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Role of Unit-Specific Combination Antibiograms for Improving the Selection of Appropriate Empiric Therapy for Gram-Negative Pneumonia

Published online by Cambridge University Press:  02 January 2015

Jason M. Pogue ,
Cesar Alaniz ,
Peggy L. Carver ,
Melissa Pleva ,
Duane Newton  and
Daryl D. DePestel
Jason M. Pogue*
Affiliation:
Department of Clinical, Social and Administrative Sciences, University of Michigan College of Pharmacy, and Department of Pharmacy Services, University of Michigan Health System, Ann Arbor, Michigan
Cesar Alaniz
Affiliation:
Department of Clinical, Social and Administrative Sciences, University of Michigan College of Pharmacy, and Department of Pharmacy Services, University of Michigan Health System, Ann Arbor, Michigan
Peggy L. Carver
Affiliation:
Department of Clinical, Social and Administrative Sciences, University of Michigan College of Pharmacy, and Department of Pharmacy Services, University of Michigan Health System, Ann Arbor, Michigan
Melissa Pleva
Affiliation:
Department of Clinical, Social and Administrative Sciences, University of Michigan College of Pharmacy, and Department of Pharmacy Services, University of Michigan Health System, Ann Arbor, Michigan
Duane Newton
Affiliation:
Clinical Microbiology Laboratories and Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan
Daryl D. DePestel
Affiliation:
Department of Clinical, Social and Administrative Sciences, University of Michigan College of Pharmacy, and Department of Pharmacy Services, University of Michigan Health System, Ann Arbor, Michigan
*
6071 West Outer Drive, Detroit, MI 48235 ([email protected])
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Abstract

In an effort to improve the selection of appropriate empiric gram-negative therapy for pneumonia, we examined intensive care unit-specific combination antibiograms. These antibiograms were able to predict appropriate empiric gram-negative therapy. Empiric combination therapy based on unit-specific combination antibiograms may aid in the selection of therapy for gram-negative pneumonia.

Type
Concise Communication
Information
Infection Control & Hospital Epidemiology , Volume 32 , Issue 3 , March 2011 , pp. 289 - 292
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2011

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References

1.American Thoracic Society, Infectious Diseases Society of America. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med 2005;171:388–416.CrossRefGoogle Scholar
2.Binkley, S, Fishman, NO, LaRosa, LA, et al.Comparison of unit-specific and hospital-wide antibiograms: potential implications for selection of empirical antimicrobial therapy. Infect Control Hosp Epidemiol 2006;27:682–687.CrossRefGoogle ScholarPubMed
3.Mizuta, M, Linkin, DR, Nachamkin, I, et al.Identification of optimal combinations for empirical dual antimicrobial therapy of Pseudomonas aeruginosa infection: potential role of a combination antibiogram. Infect Control Hosp Epidemiol 2006;27:413–415.CrossRefGoogle ScholarPubMed
4.Apisarnthanarak, A, Mundy, LM. Role of combination antibiogram in empirical treatment of infection due to multidrug-resistant Acinetobacter baumannii. Infect Control Hosp Epidemiol 2008;29:678–679.CrossRefGoogle ScholarPubMed
5.Christoff, J, Tolentino, J, Mawdsley, E, Matushek, MS, Pitrak, D, Weber, SG. Optimizing empirical antimicrobial therapy for infection due to gram-negative pathogens in the intensive care unit: utility of a combination antibiogram. Infect Control Hosp Epidemiol 2010;31:256–261.CrossRefGoogle ScholarPubMed
6.Clinical and Laboratory Standards Institute (CLSI). Performance Standards for Antimicrobial Susceptibility Testing—Eighteenth Informational Supplement. Wayne, PA: CLSI; 2008. CLSI document M100-S18.Google Scholar
7.Gandhi, TN, DePestel, DD, Collins, CD, Nagel, J, Washer, LL. Managing antimicrobial resistance in the intensive care unit. Crit Care Med 2010;38(suppl):S315–S323.CrossRefGoogle Scholar
8.Dellit, TH, Owens, RC, McGowan, JE Jr, et al.Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America guidelines for developing an institutional program to enhance antimicrobial stewardship. Clin Infect Dis 2007;44:159–177.CrossRefGoogle Scholar