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Attributable mortality due to fluoroquinolone and extended-spectrum cephalosporin resistance in hospital-onset Escherichia coli and Klebsiella spp bacteremia: A matched cohort study in 129 Veterans Health Administration medical centers

Published online by Cambridge University Press:  14 June 2019

Hiroyuki Suzuki Open the ORCID record for Hiroyuki Suzuki [Opens in a new window] ,
Eli N. Perencevich ,
Daniel J. Livorsi ,
Bruce Alexander ,
Brice F. Beck ,
Kelly K. Richardson  and
Michihiko Goto
Hiroyuki Suzuki*
Affiliation:
Center for Comprehensive Access & Delivery Research & Evaluation (CADRE), Iowa City Veterans Affairs Health Care System, Iowa City, Iowa Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa
Eli N. Perencevich
Affiliation:
Center for Comprehensive Access & Delivery Research & Evaluation (CADRE), Iowa City Veterans Affairs Health Care System, Iowa City, Iowa Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa
Daniel J. Livorsi
Affiliation:
Center for Comprehensive Access & Delivery Research & Evaluation (CADRE), Iowa City Veterans Affairs Health Care System, Iowa City, Iowa Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa
Bruce Alexander
Affiliation:
Center for Comprehensive Access & Delivery Research & Evaluation (CADRE), Iowa City Veterans Affairs Health Care System, Iowa City, Iowa
Brice F. Beck
Affiliation:
Center for Comprehensive Access & Delivery Research & Evaluation (CADRE), Iowa City Veterans Affairs Health Care System, Iowa City, Iowa
Kelly K. Richardson
Affiliation:
Center for Comprehensive Access & Delivery Research & Evaluation (CADRE), Iowa City Veterans Affairs Health Care System, Iowa City, Iowa
Michihiko Goto*
Affiliation:
Center for Comprehensive Access & Delivery Research & Evaluation (CADRE), Iowa City Veterans Affairs Health Care System, Iowa City, Iowa Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa
*
Author for correspondence: Hiroyuki Suzuki, Center for Comprehensive Access & Delivery Research & Evaluation (CADRE)/Iowa City Veterans Affairs Health Care System, 601 Highway 6 West, Iowa City, IA 52246, Phone: 319-887-4938 Fax: 319-887-4932. Email: [email protected]. Or Michihiko Goto, Email: [email protected].
Author for correspondence: Hiroyuki Suzuki, Center for Comprehensive Access & Delivery Research & Evaluation (CADRE)/Iowa City Veterans Affairs Health Care System, 601 Highway 6 West, Iowa City, IA 52246, Phone: 319-887-4938 Fax: 319-887-4932. Email: [email protected]. Or Michihiko Goto, Email: [email protected].
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Abstract

In this cohort of Escherichia coli and Klebsiella spp hospital-onset bacteremia, isolated fluoroquinolone resistance had a larger relative impact on mortality than other phenotypic resistance patterns. This finding may support stewardship efforts targeting unnecessary fluoroquinolone use and increased attention from infection prevention and control departments.

Type
Concise Communication
Information
Infection Control & Hospital Epidemiology , Volume 40 , Issue 8 , August 2019 , pp. 928 - 931
Copyright
© 2019 by The Society for Healthcare Epidemiology of America. All rights reserved. 

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References

Rottier, WC, Ammerlaan, HS, Bonten, MJ. Effects of confounders and intermediates on the association of bacteraemia caused by extended-spectrum beta-lactamase-producing Enterobacteriaceae and patient outcome: a meta-analysis. J Antimicrob Chemother 2012;67:1311–1320.CrossRefGoogle ScholarPubMed
Lautenbach, E, Metlay, JP, Bilker, WB, Edelstein, PH, Fishman, NO. Association between fluoroquinolone resistance and mortality in Escherichia coli and Klebsiella pneumoniae infections: the role of inadequate empirical antimicrobial therapy. Clin Infect Dis 2005;41:923–929.Google ScholarPubMed
Kaye, KS, Engemann, JJ, Mozaffari, E, Carmeli, Y. Reference group choice and antibiotic resistance outcomes. Emerg Infect Dis 2004;10:1125–1128.CrossRefGoogle ScholarPubMed
Harris, AD, Karchmer, TB, Carmeli, Y, Samore, MH. Methodological principles of case-control studies that analyzed risk factors for antibiotic resistance: a systematic review. Clin Infect Dis 2001;32:1055–1061.CrossRefGoogle ScholarPubMed
Deyo, RA, Cherkin, DC, Ciol, MA. Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol 1992;45:613–619.CrossRefGoogle ScholarPubMed
Zou, G. A modified poisson regression approach to prospective studies with binary data. Am J Epidemiol 2004;159:702–706.CrossRefGoogle ScholarPubMed
Levin, ML. The occurrence of lung cancer in man. Acta Unio Int Contra Cancrum 1953;9:531–541.Google ScholarPubMed
Nilholm, H, Holmstrand, L, Ahl, J, et al. An audit-based, infectious disease specialist-guided antimicrobial stewardship program profoundly reduced antibiotic use without negatively affecting patient outcomes. Open Forum Infect Dis 2015;2:ofv042.CrossRefGoogle Scholar
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