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Mupirocin Resistance: Clinical and Molecular Epidemiology

Published online by Cambridge University Press:  02 January 2015

Suzanne F. Bradley ,
Mary A. Ramsey ,
Teresa M. Morton  and
Carol A. Kauffman
Suzanne F. Bradley*
Affiliation:
Divisions Of Infectious Diseases and Geriatric Medicine, Department of Internal Medicine, University of Michigan Medical Center, Department of Veterans Affairs, Ann Arbor, Michigan Department of Biology, Eastern Michigan University, Ypsilanti, Michigan
Mary A. Ramsey
Affiliation:
Divisions Of Infectious Diseases and Geriatric Medicine, Department of Internal Medicine, University of Michigan Medical Center, Department of Veterans Affairs, Ann Arbor, Michigan Department of Biology, Eastern Michigan University, Ypsilanti, Michigan
Teresa M. Morton
Affiliation:
Divisions Of Infectious Diseases and Geriatric Medicine, Department of Internal Medicine, University of Michigan Medical Center, Department of Veterans Affairs, Ann Arbor, Michigan Department of Biology, Eastern Michigan University, Ypsilanti, Michigan
Carol A. Kauffman
Affiliation:
Divisions Of Infectious Diseases and Geriatric Medicine, Department of Internal Medicine, University of Michigan Medical Center, Department of Veterans Affairs, Ann Arbor, Michigan Department of Biology, Eastern Michigan University, Ypsilanti, Michigan
*
GRECC IIG, VA Medical Center, 2215 Fuller Road, Ann Arbor, MI 48105
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Abstract

The antistaphylococcal activity of topical mupirocin has made it an attractive agent for the treatment of asymptomatic colonization with Staphylococcus aureus. Increasing use has been associated with the emergence of mupirocin resistance in staphyloccoci, and failure of therapy has been associated with the isolation of strains exhibiting high-level resistance (MIC >500 μg/mL). Fortunately, low-level mupirocin resistance (MIC <100 μg/mL) occurs most commanly. Because a novel gene encoding for mupirocin resistance resides in both low-level and high-level resistant strains, the emergence of low-level mupirocin resistance may not be as epidemiologically insignificant as previously thought.

Type
Molecular Hospital Epidemiology
Information
Infection Control & Hospital Epidemiology , Volume 16 , Issue 6 , June 1995 , pp. 354 - 358
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1995

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