Consolidation of medication administration times

Throughout the course of a patient’s hospital stay a patient’s medication administration records can become complex as medications are added and administration times are changed. For example, at our institution, if a prescriber orders a medication every 24 hours, the medication administration time will default to the next hour. If the start time is not critical, the medication could be given at a time when other medications are already scheduled. Additionally if a medication is ordered every 8 hours (default times: 6:00 am, 2:00 pm, and 10:00 pm), modifying the administration times to 9:00 am, 4:00 pm, and 9:00 pm would align better with medications ordered every 12 hours (default times: 9:00 am and 9:00 pm) and would reduce the number of times nurses would need to enter the room and use PPE. We provided guidance to pharmacists to consolidate medication times while considering safety of early or late doses during the transition and potential drug–drug interactions (eg, doxycycline with calcium supplementation). High-risk medications such as antimicrobials, antiepileptic agents, anticoagulants, and immunosuppressive agents required consultation with the provider.

Optimizing pharmacotherapy

We encouraged pharmacists to recommend therapy modifications that maintained both safety and efficacy, while decreasing exposure to HCWs. For example, a patient on twice-daily isophane insulin as an outpatient may be able to switch to once-daily long-acting insulin as an inpatient. This approach later led to the implementation of a streamlined protocol for managing mild-to-moderate diabetic ketoacidosis with subcutaneous insulin. Pharmacists also focused on opportunities to switch patients from intravenous to oral therapy based on our hospital’s protocol as a means to reduce entering patient rooms, since oral therapy only requires 1 visit, but intravenous therapy requires a second visit after the infusion is complete. Furthermore, pharmacists advocated for stopping antibiotics in patients with confirmed SARS-CoV-2 but no microbiologic evidence of bacterial infection. Discontinuing unnecessary antimicrobials reduces the risk of adverse effects including Clostridiodes difficile infection, which would further complicate a patient’s hospital course and likely result in increased use of PPE for additional medication administration.

Therapeutic drug monitoring

At our institution, pharmacists are responsible for vancomycin dosing and monitoring. We encouraged pharmacists to reduce unnecessary testing (eg, uncomplicated skin and soft-tissue infections or anticipated short course of therapy) to help further decrease HCW exposure. If the pharmacist determined that a test was needed, the pharmacist placed a timed order or a phlebotomy or nursing order. We partnered with phlebotomy leadership to determine their high-volume times for routine laboratory tests, and we reviewed their staffing model. Ideal times were identified in the morning and the evening for patients located in both the intensive care units and wards to collect samples for testing vancomycin levels and to minimize PPE use. Pharmacists used these preferred times to obtain samples to test levels or extrapolated levels if needed.

These efforts have reduced unnecessary patient room entry, minimized HCW exposure, and conserved PPE supply. Our interventions serve as a model for leveraging the collaborative relationship between pharmacists and antimicrobial stewardship programs during the COVID-19 pandemic. With some modifications to accommodate other institutions’ work flows, this initiative can be adapted by other antimicrobial stewardship programs and pharmacy departments. During these challenging times, it is imperative to engage in multidisciplinary collaboration to not only keep the patient safe but our own colleagues as well. We hope our project inspires other creative ways for antimicrobial stewardship programs to contribute to efforts to prevent HCW exposure to SARS-CoV-2.