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Cytomegalovirus

Published online by Cambridge University Press:  02 January 2015

John T. Sinnott IV  and
Margarita R. Cancio
John T. Sinnott IV*
Affiliation:
Division of Infectious and Tropical Diseases, University of South Florida College of Medicine, Tampa, Florida
Margarita R. Cancio
Affiliation:
Division of Infectious and Tropical Diseases, University of South Florida College of Medicine, Tampa, Florida
*
The Tampa General Hospital, Davis Island, PO Box 1289, Tampa, FL 33601
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Extract

Cytomegalovirus (CMV) has emerged as an important cause of human illness. Infection with this common virus can result in asymptomatic infection, an acute “mononucleosis-like” illness, or congenital disease. It is capable of persisting in a latent state and reactivating at a later date. It can be transmitted by blood transfusion, organ transplantation, oral or genital contact, intrauterine infection, perinatal infection and perhaps casually by children in day care centers.

Historically, the first reports described “protozoan-like” cells in the organs of a fetus and a stillborn in 1904. In 1932, Farber reported the presence of inclusions in the nucleus and cytoplasm of cells in infants dying of various causes and coined the term cytomegalic inclusion disease. The urine was initially cultured in 1953 by Smith, and the subsequent development of serologic methods of diagnosis made its broad spectrum of disease more fully appreciated.

Type
Special Sections
Information
Infection Control & Hospital Epidemiology , Volume 8 , Issue 2 , February 1987 , pp. 79 - 82
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1987

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References

1.Jesionek, A, Kiolemenoglou, : Ueber einen Befund von protozoen - antigen gebilden in den Organen eines herditar-luetischen foetus. Munich Med Wochenschr 1904; 51:1905–1907.Google Scholar
2.Ribbert, H: Ueber protozoanartige Zellen in der Niere eines syphilitischen Neugeboreneun und in der Parotis von Kindern. Zbl allg Path pathol Anat 1902; 15:945.Google Scholar
3.Farber, S, Wolbach, SB: Intranuclear and cytoplasma inclusions (“protozoan-1:16 bodies) in the salivary glands and other organs of infants. Am J Pathol 1932; 8:123.Google Scholar
4.Smith, MZ: Propagation in tissue cultures of a cytopathogenic virus from human salivary gland virus (SGV) disease. Proc Soc Exp Biol Med 1956; 92:424.CrossRefGoogle ScholarPubMed
5.Colin, JM: Latent infection and the elusive cytomegalovirus. Rev Infect Dis 1983; 5(2):205–215.Google Scholar
6.Laurence, J: CMV infections in AIDS patients. Infect Surg 1986; 5(10):603–610.Google Scholar
7.Giraldo, G, Beth, E: The involvement of cytomegalovirus in acquired immune deficiency syndrome and Kaposi's sarcoma. Prog Allergy 1986; 37:319–331.Google Scholar
8.Rapp, F: Cytomegalovirus and carcinogenesis. J Natl Cancer Inst 1984; 72(4):783–787.Google ScholarPubMed
9.Lamberson, HV: Cytomegalovirus (CMV): The agent, its pathogenesis, and its epidemiology. Infect Immun Bid Trans 1985; 149–173.Google ScholarPubMed
10.Schuster, V, Matz, B, Wiegand, H, et al: Detection of human cytomegalovirus in urine by DNA-DNA and RNA-DNA hybridization. J Infect Dis 1986; 154(2):309–314.Google Scholar
11.Spector, SA, Spector, DH: The use of DNA probes in studies of human cytomegalovirus. Clin Chem 1985; 31(9):1514–1520.Google Scholar
12.Booth, JC, Hannington, G, Bakin, TMF, et al: Comparison of enzyme-linked immunosorbent assay, radioimmunoassay, complement fixations, anticomplement immunofluorescence and passive hemaglutination techniques for detecting cytomegalovirus. J Clin Pathol 1982; 135:1345.Google Scholar
13.Pass, RF, Griffiths, PD: Antibody response to cytomegalovirus after renal transplantation: Comparison of patients with primary and recurrent infections. J Infect Dis 1983; 147(1):40–46.CrossRefGoogle ScholarPubMed
14.Glen, J: Cytomegalovirus infections following renal transplantation. Rev Infect Dis 1981; 3(6):1131–1178.Google Scholar
15.Krechu, U: Complement fixing antibodies against cytomegalovirus in different parts of the world. Bull WHO 1973; 49:103–106.Google Scholar
16.Stagno, S, Reynolds, D, Tsiantos, A, et al: Comparative serial virologic and serologic studies of symptomatic and subclinical congenitally and natally acquired cytomegalovirus infection. J Infect Dis 1975; 132:568.Google Scholar
17.Stagno, S, Reynolds, D, Tsiantos, A, et al: Cervical cytomegalovirus excretion in pregnant and nonpregnant women: Suppression in early gestation. J Infect Dis 1975; 131:522–527.Google Scholar
18.Stagno, S, Pass, RF, Dworsky, ME, et al: Congenital cytomegalovirus infection. The relative importance of primary and maternal infection. N Engl J Med 1982; 306:945–949.Google Scholar
19.Griffiths, PD, Stagno, S, Pass, RF, et al: Congenital cytomegalovirus infection: Diagnostic and prognostic significance of detection of specific immunoglobulin M antibodies in cord serum. Pediatrics 1982; 69(5):544–549.Google Scholar
20.Colin, JM, Rousseau, WE, Stewart, JA, et al: Spontaneous cytomegalovirus mononucleosis. Clinical and laboratory observations in nine cases. Ann Intern Med 1973; 79:153–160.Google Scholar
21.Suwansirikul, S, Rao, N, Dowling, JN, et al: Primary and secondary cytomegalovirus infection. Arch Intern Med 1977; 137:1026–1029.Google Scholar
22.Gadler, H, Tillegard, A, Groth, CG: Studies of cytomegalovirus infection in renal allograft recipients. Scand J Infect Dis 1982; 14:81–87.Google Scholar
23.Ho, M, Suwansirikul, S, Dowling, JN, et al: The transplanted kidney as a source: of cytomegalovirus infection. N Engl J Med 1975; 293:1109–1112.CrossRefGoogle ScholarPubMed
24.Tolkcoff-Rubin, NE, Rubin, RH, Keller, EE, et al: Cytomegalovirus infection in dialysis patients and personnel. Ann Intern Med 1978; 89:625–628.Google Scholar
25.Hirsch, MS, Felsenstein, D: Cytomegalovirus-induced immunosuppression. Ann NY Acad Sci 1984; 437:8–15.Google Scholar
26.Abdallah, PS, Mark, JBD, Merigan, TC, et al: Diagnosis of cytomegalovirus pneumonia in compromised hosts. Am J Med 1976; 61:326–332.CrossRefGoogle ScholarPubMed
27.Mintz, L, Drew, WL, Miner, RC, et al: Cytomegalovirus infections in homosexual men. An epidemiologic study. Ann Intern Med> 1983; 326–329.CrossRef+1983;+326–329.>Google Scholar
28.Masur, H, Lane, HC, Palestine, A, et al: Effect of 9-(l,3,-dihydroxy-2-propoxymethyl)guanine on serious cytomegalovirus disease in eight immunosuppressed homosexual men. Ann Intern Med 1986; 104:41–44.CrossRefGoogle Scholar
29.Koretz, SH, Buhles, WC, Brewin, A, et al: Treatment of serious cytomegalovirus infections with 9-(1,3-dihydroxy-2-propoxymethyl) guanine in patients with AIDS and other immunodeficiencies. N Engl J Med 1986; 314:801–805.Google Scholar
30.Meyers, JD, Leszczynski, J, Zaia, JA, et al: Prevention of cytomegalovirus infection by cytomegalovirus immunoglobulin after marrow transplantation. Ann Intern Med 1983; 98:442–446.Google Scholar
31.Dreikon, K, Doerr, HW, Geursen, RG, et al: Cytomegalovirus (CMV) infections in renal transplant recipients. Preliminary results of prophylaxis by an intramuscular human hyperimmune CMV IgG. Scand J Urol Nephrol[Suppl] 1985; 92:15–21.Google Scholar