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Octenidine Hydrochloride for the Care of Central Venous Catheter Insertion Sites in Severely Immunocompromised Patients

Published online by Cambridge University Press:  21 June 2016

Andreas Tietz ,
Reno Frei ,
Marc Dangel ,
Dora Bolliger ,
Jakob R. Passweg ,
Alois Gratwohl  and
Andreas F. Widmer
Andreas Tietz
Affiliation:
Division of Hospital Epidemiology, University Hospital Basel, Basel, Switzerland
Reno Frei
Affiliation:
Bacteriology Laboratory, University Hospital Basel, Basel, Switzerland
Marc Dangel
Affiliation:
Division of Hospital Epidemiology, University Hospital Basel, Basel, Switzerland
Dora Bolliger
Affiliation:
Division of Hospital Epidemiology, University Hospital Basel, Basel, Switzerland
Jakob R. Passweg
Affiliation:
Passweg and Gratwohl are from the Division of Hematology, University Hospital Basel, Basel, Switzerland
Alois Gratwohl
Affiliation:
Bacteriology Laboratory, University Hospital Basel, Basel, Switzerland
Andreas F. Widmer*
Affiliation:
Division of Hospital Epidemiology, University Hospital Basel, Basel, Switzerland
*
Division of Hospital Epidemiology, University Hospital Basel, Petersgraben 4, CH-4031 Basel, Switzerland, [email protected]
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Abstract

Objective:

To determine the efficacy and tolerability of octenidine hydrochloride, a non-alcoholic skin antiseptic, for the care of central venous catheter (CVC) insertion sites.

Design:

Prospective, observational study.

Setting:

Bone marrow transplantation unit of a university hospital.

Patients:

All consecutive patients with a nontunneled CVC were enrolled prospectively after informed consent.

Methods:

Octenidine hydrochloride (0.1%) was applied for disinfection at the CVC insertion site during dressing changes. The following cultures were performed weekly as well as at the occurrence of any systemic inflammatory response syndrome criteria: cultures of the skin surrounding the CVC entry site, cultures of the three-way hub connected to the CVC, blood cultures, and cultures of the CVC tip on removal. Enhanced microbiological methods (skin swabs of a 24-cm2 standardized area, roll plate, and sonication of catheter tips) were applied.

Results:

One hundred thirty-five CVCs were inserted in 62 patients during the study period and remained for a mean period of 19.1 days, corresponding to 2,462 catheter-days. Bacterial density at the insertion site declined substantially over time, and most cultures became negative 2 weeks after insertion. Only 6 patients had a documented catheter-related bloodstream infection. The incidence density was 2.39 catheter infections per 1,000 catheter-days. No side effects were noted with application of the antiseptic.

Conclusions:

Disinfection with a skin antiseptic that contains octenidine hydrochloride is highly active and well tolerated. It leads to a decrease in skin colonization over time and may be a new option for CVC care.

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 26 , Issue 8 , August 2005 , pp. 703 - 707
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2005

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