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Comparison of a Semipermeable Dressing Bonded to an Absorbent Pad and a Semipermeable Dressing Over a Separate Gauze Pad for Containment of Vaccinia Virus at the Vaccination Site

Published online by Cambridge University Press:  02 January 2015

Michael R. Savona ,
Wilfred P. Dela Cruz ,
Jennifer A. Thornton  and
Patrick J. Danaher
Michael R. Savona
Affiliation:
Division of Hematology and Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor
Wilfred P. Dela Cruz
Affiliation:
Clinical Investigation Facility, David Grant Unites States Air Force (USAF) Medical Center, Travis Air Force Base (AFB), California
Jennifer A. Thornton
Affiliation:
Clinical Investigation Facility, David Grant Unites States Air Force (USAF) Medical Center, Travis Air Force Base (AFB), California
Patrick J. Danaher*
Affiliation:
Department of Infectious Diseases, Eglin USAF Regional Hospital, Eglin AFB, Florida
*
Infectious Diseases, 96 MDG/96 MDOS/SGOMI, 307 Boatner Road, Suite 114, Eglin AFB, FL 32542-1282 ([email protected])
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Abstract

Objective.

To compare the ability of 2 types of dressings to contain vaccinia virus after smallpox vaccination.

Design.

Prospective, nonrandomized trial.

Setting.

The smallpox vaccination clinic in a medium-sized military hospital.

Participants.

Ninety-seven active-duty military members who received smallpox vaccination in accordance with US Department of Defense and Centers for Disease Control and Prevention guidelines.

Methods.

The first 40 participants enrolled were instructed to cover their vaccination sites with a semipermeable membrane placed over a separate gauze pad, and the subsequent 57 participants were given a semipermeable membrane bonded to an absorbent pad. Swab samples of the external surface of the dressing were collected 7 and 21 days after vaccination. Real-time quantitative polymerase chain reaction was used to detect vaccinia DNA in the samples.

Results.

The rate of vaccinia DNA detection was significantly higher for samples obtained from vaccinees who were using the separate gauze and semipermeable membrane, compared with the vacinees who were using the gauze-impregnated semipermeable membrane (22% vs 2.2%; P = .008; odds ratio, 12.3 [95% confidence interval, 1.4-567.4]).

Conclusion.

A gauze-impregnated semipermeable membrane more effectively reduced viral passage to the external surface of the dressing than did a semipermeable membrane placed over a separate gauze pad. Routine use of such dressings following smallpox vaccination might reduce the incidence of autoinoculation and secondary transmission.

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 28 , Issue 12 , December 2007 , pp. 1339 - 1343
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2007

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