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Lost in Translation? Reliability of Assessing Inpatient Antimicrobial Appropriateness With Use of Computerized Case Vignettes

Published online by Cambridge University Press:  02 January 2015

David N. Schwartz ,
Ulysses S. Wu ,
Rosie D. Lyles ,
Yingxu Xiang ,
Piotr Kieszkowski ,
Bala Hota  and
Robert A. Weinstein
David N. Schwartz*
Affiliation:
Stroger Hospital of Cook County, Chicago, Illinois Rush Medical College, Chicago, Illinois
Ulysses S. Wu
Affiliation:
Stroger Hospital of Cook County, Chicago, Illinois Rush Medical College, Chicago, Illinois
Rosie D. Lyles
Affiliation:
Stroger Hospital of Cook County, Chicago, Illinois
Yingxu Xiang
Affiliation:
Stroger Hospital of Cook County, Chicago, Illinois
Piotr Kieszkowski
Affiliation:
Stroger Hospital of Cook County, Chicago, Illinois
Bala Hota
Affiliation:
Stroger Hospital of Cook County, Chicago, Illinois Rush Medical College, Chicago, Illinois
Robert A. Weinstein
Affiliation:
Stroger Hospital of Cook County, Chicago, Illinois Rush Medical College, Chicago, Illinois
*
Division of Infectious Diseases, Stroger Hospital of Cook County, 1901 W. Harrison St., Chicago, IL 60612 ([email protected])
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Abstract

Objective.

To describe and measure reliability of a computer-assisted method of case vignette assembly and expert review to assess the appropriateness of antimicrobial therapy for hospitalized adults.

Design.

Feasibility and reliability analysis of computer-assisted tool used to compare the effects of antimicrobial stewardship interventions.

Setting.

Public teaching hospital.

Patients.

Randomly selected adult antimicrobial recipients admitted to inpatient medicine services.

Methods.

Clinical data abstracted from 504 paper medical records were merged with computerized laboratory and pharmacy data to assemble case vignettes that underwent expert review for appropriateness. We performed 3 validations, as follows: data for 35 vignettes abstracted independently by 2 research assistants were assessed for interrater agreement, expert review of 24 vignettes was compared with review of the corresponding paper medical records, and interrater reliability of antimicrobial appropriateness assessments by 2 experts was determined for 70 case vignettes.

Results.

Vignette assembly and expert review each required 10–12 minutes per case. Potentially important discrepancies occurred in 0%–32% of clinical findings abstracted independently by 2 research assistants. Expert review of 24 vignettes and the corresponding full paper medical records yielded fair agreement (kappa, 0.30). The 2 experts identified inappropriate initial antimicrobial therapy in 67% and 61% of case vignettes reviewed independently; interrater agreement was improved after sequential case discussion and stringent application of appropriateness criteria (kappa, 0.72).

Conclusions.

Our case vignette assembly and expert review method is efficient, but improvements in both technical and human performance are needed to be able to yield valid estimates of the prevalence of inappropriate antimicrobial use. Assessments of antimicrobial appropriateness require validation.

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 30 , Issue 2 , February 2009 , pp. 163 - 171
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2009

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