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Attributable mortality due to fluoroquinolone and extended-spectrum cephalosporin resistance in hospital-onset Escherichia coli and Klebsiella spp bacteremia: A matched cohort study in 129 Veterans Health Administration medical centers

Published online by Cambridge University Press:  14 June 2019

Hiroyuki Suzuki Open the ORCID record for Hiroyuki Suzuki [Opens in a new window] ,
Eli N. Perencevich ,
Daniel J. Livorsi ,
Bruce Alexander ,
Brice F. Beck ,
Kelly K. Richardson  and
Michihiko Goto
Hiroyuki Suzuki*
Affiliation:
Center for Comprehensive Access & Delivery Research & Evaluation (CADRE), Iowa City Veterans Affairs Health Care System, Iowa City, Iowa Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa
Eli N. Perencevich
Affiliation:
Center for Comprehensive Access & Delivery Research & Evaluation (CADRE), Iowa City Veterans Affairs Health Care System, Iowa City, Iowa Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa
Daniel J. Livorsi
Affiliation:
Center for Comprehensive Access & Delivery Research & Evaluation (CADRE), Iowa City Veterans Affairs Health Care System, Iowa City, Iowa Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa
Bruce Alexander
Affiliation:
Center for Comprehensive Access & Delivery Research & Evaluation (CADRE), Iowa City Veterans Affairs Health Care System, Iowa City, Iowa
Brice F. Beck
Affiliation:
Center for Comprehensive Access & Delivery Research & Evaluation (CADRE), Iowa City Veterans Affairs Health Care System, Iowa City, Iowa
Kelly K. Richardson
Affiliation:
Center for Comprehensive Access & Delivery Research & Evaluation (CADRE), Iowa City Veterans Affairs Health Care System, Iowa City, Iowa
Michihiko Goto*
Affiliation:
Center for Comprehensive Access & Delivery Research & Evaluation (CADRE), Iowa City Veterans Affairs Health Care System, Iowa City, Iowa Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa
*
Author for correspondence: Hiroyuki Suzuki, Center for Comprehensive Access & Delivery Research & Evaluation (CADRE)/Iowa City Veterans Affairs Health Care System, 601 Highway 6 West, Iowa City, IA 52246, Phone: 319-887-4938 Fax: 319-887-4932. Email: [email protected]. Or Michihiko Goto, Email: [email protected].
Author for correspondence: Hiroyuki Suzuki, Center for Comprehensive Access & Delivery Research & Evaluation (CADRE)/Iowa City Veterans Affairs Health Care System, 601 Highway 6 West, Iowa City, IA 52246, Phone: 319-887-4938 Fax: 319-887-4932. Email: [email protected]. Or Michihiko Goto, Email: [email protected].
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Abstract

In this cohort of Escherichia coli and Klebsiella spp hospital-onset bacteremia, isolated fluoroquinolone resistance had a larger relative impact on mortality than other phenotypic resistance patterns. This finding may support stewardship efforts targeting unnecessary fluoroquinolone use and increased attention from infection prevention and control departments.

Type
Concise Communication
Information
Infection Control & Hospital Epidemiology , Volume 40 , Issue 8 , August 2019 , pp. 928 - 931
Copyright
© 2019 by The Society for Healthcare Epidemiology of America. All rights reserved. 

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References

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