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Unnecessary Antimicrobial Use in Patients with Current or Recent Clostridium difficile Infection

Published online by Cambridge University Press:  02 January 2015

Megan K. Shaughnessy ,
William H. Amundson ,
Michael A. Kuskowski ,
Douglas D. DeCarolis ,
James R. Johnson  and
Dimitri M. Drekonja
Megan K. Shaughnessy*
Affiliation:
Minneapolis Veterans Affairs Health Care System, Minneapolis, Minnesota Department of Medicine, University of Minnesota, Minneapolis, Minnesota
William H. Amundson
Affiliation:
University of Minnesota Medical School, Minneapolis, Minnesota
Michael A. Kuskowski
Affiliation:
Minneapolis Veterans Affairs Health Care System, Minneapolis, Minnesota Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota
Douglas D. DeCarolis
Affiliation:
Minneapolis Veterans Affairs Health Care System, Minneapolis, Minnesota College of Pharmacy, University of Minnesota, Minneapolis, Minnesota
James R. Johnson
Affiliation:
Minneapolis Veterans Affairs Health Care System, Minneapolis, Minnesota Department of Medicine, University of Minnesota, Minneapolis, Minnesota
Dimitri M. Drekonja
Affiliation:
Minneapolis Veterans Affairs Health Care System, Minneapolis, Minnesota Department of Medicine, University of Minnesota, Minneapolis, Minnesota
*
250 (Mayo Building) Suite D-416, 420 Delaware Street SE, Minneapolis, MN 55455 ([email protected])
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Abstract

Objective.

To determine the fraction of unnecessary antimicrobial use among patients with current and/or recent Clostridium difficile infection (CDI).

Design.

Retrospective review from January 2004 through December 2006.

Setting.

Minneapolis Veterans Affairs Medical Center (MVAMC).

Participants.

Patients with new-onset CDI diagnosed at the MVAMC without another CDI diagnosis in the prior 30 days.

Methods.

Pharmacy and medical records were reviewed to identify incident CDI cases, non-CDI antimicrobial use during and up to 30 days after completion of CDI treatment, and patient characteristics. Two infectious disease physicians independently assessed non-CDI antimicrobial use, which was classified as unnecessary if not fully indicated. Factors associated with only unnecessary use were identified through univariable and multivariable analysis.

Results.

Of 246 patients with new-onset CDI, 141 (57%) received non-CDI antimicrobials during and/or after their CDI treatment, totaling 2,147 antimicrobial days and 445 antimicrobial courses. The two reviewers agreed regarding the necessity of antimicrobials in more than 99% of antimicrobial courses (85% initially, 14% after discussion). Seventy-seven percent of patients received at least 1 unnecessary antimicrobial dose, 26% of patients received only unnecessary antimicrobials, and 45% of total non-CDI antimicrobial days included unnecessary antimicrobials. The leading indications for unnecessary antimicrobial use were putative urinary tract infection and pneumonia. Drug classes frequently used unnecessarily were fluoroquinolones and β-lactams.

Conclusions.

Twenty-six percent of patients with recent CDI received only unnecessary (and therefore potentially avoidable) antimicrobials. Heightened awareness and caution are needed when antimicrobial therapy is contemplated for patients with recent CDI.

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 34 , Issue 2 , February 2013 , pp. 109 - 116
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2013 

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