Hostname: page-component-78c5997874-ndw9j Total loading time: 0 Render date: 2024-11-19T11:45:04.670Z Has data issue: false hasContentIssue false
  • English
  • Français

The Importance of Surveillance Stool Cultures During Periods of Severe Neutropenia

Published online by Cambridge University Press:  02 January 2015

Carol L. Wells ,
Patricia Ferrieri ,
Daniel J. Weisdorf  and
Frank S. Rhame
Carol L. Wells*
Affiliation:
Departments of Medicine, Pediatrics, and Laboratory Medicine & Pathology, University of Minnesota, Minneapolis, Minnesota
Patricia Ferrieri
Affiliation:
Departments of Medicine, Pediatrics, and Laboratory Medicine & Pathology, University of Minnesota, Minneapolis, Minnesota
Daniel J. Weisdorf
Affiliation:
Departments of Medicine, Pediatrics, and Laboratory Medicine & Pathology, University of Minnesota, Minneapolis, Minnesota
Frank S. Rhame
Affiliation:
Departments of Medicine, Pediatrics, and Laboratory Medicine & Pathology, University of Minnesota, Minneapolis, Minnesota
*
Box 198 Mayo, University of Minnesota, Minneapolis, MN 55455
Get access Rights & Permissions [Opens in a new window]

Abstract

The correlation of fecal gram-negative bacilli (GNB), neutropenia, and bacteremia was studied in 45 bone marrow transplant recipients. Weekly stool cultures were prospectively monitored for GNB resistant to routine prophylactic and empiric antimicrobial agents. Seven cases of GNB bacteremia occurred in 45 patients described as follows. Twenty-three patients had no fecal or blood GNB. Fifteen patients had fecal GNB and no blood GNB; three of these latter patients had ≤50/mm3 circulating white blood cells (WBC) at the time of isolation of fecal GNB but two of the three were concurrently receiving appropriate empiric antibiotics. Two patients had blood GNB but no fecal GNB: one patient had a trimethoprim/sulfamethoxazole (TMP-SMZ)-sensitive isolate that would not be detectable in the feces by our methodology and one patient had feces analyzed only after the bacteremic event. Five patients had fecal GNB and blood GNB: one of these patients did not have a fecal sample analyzed prior to bacteremia but the remaining four patients had the same species/antibiogram of GNB isolated from the feces two to three days prior to the detection of bacteremia. Thus, the fecal GNB could have been used to predict the antibiogram of the subsequent blood GNB. In addition, all four of these latter bacteremic patients had ≤50/mm3 circulating WBC at the time of documented fecal GNB. Thus, bone marrow transplant recipients with fecal GNB coupled with severe neutropenia (≤50/mm3 circulating WBC) were more likely to develop bacteremia (P<0.02) than were those with fecal GNB and ≤50/mm3 circulating WBC.

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 8 , Issue 8 , August 1987 , pp. 317 - 319
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1987

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Young, LS, Prophylaxis in neutropenic patients. J Infect Dis 1983;147:611–614.Google Scholar
2. Wells, CL, Podzorski, RP, Peterson, PK, et al: Incidence of trimethoprim-sulfa-methoxazole-resistant Enterobacteriaceae among transplant recipients. J Infect Dis 1984;150:699–706.CrossRefGoogle ScholarPubMed
3. Tancrede, CH, Andremont, AO, Bacterial translocation and gram-negative bacteremia in patients with hematological malignancies, J Infect Dis 1985;152:99–103.Google Scholar
4. O'Brien, TF Acar, JF, Altman, G, et al: Laboratory surveillance of synergy between and resistance to trimethoprim and sulfonamides. Rev Infect Dis 1982;4:351–357.CrossRefGoogle ScholarPubMed
5. Beschorner, WE, Yardley, JH, Tutschka, PJ, et al: Deficiency of intestinal immunity with graft-vs-host disease in humans. J Infect Dis 1981;144:38–46.Google Scholar
6. Guiot, HFL, van der Meer, JWM, van Furth, R, Selective antimicrobial modulation of human microbial flora: Infection prevention in patients with decreased host defense mechanisms by selective elimination of potentially pathogenic bacteria. J Infect Dis 1981;143:644–654.Google Scholar
7. Hargadon, MT, Young, VM, Schimpft, SC, et al: Selective suppression of alimentary tract microbial Hora as prophylaxis during granulocytopenia. Antimicrob Agents Chemother 1981;20:620–624.Google Scholar
8. van der Waaij, DD, Berghuis-DeVries, JM, Lekkerkerk-van der Wees, JEC, Colonization resistance of the digestive tract of mice during systemic antibiotic treatment. J Hygiene 1972;70:605–610.CrossRefGoogle ScholarPubMed
9. Pizzo, PA, Robichaud, KJ, Edwards, BK, et al: Oral antibiotic prophylaxis in patients with cancer: A double-blind randomized placebo-controlled trial. J Pediatr 1983;102:125–133.Google Scholar