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Oral vancomycin prophylaxis for the prevention of Clostridium difficile infection: A systematic review and meta-analysis

Published online by Cambridge University Press:  29 June 2020

Sumbal Babar ,
Bara El Kurdi Open the ORCID record for Bara El Kurdi [Opens in a new window] ,
Mahmoud El Iskandarani ,
Ibrahim Haddad ,
Zaid Imam Open the ORCID record for Zaid Imam [Opens in a new window] ,
Mohammad Alomari ,
James Myers  and
Jonathan Moorman
Sumbal Babar
Affiliation:
Department of Internal Medicine, East Tennessee State University, Johnson City, Tennessee
Bara El Kurdi*
Affiliation:
Department of Internal Medicine, East Tennessee State University, Johnson City, Tennessee
Mahmoud El Iskandarani
Affiliation:
Department of Internal Medicine, East Tennessee State University, Johnson City, Tennessee
Ibrahim Haddad
Affiliation:
Department of Internal Medicine, East Tennessee State University, Johnson City, Tennessee
Zaid Imam
Affiliation:
Department of Internal Medicine, William Beaumont Hospital, Royal Oak, Michigan
Mohammad Alomari
Affiliation:
Department of Internal Medicine, Cleveland Clinic Foundation, Cleveland, Ohio
James Myers
Affiliation:
Department of Internal Medicine, East Tennessee State University, Johnson City, Tennessee Division of Infectious Diseases, East Tennessee State University, Johnson City, Tennessee
Jonathan Moorman
Affiliation:
Division of Infectious Diseases, East Tennessee State University, Johnson City, Tennessee
*
Author for correspondence: Bara El Kurdi, E-mail: [email protected]
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Abstract

Objective:

Recently, oral vancomycin prophylaxis (OVP) has been suggested for the prevention of Clostridium difficile infection (CDI). We conducted a systematic review and meta-analysis to investigate the efficacy and safety of this approach.

Design:

Systematic review and meta-analysis.

Methods:

We conducted a computerized search of MEDLINE, EMBASE, and Cochrane databases from inception to March 2019 for publications investigating OVP for CDI prevention. Results were screened for eligibility. Relevant data were extracted and analyzed. Publication bias was assessed using the Egger test.

Results:

Ultimately, 8 retrospective studies and 1 prospective study examining 2174 patients, published between 2016 and 2019 were included in the review. OVP was associated with decreased CDI (odds ratio, 0.263; 95% confidence interval, 0.13–0.52) with considerable heterogeneity (I2 = 61%). Meta-regression showed that total daily dose of OVP correlated with CDI, explaining 100% of heterogeneity between studies. Furthermore, 3 studies evaluated the risk of vancomycin-resistant enterococci (VRE) infection after OVP and found no significant increase.

Conclusion:

Our results suggest that OVP might decrease CDI rates in at-risk populations, although this conclusion should be interpreted with caution. Higher daily doses of OVP might increase CDI. Although the use of OVP in high-risk patients may reduce CDI, this suggestion has yet to be validated by prospective blinded randomized controlled trials.

Type
Original Article
Information
Infection Control & Hospital Epidemiology , Volume 41 , Issue 11 , November 2020 , pp. 1302 - 1309
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Copyright
© 2020 by The Society for Healthcare Epidemiology of America. All rights reserved.

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