococcal endocarditis. Mayo Clin Proc 1982; 57:101–105.Google ScholarPubMed
16. Deibel, RH: The group D streptococci. Bacterial Rev 1964; 28:330.Google Scholar
17. Brock, TD, Peacher, B, Pierson, D: Survey of the bacteriocines of enterococci. J Bact 1963; 86:702.Google Scholar
18. Levison, ME, Kaye, D: Fecal flora in man: Effect of cathartic. J Infect Dis 1969; 119:591–596.CrossRefGoogle ScholarPubMed
19. Mead, GC: in Skinner, FA, Quesnel, LB (eds): Streptococci. London, Academic Press, 1978, p 245. Google ScholarPubMed
20. Van der Wiel-korstanje, JAA, Winkler, KC: The fecal flora in ulcerative colitis. J Med Microbiol 1975; 8:491.Google Scholar
21. Nord, CE, Wadstrom, T: Characterization of hemolytic enterococci isolated from oral infections. Acta Odontol Scand 1973; 31:387.Google Scholar
22. Tefft, HI, Bibby, BG: Streptococci isolated from the mouth. J Dent Res 1940; 19:285.Google Scholar
23. Adhami, Z: The beta-lactamase activity of the vaginal flora of asymptomatic pregnant women. J Antimicrob Chemother 1982; 10:303–309.CrossRefGoogle ScholarPubMed
24. Koenig, GM, Kaye, D: Enterococcal endocarditis: Report of 19 cases with longterm follow-up data. N Engl J Med 1961; 264:257–264.Google Scholar
25. Kaye, D: Enterococci. Arch Intern Med 1982; 142:2006–2009.Google Scholar
26. Tomasz, A, Albino, A, Zanati, E: Multiple antibiotic resistance in a bacterium with suppressed autolytic system. Nature 1970; 227:138–140.Google Scholar
27. Gootz, TD, Sanders, CC, Sanders, WE: In vitro activity of furazlocillin (Bay K4999) compared with those of mezlocillin, piperacillin, and stable Betalactam antibiotics. Antimicrob Agents Chemother 1979; 15:783–791.CrossRefGoogle Scholar
28. Robinson, RG, Saunders, J, Cassel, R, et al: Comparative in vitro appraisal of piperacillin, including its activity against Salmonella. Antimicrob Agents Chemother 1980; 18:493–501.Google Scholar
29. Kuck, NA, Redin, GS: In vitro and in vivo activity of piperacillin: A broad spectrum semisynthetic penicillin. J Antibiot 1978; 31:33–41.Google Scholar
30. Tofte, RW, Solliday, J, Crossley, KB: Susceptibilities of enterococci to twelve antibiotics. Antimicrob Agents Chemother 1984; 25:532–553.CrossRefGoogle ScholarPubMed
31. Finland, M: Changing patterns of susceptibility of common bacterial pathogens to antimicrobial agents. Ann Intern Med 1972; 76:1009.CrossRefGoogle ScholarPubMed
32. Dickinson, GM, Cleary, TJ, Hoffman, TA: Comparative evaluation of piperacillin in vitro. Antimicrob Agents Chemother 1978; 14:919–921.Google Scholar
33. Reimer, LG, Mirrett, S, Reller, LB: Comparison of moxalactam (LY 127935) with cefazolin, amikacin, tobramycin, carbenicillin, piperacillin and ticarcillin against 420 blood culture isolates. Antimicrob Agents Chemother 1980; 17:412–416.Google Scholar
34. Verbist, L: In vitro activity of piperacillin: A new semisynthetic penicillin with an unusually broad spectrum of activity. Antimicrob Agents Chemother 1978;13:349–357.Google Scholar
35. Mandell, GL, Lindsey, E, Hook, EW: Synergism of vancomycin and streptomycin for enterococci. Am J Med Sci 1970;259:346–349.CrossRefGoogle ScholarPubMed
36. Standiford, HD, deMaine, JB, Kirby, WMM: Antibiotic synergism of enterococci: Relation to inhibitory concentrations. Arch Intern Med 1970;126:255–259.Google Scholar
37. Mandell, GL: Enterococcal endocarditis, in Kaye, D (ed): Infective Endocarditis. Baltimore, University Park Press, 1976, pp 101–110.Google Scholar
38. Moellering, RC Jr, Wennersten, C, Weinstein, AJ: Penicillin-tobramycin synergism against enterococci: A comparison with penicillin and gentamicin. Antimicrob Agents Chemother 1973;3:526–529.Google Scholar
39. Watanakunakorn, C: Penicillin combined with gentamicin or streptomycin: Synergism against enterococci. J Infect Dis 1971;124:581–586.Google Scholar
40. Zimmerman, RA, Moellering, RC Jr, Weinberg, AN: Mechanism of resistance to antibiotic synergism in enterococci. J Bacteriol 1971;105:873–879.Google Scholar
41. Bryan, CS, Reynolds, KL, Brown, JJ: Mortality associated with enterococcal bacteremia. Surg Gynecol Obstet 1985;160:557–561.Google Scholar
42. Garrison, RN, Fry, DE, Berberich, S, et al: Enterococcal bacteremia: Clinical implications and determinants of death. Ann Surg 1982;196:43–47.Google Scholar
43. Dougherty, S, Flohr, A, Simmons, RL: Breakthrough enterococcal septicemia in surgical patients: 19 cases and a review of the literature. Arch Surg 1983;118:232–237.CrossRefGoogle Scholar
44. Barrall, DT, Kenney, PR, Slotman, GJ, et al: Enterococcal bacteremia in surgical patients. Arch Surg 1985;120:57–63.Google Scholar
45. Shlaes, DM, Levy, J, Wolinsky, E: Enterococcal bacteremia without endocarditis. Arch Intern Med 1981;141:578–581.Google Scholar
46. Klimek, JJ, Ajemion, E, Gracewski, J, et al: Enterococcal infections in a large community hospital with emphasis on bacteremia. Am J Infect Control 1980;8:58–61.Google Scholar
47. Whiteside, M, Moore, J, Ratzam, K: An investigation of enterococcal bacteremia. Am J Infect Control 1983;11:125–129.Google Scholar
48. Mandell, GL, Kaye, D, Levison, ME, et al: Enterococcal endocarditis: Analysis of 38 patients observed at the New York Hospital-Cornell Medical Center. Arch Intern Med 1970;125:258–264.Google Scholar
49. Schoenbaum, SC, Gardner, P, Shillito, J: Infections of CSF shunts: Epidemiology, clinical manifestations and therapy. J Infect Dis 1975;131:543–553.Google Scholar
50. Ryan, JL, Pachner, A, Andriole, VT, et al: Enterococcal meningitis: Combined vancomycin and rifampin therapy. Am J Med 1980;68:449–451.Google Scholar
51. Bayer, AS, Seidel, JS, Yoshikawa, T, et al: Group D enterococcal meningitis. Arch Intern Med 1976;136:883–886.Google Scholar
52. Pitt, HA, Posstier, RG, Cameron, JL: Postoperative T-tube cholangiography. Ann Surg 1980;191:30–34.CrossRefGoogle ScholarPubMed
53. Morrow, DJ, Thompson, J, Wilson, SE: Acute cholecystitis in the elderly. Arch Surg 1978;113:1149–1152.CrossRefGoogle ScholarPubMed
54. Shimada, K, Inamatsu, T, Yamashiro, M: Anaerobic bacteria in biliary disease in elderly patients. J Infect Dis 1977;135:850–854.Google Scholar
55. Jackaman, FR, Triggs, CM, Thomas, V: Experimental bacterial infection of the biliary tract. Br J Exp Pathol 1980;61:369–375.Google Scholar
56. Blenkhorn, JI, Blumgart, LH: Streptococcal bacteremia in hepatobiliary operations. Surg Gynecol Obstet 1985;160:139–141.Google Scholar
57. Berk, SL, Verghese, A, Holtsclaw, SA, et al: Enterococcal pneumonia. Am J Med 1983;74:153–154.CrossRefGoogle ScholarPubMed
58. Sande, MA: Antimicrobial therapy for two serious bacterial infections: Enterococcal endocarditis and nosocomial pneumonia. Arch Intern Med 1982; 142:2033–2044.Google Scholar
59. Nolte, WA (ed): Oral Microbiology with Basic Microbiology and Immunology, ed4. St. Louis, CV Mosby, 1982, pp 298–300.Google Scholar
60. Lewis, JF, Johnson, P, Miller, P: Evaluation of amniotic fluid for aerobic and anaerobic bacteria. Am J Clin Pathol 1976;65:58–63.Google Scholar
61. Bavikatte, K, Schreiner, RL, Lemons, JA, et al: Group D streptococcal septicemia in the neonate. Am J Dis Child 1979;133:493–496.Google Scholar
62. Buchino, JJ, Ciambarella, E, Light, I: Systemic group D streptococcal infection in newborn infants. Am J Dis Child 1979;133:270–273.Google Scholar
63. Beargie, R, Lynd, P, Tucker, E, et al: Perinatal infection and vaginal flora. Am J Obstet Gynecol 1975;122:31–33.Google Scholar
64. Gross, PE, Harkavy, LM, Barden, GE, et al: The epidemiology of nosocomial enterococcal urinary tract infection. Am J Med Sci 1976;272:75–81.Google Scholar
65. Faro, S, Pastorek, J: The enterococcus: Myth or reality in ob/gyn infections. Infect Surg 1983;11:787–794.Google Scholar
66. Horvitz, R, Von Granenitz: A clinical study of the role of enterococci as sole agents of wound and tissue infections. Yale J Biol Med 1977;50:391–395.Google Scholar
67. Rantz, L, Kirby, W: Enterococci infections: An evaluation of the importance of fecal streptococcal and related organisms in the causation of human disease. Arch Intern Med 1943;17:516–528.Google Scholar
68. Freischlag, J, McGrattan, M, Busuttil, R: The clinical significance of enterococcus in surgical infections. Abstract #16. Presented at Surgical Infection Society, Florida, 1983.Google Scholar
69. Bartlett, J, Louie, T, Onderdonk, A, et al: Whither the enterococcus? Abstract #297. Interscience Conference Antimicrobial Agents and Chemotherapy, 1975.Google Scholar
70. Bartlett, JG, Onderdonk, AB, Louie, T, et al: A review: Lessons from an animal model of intra-abdominal sepsis. Arch Surg 1978;113:850–857.Google Scholar
71. Levison, ME: Peritonitis and intra-abdominal abscess, in Mandell, G, Douglas, RG, Bennett, JE (eds): Principles and Practice of Infectious Diseases. New York, John Wiley and Sons Inc, 1985.Google Scholar
72. Bohnen, JM, Matlow, A, Nohr, CW, et al: Pathogenicity of enterococcus in a rat model of fecal peritonitis. Abstract #276. Interscience Conference Antimicrobial Agents and Chemotherapy, 1983.Google Scholar
73. Crenshaw, C, Glanges, E, Webber, C, et al: A prospective random study of a single agent vs. combination antibiotics as therapy in penetrating inquiries of the abdomen. Surg Gynecol Obstet 1983;3:289–294.Google Scholar
74. Levison, ME, Santoro, J, Bran, JL, et al: In vitro activity and clinical efficacy of clindamycin in the treatment of infections due to anaerobic bacteria, abstracted. J Infect Dis 1977; 135:549.Google Scholar
75. Berne, TV, Yellin, AW, Appleman, MD, et al: Antibiotic management of surgically treated gangrenous or perforated appendicitis. Am J Surg 1982;144:8–13.Google Scholar
76. Yu, VL: Enterococcal superinfection and colonization after therapy with moxalactam, a new broad-spectrum antibiotic. Ann Intern Med 1981;94:784–785.Google Scholar
77. Chempakanallore, TT, Berk, S, Eapen, T: Enterococcal liver abscess associated with moxalactam therapy. Arch Intern Med 1983;143:1780–1781.Google Scholar
78. Marier, RL, Faro, S, Sanders, CV, et al: Moxalactam in the therapy of serious infections. Antimicrob Agents Chemother 1982;21:650–654.Google Scholar
79. Mickal, A, Carole, D, Lewis, C: Cefoxitin sodium: Double-blind vaginal hysterectomy prophylaxis in premenopausal patients. Obstet Gynecol 1980;56:222–225.Google Scholar
80. Ilstrup, DM: Organisms from blood cultures at the Mayo Clinic: 1968-1975, in Washington, JA (ed): The Detection of Septicemia. West Palm Beach, CRC Press, 1978, pp 23–25.Google Scholar
81. Beaman, KD, Kasten, BL, Gavan, RL: Rate of detection of bacteremia. Cleve Clin Q 1977;44:129–136.Google Scholar
82. Weinstein, MP, Reller, LB, Murphy, JR, et al: The clinical significance of positive blood cultures. A comprehensive analysis of 500 episodes of bacteremia and fungemia in adults—I. Laboratory and epidemiologic observations. Rev Infect Dis 1983;5:35–53.Google Scholar
83. Jones, R: Antibiotics in trauma. J Surg Pract 1977; September-October.Google Scholar
84. Ledger, WJ, Norman, M, Gee, C, et al: Bacteremia on an obstetric-gynecologic service. Am J Obstet Gynecol 1975;121:205–212.Google Scholar
85. Duma, RJ, Weinberg, AN, Medrek, TF, et al: Streptococcal infections. Medicine 1969;48:87–127.Google Scholar
86. Jarvinen, H, Renkonen, OV, Palmer, A: Antibiotics in acute cholecystitis. Ann Clin Res 1978;10:247–251.Google Scholar
87. Krieghley, MR: Preventing infection in biliary surgery. Infect Surg 1983;2:711–719.Google Scholar
88. Keighley, MR, Baddeley, RM, Burdon, DW: A controlled trial of parenteral prophylactic gentamicin therapy in biliary surgery. Br J Surg 1975;62:275–279.Google Scholar
89. Karran, S, Moore, PL, Goh, H: Three year experience with single dose cephalosporin prophylaxis in biliary surgery in: Controversies in Surgical Sepsis. Surgical Science Series. New York, Praeger Scientific, 1980, vol 1, pp 293–301.Google Scholar
90. Morris, DL, Mojaddedi, ZJ, Burdon, DW: Clinical and microbiological evaluation of piperacillin in elective biliary surgery. J Hosp Infect 1983;4:159–164.Google Scholar
91. Annual Summary—Nosocomial Infection Surveillance, 1983. MMWR 1984; 33(2SS):9SS–21SS.Google Scholar
92. Warren, JW, Tenney, JH, Hoopes, JM: A prospective microbiologic study of bacteriuria in patients with chronic indwelling urethral catheters. J Infect Dis 1982; 146:719.Google Scholar
93. Stamey, TA, Sexton, CC: The role of vaginal colonization with enterobacteriaceae in recurrent urinary infections. J Urol 1975; 113:214.Google Scholar
94. Harding, GKM, Ronald, AR: A controlled study of antimicrobial prophylaxis of recurrent urinary infection in women. N Engl J Med 1974; 291:597.CrossRefGoogle ScholarPubMed
95. Meares, EM, Barbalias, GA: Prostatitis: Bacterial, nonbacterial, and prostatodynia. Semin Urol 1983;1:149–150.Google Scholar
96. Fair, W, Couch, J, Wehner, N: Prostatic antibacterial factor—Identity and significance. J Urol 1976;76:169–177.Google Scholar
97. Berman, RS, Eiscle, JM: Bacteremia, spinal anesthesia and development of meningitis. Anesthesiology 1978;48:376–378.Google Scholar
98. Fox, J, Isenberg, HD: Antibiotic resistance of microorganisms isolated from root canals. Oral Surg 1967; 23:230.Google Scholar
99. Holden, HB, Durcan, DJ: Osteomyelitis of the maxilla. J Laryngol Otol 1963; 77:1021.Google Scholar
100. Mason, DA: Steroid therapy and dental infection: Case report. Br Dent J 1970; 122:271.Google Scholar
101. Falace, DA, Ferguson, TW: Bacterial endocarditis: Survey of patients between 1963 and 1975. Oral Surg 1976; 42:189.Google Scholar
102. Rahal, JJ, Meyers, BR, Weinstein, L: Treatment of bacterial endocarditis with cephalothin. N Engl J Med 1968; 279:1305–1309.Google Scholar
103. Carrizosa, J, Kaye, D: Antibiotic synergism in enterococcal endocarditis. J Lab Clin Med 1976; 88:132–141.Google Scholar
104. Serra, P, Brandimarte, C, Martino, P, et al: Synergistic treatment of enterococcal endocarditis: In vitro and in vivo studies. Arch Intern Med 1977; 137:1562–1567.Google Scholar
105. Wilkowske, CJ, Facklam, RR, Washington, JA II, et al: Antibiotic synergism: Enhanced susceptibility of group D streptococci to certain antibiotic concentrations. Antimicrob Agents Chemother 1971; 195–200.Google Scholar
106. Moellering, RC Jr, Wennersten, C, Medrek, T, et al: Prevalence of high level resistance to aminoglycosides in clinical isolates of enterococci. Antimicrob Agents Chemother 1970; 10:335–340.Google Scholar
107. Krogstad, DJ, Korfhagen, TR, Moellering, RC Jr, et al: Aminoglycoside inactivating enzymes in clinical isolates of Streptococcus faecalis: An explanation for resistance to antibiotic synergism. J Clin Invest 1978; 62:480–486.Google Scholar
108. Marder, HP, Kayser, FH: Transferable plasmids mediating multiple antibiotic resistance in Streptococcus faecalis subsp liquefaciens. Antimicrob Agents Chemother 1977; 12:267–269.Google Scholar
109. Krogstad, DK, Korfhagen, TR, Moellering, RC Jr, et al: Plasmid-mediated resistance to antibiotic synergism in enterococci. J Clin Invest 1978; 61:1645–1653.Google Scholar
110. Courvalin, PM, Shaw, WV, Jacob, AE: Plasmid-mediated mechanisms of resistance to aminoglycoside-aminocyclitol antibiotics and to chloramphenicol in group D streptococci. Antimicrob Agents Chemother 1978; 13:716–725.Google Scholar
111. Moellering, RC Jr, Murray, BE, Schoenbaum, SC, et al: A novel mechanism of resistance to penicillin-gentamicin synergism in Streptococcus faecalis . J Infect Dis 1980; 141:81–86.Google Scholar
112. Horodniceanu, T, Bougneleret, L, El-Solh, N, et al: High-level, plasmid-borne resistance to gentamicin in Streptococcus faecalis subsp zymogenes. Antimicrob Agents Chemother 1979; 16:686–689.Google Scholar
113. Yuv, V (mod): Enterococcus: An emerging pathogen, an overview. Infect in Surg 1984; (special supp), p 19.Google Scholar
114. Westenfelder, GO, Paterson, PY, Reisberg, BE, et al: Vancomycin-streptomycin synergism in enterococcal endocarditis. JAMA 1973; 223:37–40.Google Scholar
115. Hook, EW III, Johnson, WD Jr: Vancomycin therapy of bacterial endocarditis. Am J Med 1978; 65:411–415.Google Scholar
116. Cook, FV, Coddington, CC, Wadland, NC, et al: Treatment of bacterial endocarditis with vancomycin. Am J Med Sci 1978; 276:153–158.Google Scholar
117. Farber, BF, Moellering, RC Jr: Retrospective study of the toxicity of vancomycin from 1974–1981. Antimicrob Agents Chemother 1983; 23:138–141.Google Scholar
118. Gross, MH, Barriere, SL: Pathogenesis and treatment of enterococcal infections. Clin Pharm 1984; 3:161–166.Google Scholar