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Assessment of Adverse Events Associated With Antiretroviral Regimens for Postexposure Prophylaxis for Occupational and Nonoccupational Exposures to Prevent Transmission of Human Immunodeficiency Virus

Published online by Cambridge University Press:  02 January 2015

A. Luque ,
S. Hulse ,
D. Wang ,
U. Shahzad ,
E. Tanzman ,
S. Antenozzi  and
B. Smith
A. Luque*
Affiliation:
Infectious Diseases Division, Department of Medicine, Rochester, New York
S. Hulse
Affiliation:
Infectious Diseases Division, Department of Medicine, Rochester, New York
D. Wang
Affiliation:
Department of Biostatistics and Computational Biology, Rochester, New York
U. Shahzad
Affiliation:
Infectious Diseases Division, Department of Medicine, Rochester, New York Department of Infectious Diseases, Allegheny General Hospital, Pittsburgh, Pennsylvania
E. Tanzman
Affiliation:
University of Rochester School of Medicine and Dentistry, University of Rochester Health Service, Rochester, New York
S. Antenozzi
Affiliation:
University of Rochester School of Medicine and Dentistry, University of Rochester Health Service, Rochester, New York
B. Smith
Affiliation:
University of Rochester School of Medicine and Dentistry, University of Rochester Health Service, Rochester, New York
*
University of Rochester Medical Center, Box 689, 601 Elmwood Ave., Rochester, NY 14642 ([email protected])
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Abstract

Objective.

To assess adverse events associated with antiretroviral regimens for human immunodeficiency virus (HIV) postexposure prophylaxis (PEP), with a particular focus on the treatment combination of zidovudine, lamivudine, and tenofovir (ZDV-3TC-TDF).

Methods.

Retrospective chart review for individuals who received HIV PEP for occupational and nonoccupational exposure, and multivariate analyses to identify risk factors for noncompletion of PEP and adverse events associated with PEP.

Setting.

University of Rochester Health Service Occupational Health Program and University of Rochester AIDS Center.

Participants.

Healthcare workers who received HIV PEP for occupational exposure from January 1, 1999, to December 31, 2004, and individuals who received HIV PEP for nonoccupational exposure from January 1, 2002, to December 31, 2004.

Results.

We found increased rates of nausea among subjects who received treatment with ZDV-3TC-TDF and subjects who received treatment with zidovudine, lamivudine, and indinavir (ZDV-3TC-IDV). Analyses showed that female sex was a risk factor for nausea. Compared with subjects who received treatment with ZDV-3TC-TDF, subjects who received treatment with ZDV-3TC-IDV were less likely to not complete the HIV PEP for occupational exposure.

Conclusion.

Preventive treatment of adverse events may be necessary to ensure completion of HIV PEP.

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 28 , Issue 6 , June 2007 , pp. 695 - 701
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2007

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