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Issues in the Management of Resistant Bacteria in Long-Term–Care Facilities

Published online by Cambridge University Press:  02 January 2015

Suzanne F. Bradley
Suzanne F. Bradley*
Affiliation:
Divisions of Geriatric Medicine and Infectious Disease, Department of Internal Medicine, Veterans' Affairs Health Systems, University of Michigan Medical School, Ann Arbor, Michigan
*
GRECC UG, Veterans'Affairs Health Systems, 2215 Fuller Rd, Ann Arbor, MI 48105
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Abstract

The prevalence of antibiotic-resistant bacteria in the long-term–care setting and the risk to nursing home residents is still unknown. Few studies have been done in community-based nursing homes, and most have focused on colonization rather than infection rates. Concerns about methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci have been expressed most often, while relatively scant attention has been paid to the problem of antibiotic resistance in gram-negative bacilli. Antibiotic resistance precautions need to be developed for nursing homes that are simple, effective, inexpensive, and recognize the unique rehabilitative and long-term custodial missions of chronic-care facilities.

Type
Topics in Long-Term Care
Information
Infection Control & Hospital Epidemiology , Volume 20 , Issue 5 , May 1999 , pp. 362 - 366
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1999

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References

1. Smith, PW, Rusnak, PG. Infection prevention and control in the long-term-care facility. Infect Control Hosp Epidemiol 1997;18:831–849.Google Scholar
2. Strausbaugh, LJ, Crossley, KB, Nurse, BA, Thrupp, LD, SHEA Long-Term-Care Committee. Antimicrobial resistance in long-term-care facilities. Infect Control Hosp Epidemiol 1996;17:129–140.CrossRefGoogle ScholarPubMed
3. Yoshikawa, TT. VRE, MRSA PRP, and DRGNB in LTCF: lessons to be learned from this alphabet. J Am Geriatr Soc 1998;46:241–243.CrossRefGoogle ScholarPubMed
4. Bradley, SF. Methicillin-resistant Staphylococcus aureus in nursing homes: epidemiology, prevention, and management. Drugs and Aging 1997;10:185–198.Google Scholar
5. Chenoweth, CE, Bradley, SF, Terpenning, MS, Zarins, LT, Ramsey, MA Schaberg, DR, et al. Colonization and transmission of high-level gentam-icin-resistant enterococci in a long-term care facility. Infect Control Hosp Epidemiol 1994;15:703–709.CrossRefGoogle ScholarPubMed
6. Zervos, MJ, Terpenning, MS, Schaberg, DR, Therasse, PM, Mendendorp, SV, Kauffman, CA. High-level aminoglycoside-resistant enterococci: colonization of nursing home and acute care hospital patients. Arch Intern Med 1987;147:1591–1594.CrossRefGoogle ScholarPubMed
7. Gordts, B, Van Landuyt, H, leven, M, Vandamme, P, Goossens, H. Vancomycin-resistant enterococci colonizing the intestinal tracts of hospitalized patients. J Clin Microbiol 1995;33:2842–2846.Google Scholar
8. Bonilla, HF, Zervos, MA Lyons, MJ, Bradley, SF, Hedderwick, SA Ramsey, MA et al. Colonization with vancomycin-resistant Enterococcus faecium: comparison of a long-term care unit with an acute-care hospital Infect Control Hosp Epidemiol 1997;18:333–339.Google ScholarPubMed
9. Nuorti, JP, Butler, JC, Crutcher, JM, Guevara, R, Welch, D, Holder, P, et al. An outbreak of multidrug-resistant pneumococcal pneumonia and bacteremia among unvaccinated nursing home residents. N Engl J Med 1998;338:1861–1868.Google Scholar
10. Mannheimer, SB, Riley, LW, Roberts, RB. Association of penicillin-resistant pneumococci with residence in a pediatric chronic care facility. J Infect Dis 1996;174:513–519.CrossRefGoogle Scholar
11. Leistevuo, T, Toivonen, P, Osterblad, M, Kuistila, M, Kahara, A, Lehtonen, A, et al. Problem of antimicrobial resistance of fecal aerobic gram-negative bacilli in the elderly. Antimicrob Agents Chemother 1996;40:2399–2403.Google Scholar
12. Wingard, E, Shlaes, JH, Mortimer, FA, Shlaes, DM. Colonization and cross-colonization of nursing home patients with trimethoprim-resistant gram-negative bacilli. Clin Infect Dis 1993;16:75–81.CrossRefGoogle ScholarPubMed
13. MacArthur, RD, Lehman, MH, Currie-McCumber, CA, Shlaes, DM. The epidemiology of gentamicin-resistant Pseudomonas aeruginosa on an intermediate care unit. Am J Epidemiol 1988;128:821–827.CrossRefGoogle Scholar
14. Shlaes, DM, Lehman, M-H, Currie-McCumber, CA Kim, CH, Floyd, R. Prevalence of colonization with antibiotic resistant gram-negative bacilli in a nursing home care unit: the importance of cross-colonization as documented by plasmid analysis. Infect Control 1986;7:538–545.CrossRefGoogle Scholar
15. Terpenning, MS, Bradley, SF, Wan, JY, Chenoweth, CE, Jorgensen, KA, Kauffman, CA. Colonization and infection with antibiotic-resistant bacteria in a long-term care facility. J Am Geriatr Soc 1994;42:1062–1069.Google Scholar
16. Bradley, SF, Terpenning, MS, Ramsey, MA Zarins, LT, Jorgensen, KA Sottile, WS, et al. Methicillin-resistant Staphylococcus aureus: colonization and infection in a long-term care facility. Ann Intern Med 1991;115:417422.Google Scholar
17. Bjork, DT, Pelletier, LL, Tight, RR Urinary tract infections with antibiotic resistant organisms in catheterized nursing home patients. Infect Control 1984;5:173–176.CrossRefGoogle ScholarPubMed
18. Gaynes, RP, Weinstein, RA, Chamberlain, W, Kabins, SA. Antibiotic-resistant flora in nursing home patients admitted to the hospital. Arch Intern Med 1985;145:1804–1807.CrossRefGoogle ScholarPubMed
19. Weinstein, RA Nathan, C, Gruensfelder, R, Kabins, SA. Endemic aminoglycoside resistance in gram-negative bacilli: epidemiology and mechanisms. J Infed Dis 1980;141:338–345.Google Scholar
20. Weinstein, RA Resistant bacteria and infection control in nursing home and hospital. Bull N Y Acad Med 1987;63:337–344.Google ScholarPubMed
21. Brennen, C, Wagener, MM, Muder, RR. Vancomycin-resistant Enterococcus faecium in a long-term care facility. J Am Geriatr Soc 1998;46:157–160.Google Scholar
22. Schoonmaker, DJ, Bopp, LH, Baltch, AL, Smith, RP, Rafferty, ME, George, M. Genetic analysis of multiple vancomycin-resistant Enterococcus isolates obtained serially from two long-term care patients. J Clin Microbiol 1998;36:2105–2108.CrossRefGoogle ScholarPubMed
23. Sanford, MD, Widmer, AF, Bale, MJ, Jones, RN, Wenzel, RR Efficient detection and long-term persistence of the carriage of methicillin-resistant Staphylococcus aureus . Clin Infed Dis 1994;19:1123–1128.CrossRefGoogle ScholarPubMed
24. Fraise, AP, Mitchell, K, O'Brien, SJ, Oldfield, K, Wise, R. Methicillin-resistant Staphylococcus aureus (MRSA) in nursing homes in a major UK city: an anonymized point prevalence survey. Epidemiol Infect 1997;118:1–5.CrossRefGoogle Scholar
25. Hsu, CCS. Serial survey of methicillin-resistant Staphylococcus aureus nasal carriage among residents in a nursing home. Infed Control Hosp Epidemiol 1991;12:416421.Google ScholarPubMed
26. Huovinen, P. Trimethoprim-resistant Escherichia coli in a geriatric hospital. J Infect 1984;8:145–148.CrossRefGoogle Scholar
27. Flournoy, DJ. Antimicrobial susceptibilities of bacteria from nursing home residents in Oklahoma. Gerontology 1994;40:53–56.CrossRefGoogle ScholarPubMed
28. Muder, RR, Brennen, C, Wagener, MM, Vickers, RM, Rihs, JD, Hancock, GA, et al. Mefticillin-resistant staphylococcal colonization and infection in a long-term care unit. Ann Intern Med 1991;114:107–112.CrossRefGoogle Scholar
29. Mulhausen, PL, Harreil, LJ, Weinberger, M, Kochersberger, GG, Feusser, JR. Contrasting methicillin-resistant Staphylococcus aureus colonization in Veterans' Affairs and community nursing homes. Am J Med 1996;100:24–31.Google Scholar
30. Spindel, SJ, Strausbaugh, LJ, Jacobsen, C. Infections caused by Staphylococcus aureus in a Veterans' Affairs nursing home care unit: a 5-year experience. Infect Control Hosp Epidemiol 1995;16:217–223.Google Scholar
31. Aeilts, GD, Sapico, FL, Canawati, HN, Malik, GM, Montgomerie, JZ, et al. Methicillin-resistant Staphylococcus aureus colonization and infection in a rehabilitation facility. J Clin Microbiol 1982;16:218–223.CrossRefGoogle Scholar
32. Storch, GA Radcliff, JL, Meyer, PL, Hinricks, JH, et al. Methicillin-resistant Staphylococcus aureus in a nursing home. Infed Control 1987;8: 24–29.Google Scholar
33. Haglund, LA Istre, GR, Pickett, DA Welch, DF, Fine, DR the Pneumococcus study group. Invasive pneumococcal disease in central Oklahoma: emergence of high-level penicillin resistance and multiple antibiotic resistance. J Infect Dis 1993;168:1532–1436.Google Scholar
34. Plouffe, JF, Breiman, RF, Facklam, RR, Franklin County Pneumonia Study Group. Bacteremia with Streptococcus pneumoniae: implications for therapy and prevention. JAMA 1996;275:194–198.CrossRefGoogle ScholarPubMed
35. Centers for Disease Control and Prevention. Outbreaks of pneumococcal pneumonia among unvaccinated residents in chronic-care facilities— Massachusetts, October 1995, Oklahoma, February 1996, and Maryland, May-June 1996. MMWR 1997;46:60–62.Google Scholar
36. Muder, RR, Brennen, C, Drennings, SD, Stout, JE, Wagener, MM. Multiply antibiotic-resistant gram-negative bacilli in a long-term-care facility: a case-control study of patient risk factors and prior antibiotic use. Infed Control Hosp Epidemiol 1997;18:809–813.Google Scholar
37. Canawati, HN, El-Farra, R, Seymour, J, Shimashita, J, Dunn, D, Montgomerie, JZ, et al. Ciprofloxacin-resistant Escherichia coli emerging in a rehabilitation medical center. Diagn Microbiol Infed Dis 1997;29:133–138.Google Scholar
38. Rice, LB, Eckstein, EC, DeVente, J, Shlaes, DM. Ceftazidime-resistant Klebsiella pneumoniae isolates recovered at the Cleveland Department of Veterans' Affairs Medical Center. Clin Infect Dis 1996;23:118–124.CrossRefGoogle ScholarPubMed
39. Patterson, JE, Madden, GM, Krisunas, EP, Masecar, B, Hierholzer, WJ, Zervos, MJ, et al. A nosocomial outbreak of ampicillin-resistant Haemophilus influenzae type b in a geriatric unit. J Infect Dis 1988;157:1002–1007.Google Scholar
40. Bradford, PA Urban, C, Jaiswal, A Mariano, N, Rasmussen, BA Projan, SJ, et al. SHV-7, a novel cefotaxime-hydrolyzing β-lactamase, identified in Escherichia coli isolates from hospitalized nursing home patients. Antimicrob Agents Chemother 1995;39:899–905.Google Scholar
41. Rice, LB, Willey, SH, Papanicolaou, GA Medeiros, AA Eliopoulos, EM, Moellering, RC, et al. Outbreak of ceftazidime resistance caused by extended-spectrum β-lactamases at a Massachusetts chronic-care facility. Antimicrob Agents Chemother 1990;34:2193–2199.CrossRefGoogle Scholar
42. Thomas, JC, Bridge, J, Waterman, S, Vogt, J, Kilman, L, Hancock, G. Transmission and control of methicillin-resistant Staphylococcus aureus in a skilled nursing facility. Infed Control Hosp Epidemiol 1989;10:106–110.Google Scholar
43. Boyce, JM, Jackson, MM, Pugliese, G, Batt, MD, Fleming, D, Garner, JS, et al. Methicillin-resistant Staphylococcus aureus (MRSA): a briefing for acute care hospitals and nursing facilities. Infect Control Hosp Epidemiol 1994;15:105–115.Google Scholar
44. Crossley, K, the Long-Term-Care Committee of the Society for Healthcare Epidemiology of America. Vancomycin-resistant enterococci in long-term care facilities. Infect Control Hosp Epidemiol 1998;19:521–525.Google Scholar
45. Musher, DM. Pneumococcal outbreaks in nursing homes. N Engl J Med 1998;338:1915–1916.CrossRefGoogle ScholarPubMed
46. Kauffman, CA Terpenning, MS, He, X, Zarins, LT, Ramsey, M, Jorgensen, KA, et al. Attempts to eradicate methicillin-resistant Staphylococcus aureus from a long-term care facility with the use of mupirocin ointment Am J Med 1993;94:371–378.Google Scholar
47. Strausbaugh, LJ, Jacobson, C, Sewell, DL, Potter, S, Ward, TT. Antimicrobial therapy for methicillin-resistant Staphylococcus aureus colonization in residents and staff of a Veterans' Affairs nursing home care unit Infect Control Hosp Epidemiol 1992;13:151–159.Google Scholar