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Incidence of Nosocomial Aspergillosis in Patients with Leukemia Over a Twenty-Year Period

Published online by Cambridge University Press:  21 June 2016

Linda L. Klimowski ,
Coleman Rotstein  and
K. Michael Cummings
Linda L. Klimowski
Affiliation:
Department of Medical Technology, State University of Nexo York at Buffalo, Buffalo, New York
Coleman Rotstein*
Affiliation:
Departments of Medical Oncology, Roswell Park Memorial Institute, Buffalo, New York Division of Infectious Diseases, State University of New York at Buffalo, Buffalo, New York
K. Michael Cummings
Affiliation:
Cancer Control and Epidemiology, Roswell Park Memorial Institute, Buffalo, New York
*
McMaster Medical Unit, Henderson General Hospital, 711 Concession Street, Hamilton, Ontano L8V IC3, Canada
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Abstract

The incidence of invasive nosocomial aspergillosis was studied in leukemia patients at an oncology center from 1964 to 1983. A total of 97 cases of aspergillosis occurred in 1,866 patients, yielding an overall case rate of 5.2 cases per 100 patients and an incidence rate of 9.1 per 10,000 patient days. The highest incidence rate was in patients with chronic myelogenous leukemia (13.7 cases per 10,000 patient days), followed by patients with acute myelogenous leukemia (10.6 cases per 10,000 patient days). Subdividing patients after 1978 into those receiving bone marrow transplantation and those who did not demonstrated the predisposition of transplant recipients to aspergillosis. The rates of aspergillosis among those patients who did not receive a bone marrow transplant were highest for patients with acute myelogenous leukemia. Increases in the annual rates of aspergillosis over time coincided with the level of internal renovation activity and major construction projects upwind of patient care facilities.

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 10 , Issue 7 , July 1989 , pp. 299 - 305
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1989

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