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Attributable Costs and Length of Stay of an Extended-Spectrum Beta-Lactamase-Producing Klebsiella pneumoniae Outbreak in a Neonatal Intensive Care Unit

Published online by Cambridge University Press:  02 January 2015

Patricia W. Stone ,
Archana Gupta ,
Maureen Loughrey ,
Phyllis Della-Latta ,
Jeannie Cimiotti ,
Elaine Larson ,
David Rubenstein  and
Lisa Saiman
Patricia W. Stone*
Affiliation:
School of Nursing, Columbia University, New York, New York
Archana Gupta
Affiliation:
Department of Pediatrics, Columbia University, New York, New York
Maureen Loughrey
Affiliation:
Children's Hospital of New York, New York-Presbyterian Medical Center, Columbia University, New York, New York
Phyllis Della-Latta
Affiliation:
Department of Pathology, Columbia University, New York, New York
Jeannie Cimiotti
Affiliation:
School of Nursing, Columbia University, New York, New York
Elaine Larson
Affiliation:
School of Nursing, Columbia University, New York, New York Department of Epidemiology, Columbia University, New York, New York
David Rubenstein
Affiliation:
Department of Pediatrics, Columbia University, New York, New York
Lisa Saiman
Affiliation:
Department of Pediatrics, Columbia University, New York, New York Department of Epidemiology, Columbia University, New York, New York
*
617 West 168th Street, New York, NY 10032
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Abstract

Objectives:

To determine the costs of the interventions aimed at controlling the 4-month outbreak and to determine the attributable length of stay (LOS) associated with infection and colonization with extended-spectrum beta-lactamase-producing Klebsiella pneumoniae.

Design:

A retrospective cost analysis was conducted from the hospital perspective. A micro-costing approach was employed. The LOS of four groups of hospitalized patients were compared with each other. National Perinatal Information Center criteria were used to stratify infants for severity of risk. The LOS of each group was compared with that of a national sample of similarly stratified infants.

Setting:

A level III-IV, 45-bed neonatal intensive care unit.

Patients:

Infant groups were infected (n = 8), colonized (n = 14), concurrent cohort (n = 54), and prior cohort (n = 486).

Results:

The cost of the outbreak totaled $341,751. The largest proportion of costs was related to healthcare worker time providing direct patient care (2,489 hours at a cost of $146,331). Infected and colonized neonates had longer LOS than either the concurrent cohort or the prior cohort (P < .001). Compared with the national sample, infected infants had a 48.5-day longer mean LOS (95% confidence interval [CI95], 1.7 to 95.2), whereas the prior cohort's mean LOS was 6 days shorter (CI95, -9.4 to -2.9).

Conclusions:

This study increases the understanding of the burden of these multidrug-resistant organisms. Further research is needed to estimate the societal costs of these infections and the cost-effectiveness of preventive interventions.

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 24 , Issue 8 , August 2003 , pp. 601 - 606
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2003

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