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Ventilator-Associated Pneumonia at a Tertiary-Care Center in a Developing Country: Incidence, Microbiology, and Susceptibility Patterns of Isolated Microorganisms

Published online by Cambridge University Press:  02 January 2015

Zeina A. Kanafani ,
Layla Kara ,
Shady Hayek  and
Souha S. Kanj
Zeina A. Kanafani
Affiliation:
Department of Medicine, Division of Infectious Diseases, Beirut, Lebanon
Layla Kara
Affiliation:
School of Pharmacy, Lebanese American University, Beirut, Lebanon
Shady Hayek
Affiliation:
Department of Surgery, American University of Beirut Medical Center, Beirut, Lebanon
Souha S. Kanj*
Affiliation:
Department of Medicine, Division of Infectious Diseases, Beirut, Lebanon
*
Medicine, Head, Division of Infectious Diseases, Department of Medicine, American University of Beirut Medical Center, P.O. Box 113-6044, Hamra 110 32090, Beirut, Lebanon
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Abstract

Objective:

Ventilator-associated pneumonia (VAP) complicates the course of up to 24% of intubated patients. Data from the Middle East are scarce. The objective of this study was to evaluate the incidence, microbiology, and antimicrobial susceptibility patterns of isolated microorganisms in VAP in a developing country.

Design:

Prospective observational cohort study.

Setting:

The American University of Beirut Medical Center, a tertiary-care center that serves as a major referral center for Lebanon and neighboring countries.

Patients:

All patients admitted to the intensive care and respiratory care units from March to September 2001, and who had been receiving mechanical ventilation for at least 48 hours, were included in the study. Results of samples submitted for culture were recorded and antimicrobial susceptibility testing of isolated pathogens was performed.

Results:

Seventy patients were entered into the study. The incidence of VAP was 47%. Gram-negative bacilli accounted for 83% of all isolates. The most commonly identified organism was Acinetobacter anitratus, followed by Pseudomonas aeruginosa. Fifty percent of all gram-negative bacterial isolates were classified as antibiotic resistant. Compared with patients without VAP, patients with VAP remained intubated for a longer period and stayed in the intensive care unit longer. VAP was not associated with an increased mortality rate.

Conclusion:

Compared with other studies, the results from this referral center in Lebanon indicate a higher incidence of VAP and a high prevalence of resistant organisms. These data are relevant because they direct the choice of empiric antibiotic therapy for VAP.

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 24 , Issue 11 , November 2003 , pp. 864 - 869
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2003

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