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Efforts to regulate antibiotic misuse in hospitals: A history

Published online by Cambridge University Press:  30 July 2021

Powel H. Kazanjian Open the ORCID record for Powel H. Kazanjian [Opens in a new window]
Powel H. Kazanjian*
Affiliation:
Division of Infectious Diseases, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA
*
Author for correspondence: Powel H. Kazanjian E-mail: [email protected]
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Abstract

Today, most hospitals have implemented regulatory programs designed to curtail the antimicrobial misuse that has fueled resistance. In this paper, I trace the history of resistance and efforts to mitigate antibiotic overuse in the hospital. Medical investigators in the 1950s argued that the difficulties posed by resistant bacteria in the hospital were even more worrisome than the problems that antibiotics were intended to solve. These investigators sought to reform physician habits that they believed, left unchecked, would accelerate resistance and hasten the end of the antibiotic era. When their methods of education failed to change physician’s prescribing habits voluntarily, external restrictions were imposed. Today’s antimicrobial stewardship programs represent the newest version of a series of efforts that began in the mid-twentieth century to reform antibiotic misuse and to control resistant microbes in the hospital.

Type
Original Article
Information
Infection Control & Hospital Epidemiology , Volume 43 , Issue 9 , September 2022 , pp. 1119 - 1122
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Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America

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References

Kossiakoff, MG. De la propriete qui possedent les microbes de s’accomoder aux milieux antiseptiques. Ann Instit Pasteur 1887;1:465–473.Google Scholar
Ehrlich, P. Ueber modern chemotherapie. Tagung der Deutschen Dermatologischen Gesellschaft. Beitrage zur experimentellen Pathologie Chemotherapie 1909;7:53–69.Google Scholar
Morgenroth, J, Levy, R. Chemotherapie der pneumokokkeninfection. Berl kiln Wshnschr 1911;48:1560.Google Scholar
Moore, H, Chesney, A. A study of ethyylhdrocuprein (optochin) in the treatment of acute lobar pneumonia. Arch Intern Med 1917;19:611–682.CrossRefGoogle Scholar
MacLean, IH, Rogers, KB, Fleming, AM. 693 and pneumococci. Lancet 1939;1:562.CrossRefGoogle Scholar
Abraham, EP, Chain, E, Fletcher, CM, et al. Further observations on penicillin. Lancet 1941;11:177.CrossRefGoogle Scholar
Rammelkamp, CH, Maxon, T. Resistance of Staphylococcus aureus to action of penicillin. Proc Soc Exper Biol Med 1942;51:386–389.CrossRefGoogle Scholar
Abraham, EP. The development of drug resistance in microorganisms. In: Gale, EF, Davies, R, editors. Adaptation in Microorganisms. The Third Symposium of the Society for General Microbiology. Cambridge, UK: Cambridge University Press; 1953:201–224.Google Scholar
Rouche, B. Something Extraordinary. In: Eleven Blue Men. New York: Berkley; 1946:139–158.Google Scholar
Gradmann, C. Re-inventing infectious diseases. Antibiotic resistance and drug development at the Bayer company, 1945–1980. Med Hist 2016;60:155–180.CrossRefGoogle Scholar
Scheckler, WE, Bennett, JV. Antibiotic usage in seven community hospitals. JAMA 1970;213:264–267.CrossRefGoogle ScholarPubMed
Finland, M, Weinstein, L. Complications induced by antimicrobial agents. N Engl J Med 1953;248:220–226.CrossRefGoogle ScholarPubMed
Reimann, HA. The misuse of antimicrobics. Med Clin North Am 1961;45:849–856.CrossRefGoogle ScholarPubMed
Dowling, HF, Lepper, MH, Jackson, GG. Clinical significance of antibiotic resistant bacteria. JAMA 1955;157:327–337.CrossRefGoogle ScholarPubMed
Lepper, M. Microbial resistance to antibiotics. Ann Int Med 1955;43:299–315.Google ScholarPubMed
Finland, M. Treatment of pneumonia and other serious infections. N Engl J Med 1960;263:207–221.CrossRefGoogle ScholarPubMed
Fleming, A. Penicillin, Nobel lecture, December 11, 1945. In: Nobel Lectures in the Physiology of Medicine. Singapore: World Scientific; 1999;83–93.Google Scholar
Dubos, R. Mirage of Health. New York: Anchor Books 1959;1–235.Google Scholar
Finland, M. Emergence of antibiotic-resistant bacteria. N Engl J Med 1955;253:909–922, 969–978, 1019–1028.CrossRefGoogle ScholarPubMed
Moser, RH. Major diseases of medical progress. N Engl J Med 1956; 255: 606–614.CrossRefGoogle Scholar
Finland, M. Changing ecology of bacterial infections as related to antibacterial therapy. J Infect Dis 1970;122:419–431.CrossRefGoogle ScholarPubMed
Finland, M. Emergence of antibiotic resistance in hospitals, 1935–1975. Rev Infect Dis 1979;1:4–22.CrossRefGoogle ScholarPubMed
Kunin, CM, Tupasi, T, Craig, WA. Use of antibiotics: a brief exposition of the problem and some tentative solutions. Ann Intern Med 1973;79:555–560.CrossRefGoogle ScholarPubMed
Kunin, C. Antibiotic armageddon. Clin Infect Dis 1997;25:240–241.CrossRefGoogle ScholarPubMed
Powers, JH. Antimicrobial drug development—the past, the present, and the future. Clin Microbiol Infect 2004;10:23–31.CrossRefGoogle ScholarPubMed
Weber, JT, Courvalin, P. An emptying quiver: antimicrobial drugs and resistance. Emerg Infect Dis 2005;6:791–793.CrossRefGoogle Scholar
Rex, J, Eisenstein, B, Alder, J, et al. A comprehensive regulatory framework to address the unmet need for new antibacterial treatments. Lancet Infect Dis 2013;13:269–275.CrossRefGoogle ScholarPubMed
Laxminarayan, R, Duse, A, Wattal, et al. Antibiotic resistance—the need for global solutions. Lancet Infect Dis 2013;13:1057–1098.CrossRefGoogle ScholarPubMed
Barber, M, Dutton, MA, Beard, MA, Elmes, PC, Williams, R. Reversal of antibiotic resistance in hospital staphylococcal infection. Br Med J 1960;2:11–17.CrossRefGoogle Scholar
McGowan, JE, Finland, M. Usage of antibiotics in a general hospital: effect of requiring justification. J Infect Dis 1974;130:165–168.CrossRefGoogle Scholar
American Hospital Association. Prevention and control of Staphylococcus infections in hospitals. In: Proceedings of the National Conference on Hospital-Acquired Staphylococcal Disease. Atlanta: CDC; 1958:XXIII–XXVI.Google Scholar
Scheckler, WE, Garner, JS, Kaiser, AB, et al. Prevalence of infections and antibiotic usage in eight community hospitals. In: Proceedings of the National Conference on Hospital-Acquired Staphylococcal Disease. Atlanta: CDC; 1970:299–305.Google Scholar
Hughes, J. Nosocomial infection surveillance in the United States: historical perspective. Infect Control 1987;8:450–453.CrossRefGoogle ScholarPubMed
Klapp, DL, Ramphal, R. Antibiotic restriction in hospitals associated with medical schools. Am J Hosp Pharm 1983;40:1957–1960.Google ScholarPubMed
Dowling, H. Fighting Infection, Conquests of the Twentieth Century. Cambridge, MA: Harvard University Press; 1977:106.CrossRefGoogle Scholar
Marr, JJ, Moffet, HL, Kunin, CM. Guidelines for improving the use of antimicrobial agents in hospitals: a statement of the Infectious Diseases Society of America. J Infect Dis 1988;157:869–876.CrossRefGoogle ScholarPubMed
White, AC, Atmar, RL, Wilson, J, Cate, TR, Stager, CE, Greenberg, SB. Effects of requiring prior authorization for selected antimicrobials: expenditures, susceptibilities, and clinical outcomes. Clin Infect Dis 1997;25:230–239.CrossRefGoogle ScholarPubMed
Dunagan, WB, Medoff, G. Formulary control of antimicrobial usage. what price freedom? Diagn Microbiol Infect Dis 1993;16:265–274.CrossRefGoogle ScholarPubMed
Frank, MO, Batteiger, BE, Sorensen, SJ, et al. Decrease in expenditures and selected nosocomial infections following implementation of an antimicrobial-prescribing improvement program. Clin Perform Qual Health Care 1997;5:180–188.Google ScholarPubMed
Fishman, N. Antimicrobial stewardship. Am J Infect Control 2006;34:S55–S63.CrossRefGoogle ScholarPubMed