Hostname: page-component-586b7cd67f-2plfb Total loading time: 0 Render date: 2024-11-28T15:24:59.693Z Has data issue: false hasContentIssue false

Contamination of the Hospital Environment From Potential Clostridium difficile Excretors Without Active Infection

Published online by Cambridge University Press:  10 April 2015

Jason S. Biswas
Affiliation:
Centre for Clinical Infection and Diagnostics Research, King’s College, London and Guy’s & St Thomas’ NHS Foundation Trust, United Kingdom
Amita Patel
Affiliation:
Centre for Clinical Infection and Diagnostics Research, King’s College, London and Guy’s & St Thomas’ NHS Foundation Trust, United Kingdom
Jonathan A. Otter
Affiliation:
Centre for Clinical Infection and Diagnostics Research, King’s College, London and Guy’s & St Thomas’ NHS Foundation Trust, United Kingdom
Esther van Kleef
Affiliation:
London School of Hygiene and Tropical Medicine, United Kingdom Public Health England, United Kingdom.
Simon D. Goldenberg*
Affiliation:
Centre for Clinical Infection and Diagnostics Research, King’s College, London and Guy’s & St Thomas’ NHS Foundation Trust, United Kingdom
*
Address correspondence to Simon D. Goldenberg, MD, DipHIC, FRCPath, Centre for Clinical Infection and Diagnostics Research, King’s College, London and Guy’s & St Thomas’ NHS Foundation Trust, Westminster Bridge Road, London SE1 7EH, United Kingdom ([email protected]).

Abstract

Clostridium difficile was recovered from 33 (34%) of 98 rooms of patients who were excretors compared with 36 (49%) of 73 rooms of patients with active infection. Not all laboratory algorithms can distinguish between these 2 groups, yet both may be a significant source for ongoing transmission.

Infect Control Hosp Epidemiol 2015;36(8): 975–977

Type
Concise Communications
Copyright
© 2015 by The Society for Healthcare Epidemiology of America. All rights reserved 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Planche, TD, Davies, KA, Coen, PG, et al. Differences in outcome according to Clostridium difficile testing method: a prospective multicentre diagnostic validation study of C. difficile infection. Lancet Infect Dis 2013;13:936945.CrossRefGoogle Scholar
2. Goldenberg, SD. Laboratory diagnosis of Clostridium difficile . Lancet Infect Dis 2013;13:909911.Google Scholar
3. Eyre, DW, Griffiths, D, Vaughan, A, et al. Asymptomatic Clostridium difficile colonisation and onward transmission. PLOS One 2013;8:e78445.Google Scholar
4. Galdys, AL, Nelson, JS, Shutt, KA, et al. Prevalence and duration of asymptomatic Clostridium difficile carriage among healthy subjects in Pittsburgh, Pennsylvania. J Clin Microbiol 2014;52:24062409.Google Scholar
5. Alasmari, F, Seiler, SM, Hink, T, Burnham, CA, Dubberke, ER. Prevalence and risk factors for asymptomatic Clostridium difficile carriage. Clin Infect Dis 2014;59:216222.CrossRefGoogle ScholarPubMed
6. Guerrero, DM, Chou, C, Jury, LA, Nerandzic, MM, Cadnum, JC, Donskey, CJ. Clinical and infection control implications of Clostridium difficile infection with negative enzyme immunoassay for toxin. Clin Infect Dis 2011;53:287290.Google Scholar
7. Kamboj, M, Babady, NE, Marsh, JW, et al. Estimating risk of C. difficile transmission from PCR positive but cytotoxin negative cases. PLOS One 2014;9:e88262.Google Scholar
8. Goldenberg, SD, Patel, A, Tucker, D, French, GL. Lack of enhanced effect of a chlorine dioxide-based cleaning regimen on environmental contamination with Clostridium difficile spores. J Hosp Infect 2012;82:6467.CrossRefGoogle ScholarPubMed
9. Otter, JA, Yezli, S, French, GL. The role played by contaminated surfaces in the transmission of nosocomial pathogens. Infect Control Hosp Epidemiol 2011;32:687699.Google Scholar
10. Mayfield, JL, Leet, T, Miller, J, Mundy, LM. Environmental control to reduce transmission of Clostridium difficile . Clin Infect Dis 2000;31:9951000.Google Scholar
11. Shaughnessy, MK, Micielli, RL, Depestel, DD, et al. Evaluation of hospital room assignment and acquisition of Clostridium difficile infection. Infect Control Hosp Epidemiol 2011;32:201206.CrossRefGoogle ScholarPubMed