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Effects of Chlorhexidine Oral Decontamination on Respiratory Colonization during Mechanical Ventilation in Intensive Care Unit Patients

Published online by Cambridge University Press:  02 January 2015

Douwe F. Postma ,
Sanjay U. C. Sankatsing ,
Steven F. T. Thijsen  and
Henrik Endeman
Douwe F. Postma*
Affiliation:
Department of Internal Medicine, Diakonessenhuis, Utrecht, the Netherlands
Sanjay U. C. Sankatsing
Affiliation:
Department of Internal Medicine, Diakonessenhuis, Utrecht, the Netherlands
Steven F. T. Thijsen
Affiliation:
Department of Medical Microbiology, Diakonessenhuis, Utrecht, the Netherlands
Henrik Endeman
Affiliation:
Department of Intensive Care Medicine, Onze Lieve Vrouwe Gasthuis, Amsterdam, the Netherlands
*
University Medical Centre Utrecht, Julius Center for Health Sciences, PO Box 85500, 3508 GA, Utrecht, the Netherlands ([email protected])
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Abstract

We conducted a retrospective cohort study to assess respiratory colonization before and after the use of chlorhexidine oral decontamination among a cohort of intensive care unit patients who received mechanical ventilation. We observed a decrease in the prevalence of Enterobacteriaceae and an increase in the incidence of fungal colonization. Chlorhexidine oral decontamination might have a differential effect on respiratory colonization.

Type
Concise Communication
Information
Infection Control & Hospital Epidemiology , Volume 33 , Issue 5 , May 2012 , pp. 527 - 530
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2012

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References

1.Safdar, N, Dezfulian, C, Collard, HR, Saint, S. Clinical and economic consequences of ventilator-associated pneumonia: a systematic review. Crit Care Med 2005;33(10):2184–2193.CrossRefGoogle ScholarPubMed
2. Garrouste-Org, Chevret, S, Arlet, G, et al. Oropharyngeal or gastric colonization and nosocomial pneumonia in adult intensive care unit patients: a prospective study based on genomic DNA analysis. Am J Respir Crit Care Med 1997;156(5):1647–1655.Google Scholar
3.de Smet, AM, Kluytmans, JA, Cooper, BS, et al. Decontamination of the digestive tract and oropharynx in ICU patients. N Engl J Med 2009;360(1):20–31.CrossRefGoogle ScholarPubMed
4.de la Cal, MA, Cerda, E, Garcia-Hierro, P, et al. Pneumonia in patients with severe burns: a classification according to the concept of the carrier state. Chest 2001;119(4):1160–1165.CrossRefGoogle Scholar
5.Koeman, M, van der Ven, AJ, Hak, E, et al. Oral decontamination with Chlorhexidine reduces the incidence of ventilator-associated pneumonia. Am JRespir Crit Care Med 2006;173(12):1348–1355.CrossRefGoogle ScholarPubMed
6.Tantipong, H, Morkchareonpong, C, Jaiyindee, S, Thamlikitkul, V. Randomized controlled trial and meta-analysis of oral decontamination with 2% Chlorhexidine solution for the prevention of ventilator-associated pneumonia. Infect Control Hosp Epidemiol 2008;29(2):131–136.CrossRefGoogle ScholarPubMed
7.Bellissimo-Rodrigues, F, Bellissimo-Rodrigues, WT, Viana, JM, et al. Effectiveness of oral rinse with Chlorhexidine in preventing nosocomial respiratory tract infections among intensive care unit patients. Infect Control Hosp Epidemiol 2009;30(10): 952–958.CrossRefGoogle ScholarPubMed
8.Scannapieco, FA, Yu, J, Raghavendran, K, et al. A randomized trial of Chlorhexidine gluconate on oral bacterial pathogens in mechanically ventilated patients. Crit Care 2009;13(4):R117.CrossRefGoogle ScholarPubMed
9.Lim, KS, Kam, PC. Chlorhexidine: pharmacology and clinical applications. Anaesth Intensive Care 2008;36(4):502–512.CrossRefGoogle ScholarPubMed
10.Reichel, M, Heisig, P, Kampf, G. Pitfalls in efficacy testing-how important is the validation of neutralization of Chlorhexidine digluconate? Ann Clin Microbiol Antimicrob 2008;7:20.CrossRefGoogle ScholarPubMed