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Bacteremia and Mortality with Urinary Catheter–Associated Bacteriuria

Part of: BARRY FARR AWARD RECIPIENTS

Published online by Cambridge University Press:  02 January 2015

Quratulain F. Kizilbash ,
Nancy J. Petersen ,
Guoqing J. Chen ,
Aanand D. Naik  and
Barbara W. Trautner
Quratulain F. Kizilbash
Affiliation:
Section of Infectious Diseases, Department of Medicine, Baylor College of Medicine, Houston, Texas Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas
Nancy J. Petersen
Affiliation:
Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas Houston Veterans Affairs Health Services Research and Development Center of Excellence, Houston, Texas Section of Health Services Research, Department of Medicine, Baylor College of Medicine, Houston, Texas
Guoqing J. Chen
Affiliation:
Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas Houston Veterans Affairs Health Services Research and Development Center of Excellence, Houston, Texas Section of Health Services Research, Department of Medicine, Baylor College of Medicine, Houston, Texas
Aanand D. Naik
Affiliation:
Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas Houston Veterans Affairs Health Services Research and Development Center of Excellence, Houston, Texas Section of Geriatrics, Department of Medicine, Baylor College of Medicine, Houston, Texas
Barbara W. Trautner*
Affiliation:
Section of Infectious Diseases, Department of Medicine, Baylor College of Medicine, Houston, Texas Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas Houston Veterans Affairs Health Services Research and Development Center of Excellence, Houston, Texas
*
2002 Holcombe Boulevard, Houston, TX 77030 ([email protected]) or Aanand Naik, MD, MEDVAMC (152), 2002 Holcombe Boulevard, Houston, TX 77030 ([email protected])
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Abstract

Objective.

Although catheter-associated urinary tract infection (CAUTI) and catheter-associated asymptomatic bacteriuria (CAABU) are clinically distinct conditions, most literature describing the risks of bacteriuria does not distinguish between them. We studied the relationship between catheter-associated bacteriuria and bacteremia from a urinary source in CAUTI relative to that in CAABU. Second, we investigated whether the presence or absence of urinary symptoms in catheterized patients with bacteriuria was associated with bacteremia from any source or mortality. Finally, we explored the effect of antimicrobial treatment of bacteriuria on subsequent bacteremia from any source and mortality.

Design.

We performed a retrospective cohort study with 30 days of follow-up after an initial positive urine culture. CAUTI and CAABU were defined by Infectious Diseases Society of America guidelines.

Setting.

A large tertiary care facility.

Patients.

All inpatients with a urinary catheter (external or indwelling) and a positive urine culture between October 2010 and June 2011.

Results.

We captured 444 episodes of catheter-associated bacteriuria in 308 patients; 128 (41.6%) patients had CAUTI, and 180 (58.4%) had CAABU. Three episodes of bacteriuria were followed by bacteremia from a urinary source (0.7%). CAUTI, rather than CAABU, was associated with bacteremia from any source, but neither CAUTI nor CAABU predicted subsequent mortality. Use of antimicrobial agents to treat bacteriuria was not associated with either bacteremia from any source or mortality.

Conclusions.

Bacteremia from a urinary source was infrequent, and there was no evidence of an association of mortality with symptomatic versus asymptomatic bacteriuria in this population. Antibiotic treatment of bacteriuria did not affect outcomes.

Type
Original Article
Information
Infection Control & Hospital Epidemiology , Volume 34 , Issue 11 , November 2013 , pp. 1153 - 1159
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2013

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