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Low Frequency of Endemic Patient-to-Patient Transmission of Antibiotic-Resistant Gram-Negative Bacilli in a Pediatric Intensive Care Unit

Published online by Cambridge University Press:  02 January 2015

Joan Zoltanski*
Affiliation:
Division of Pharmacology and Critical Care, Rainbow Babies and Children’s Hospital, Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio
Michael Dul
Affiliation:
Division of Pharmacology and Critical Care, Rainbow Babies and Children’s Hospital, Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio
Mary Ann O’Riordan
Affiliation:
Division of Pharmacology and Critical Care, Rainbow Babies and Children’s Hospital, Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio
Jeffrey Blumer
Affiliation:
Division of Pharmacology and Critical Care, Rainbow Babies and Children’s Hospital, Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio
Philip Toltzis
Affiliation:
Division of Pharmacology and Critical Care, Rainbow Babies and Children’s Hospital, Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio
*
Rainbow Babies and Children's Hospital 11100 Euclid Avenue, Cleveland, OH 44106 ([email protected])

Extract

We sought to determine the frequency of horizontal transmission of antibiotic-resistant gram-negative bacilli (ARGNB) in a pediatric intensive care unit during a nonoutbreak period. Among 5,300 admissions over 39 consecutive months, 13 ARGNB clusters involving 35 children were identified by pulsed-filed gel electrophoresis analysis, which suggests that person-to-person transmission was uncommon.

Type
Concise Communication
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2011

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References

1.Giske, CG, Monnet, DL, Cars, O, Carmeli, Y. Clinical and economic impact of common multidrug-resistant gram-negative bacilli. Antimicrobial Agents Chemother 2008;52:813821.Google Scholar
2.Toltzis, P, Dul, M, O'Riordan, MA, Melnick, D, Lo, M, Blumer, J. Meropenem use and colonization by antibiotic-resistant gram-negative bacilli in a pediatric intensive care unit. Pediatr Crit Care Med 2009;10:4954.CrossRefGoogle Scholar
3.Tenover, FC, Arbeit, RD, Goering, RV, et al.Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J Clin Microbiol 1995;33:22332239.Google Scholar
4.Johnson, JK, Smith, G, Lee, MS, et al.The role of patient-to-patient transmission in the acquisition of imipenem-resistant Pseudomonas aeruginosa colonization in the intensive care unit. J Infect Dis 2009;200:900905.CrossRefGoogle ScholarPubMed
5.Ortega, B, Groeneveld, AB, Schultsz, C. Endemic multidrug-resistant Pseudomonas aeruginosa in critically ill patients. Infect Control Hosp Epidemiol 2004;25:825831.Google Scholar
6.Barbolla, RE, Centron, D, Maimone, S, et al.Molecular epidemiology of Acinetobacter baumannii spread in an adult intensive care unit under an endemic setting. Amer J Infect Control 2008;36:444452.CrossRefGoogle Scholar
7.Markogiannakis, A, Fildisis, G, Tsiplakou, S, et al.Cross-transmission of multidrug-resistant Acinetobacter baumannii clonal strains causing episodes of sepsis in a trauma intensive care unit. Infect Control Hosp Epidemiol 2008;29:410417.Google Scholar
8.Lidsky, K, Hoyen, C, Salvator, A, Rice, LB, Toltzis, P. Antibiotic-resistant gram-negative organisms in pediatric chronic-care facilities. Clin Infect Dis 2002;34(6):760766.CrossRefGoogle ScholarPubMed
9.Leader, S, Kohlhase, K. Recent trends in severe respiratory syncytial virus (RSV) among US infants, 1997 to 2000. J Pediatr 2003;143(Suppl 5):S127S132.Google Scholar
10.Macartney, KK, Gorelick, MH, Manning, ML, Hodinka, RL, Bell, LM. Nosocomial respiratory syncytial virus infections: the cost-effectiveness and cost-benefit of infection control. Pediatrics 2000;106(3):520526.CrossRefGoogle ScholarPubMed