Hostname: page-component-78c5997874-8bhkd Total loading time: 0 Render date: 2024-11-02T20:18:27.595Z Has data issue: false hasContentIssue false

Changing Epidemiology of Community-Onset Methicillin-Resistant Staphylococcus aureus Bacteremia

Published online by Cambridge University Press:  02 January 2015

Leonard B. Johnson*
Affiliation:
St. John Hospital and Medical Center, Wayne State University, Detroit, Michigan
Arti Bhan
Affiliation:
St. John Hospital and Medical Center, Wayne State University, Detroit, Michigan
Joan Pawlak
Affiliation:
St. John Hospital and Medical Center, Wayne State University, Detroit, Michigan
Odette Manzor
Affiliation:
St. John Hospital and Medical Center, Wayne State University, Detroit, Michigan
Louis D. Saravolatz
Affiliation:
St. John Hospital and Medical Center, Wayne State University, Detroit, Michigan
*
St. John Hospital and Medical Center, 22101 Moross Road, Detroit, MI 48236

Abstract

Objectives:

To review cases of community-onset Staphylococcus aureus bacteremia and to evaluate whether the risk factors and epidemiology of methicillin-resistant S. aureus (MRSA) bacteremia have changed from early reports.

Design:

Retrospective case-comparison study of community-onset MRSA (n - 26) and methicillin-susceptible S. aureus (MSSA) (n = 26) bacteremias at our institution.

Setting:

A 600-bed urban academic medical center.

Patients:

Twenty-six patients with community-onset MRSA bacteremia were compared with 26 patients with community-onset MSSA bacteremia. Molecular analysis was performed on S. aureus isolates from the 26 MRSA cases as well as from 13 cases of community-onset S. aureus bacteremia from 1980 and 9 cases of nosocomial S. aureus bacteremia from 2001.

Results:

The two groups were similar except that patients with MRSA bacteremia were more likely to have presented from a long-term-care facility (26.9% vs 4%; P = .05) and to have had multiple admissions within the preceding year (46% vs 15%; P = .03). Clamped homogeneous electric fields analysis of MRSA isolates from 1982 revealed predominantly that one clone was the epidemic strain, whereas there were 14 unique strains among current community-onset isolates. Among current nosocomial isolates, 3 patterns were identified, all of which were present in the community-onset cases.

Conclusions:

Previously described risk factors for MRSA acquisition may not be helpful in predicting disease due to the polyclonal spread of MRSA in the community. Unlike early outbreaks of MRSA in patients presenting from the community, current acquisition appears to be polyclonal and is usually related to contact with the healthcare system.

Type
Orginal Articles
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2003

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Colley, EW, McNicol, MW, Bracken, PM. Methicillin-resistant staphylococci in a general hospital. Lancet 1965;1:595597.CrossRefGoogle ScholarPubMed
2.Barrett, FF, McGehee, RF Jr, Finland, M. Methicillin-resistant Staphylococcus aureus at Boston City Hospital. N Engl J Med 1968;27:441448.CrossRefGoogle Scholar
3.OToole, RD, Drew, WL, Dahlgren, BJ, Beatty, AN. An outbreak of methicillin-resistant Staphylococcus aureus infections: observations in a hospital and nursing home. JAMA 1970;213:257263.CrossRefGoogle Scholar
4.Saravolatz, LD, Markowitz, N, Arking, L, Pohlod, D, Fisher, E. Methicillin-resistant Staphylococcus aureus: epidemiologic observations during a community-acquired outbreak. Ann Intern Med 1982;96:1116.CrossRefGoogle ScholarPubMed
5.Saravolatz, LD, Pohlod, DJ, Arking, LM. Community-acquired methicillin-resistant Staphylococcus aureus infections: a new source of nosocomial outbreaks. Ann Intern Med 1982;97:325329.CrossRefGoogle ScholarPubMed
6.Warshawsky, B, Hussain, Z, Gregson, DB, et al.Hospital- and community-based surveillance of methicillin-resistant Staphylococcus aureus (MRSA): previous hospitalization is the major risk factor. Infect Control Hosp Epidemiol 2000;21:724727.Google Scholar
7.Craven, DE, Rixinger, AI, Goularte, TA, McCabe, WR. Methicillin-resistant Staphylococcus aureus bacteremia linked to intravenous drug abusers using a “shooting gallery.” Am J Med 1986;80:770776.Google Scholar
8.Berman, D, Schaefler, S, Simberkoff, MS, Rahal, JJ. Staphylococcus aureus colonization in intravenous drug abusers, dialysis patients, and diabetics. J Infect Dis 1987;155:829831.Google Scholar
9.Steinberg, JP, Clark, CC, Hackmann, BO. Nosocomial and community-acquired Staphylococcus aureus bacteremias from 1980 to 1993: impact of intravascular devices and methicillin resistance. Clin Infect Dis 1996;23:255259.Google Scholar
10.Berman, DS, Eisner, W, Kreiswirth, B. Community-acquired methicillin-resistant Staphylococcus aureus infection. N Engl J Med 1993;329:1896.Google Scholar
11.Herold, BC, Immergluck, LC, Maranan, MC, et al.Community-acquired methicillin-resistant Staphylococcus aureus in children with no identified predisposing risk. JAMA 1998;279:593598.Google Scholar
12.Gorak, EJ, Yamada, SM, Brown, JD. Community-acquired methicillinresistant Staphylococcus aureus in hospitalized adults and children without known risk factors. Clin Infect Dis 1999;29:797800.Google Scholar
13.Centers for Disease Control and Prevention. Four pediatric deaths from community-acquired MRSA: Minnesota and North Dakota, 1997-1999. MMWR 1999;48:707710.Google Scholar
14.Morin, CA, Hadler, JL. Population-based incidence and characteristics of community-onset Staphylococcus aureus infections with bacteremia in 4 metropolitan Connecticut areas, 1998. J Infect Dis 2001;184:10291034.Google Scholar
15.Frank, AL, Marcinak, JF, Mangat, PD, Schreckenberger, PC. Increase in community-acquired methicillin-resistant Staphylococcus aureus in children. Clin Infect Dis 1999;29:935936.Google Scholar
16.Moreno, F, Crisp, C, Jorgensen, JH, Patterson, JE. Methicillin-resistant Staphylococcus aureus as a community organism. Clin Infect Dis 1995;21:13081312.CrossRefGoogle ScholarPubMed
17.Groom, AV, Wolsey, DH, Naimi, TS, et al.Community-acquired methicillin-resistant Staphylococcus aureus in a rural American Indian community. JAMA 2001;286:12011205.CrossRefGoogle Scholar
18.Shopsin, B, Mathema, B, Martinez, J, et al.Prevalence of methicillin-resistant and methicillin-susceptible Staphylococcus aureus in the community. J Infect Dis 2000;182:359362.CrossRefGoogle ScholarPubMed
19.Charlebois, ED, Bangsberg, DR, Moss, NJ, et al.Population-based community prevalence of methicillin-resistant Staphylococcus aureus in the urban poor of San Francisco. Clin Infect Dis 2002;34:425433.Google Scholar
20.Layton, MC, Hierholzer, W Jr, Patterson, JE. The evolving epidemiology of methicillin-resistant Staphylococcus aureus at a university hospital. Infect Control Hosp Epidemiol 1995;16:1217.Google Scholar