Hostname: page-component-586b7cd67f-2plfb Total loading time: 0 Render date: 2024-11-29T08:51:09.286Z Has data issue: false hasContentIssue false

Epidemiology of Methicillin-Resistant Staphylococcus aureus Bacteremia in Gaborone, Botswana

Published online by Cambridge University Press:  02 January 2015

Sarah M. Wood*
Affiliation:
Division of General Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA
Samir S. Shah
Affiliation:
Division of General Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA Division of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, PA Center for Clinical Epidemiology and Biostatistics, Philadelphia, PA
Margaret Bafana
Affiliation:
Botswana National Health Laboratory, Gaborone, Botswana
Adam J. Ratner
Affiliation:
Departments of Pediatrics and Microbiology, Columbia University, New York, NY
Peter A. Meaney
Affiliation:
Division of Anesthesia and Critical Care, Children's Hospital of Philadelphia, Philadelphia, PA
Kolaatamo C. S. Malefho
Affiliation:
Princess Marina Hospital, Gaborone, Botswana
Andrew P. Steenhoff
Affiliation:
Division of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, PA Center for Clinical Epidemiology and Biostatistics, Philadelphia, PA Center of AIDS Research, Philadelphia, PA Princess Marina Hospital, Gaborone, Botswana
*
Pediatric Residency Program, Children's Hospital of Philadelphia, 34th and Civic Center Boulevard, Room 9NW55 Main, Philadelphia, PA 19104 ([email protected])

Abstract

This cross-sectional study at a tertiary-care hospital in Botswana from 2000 to 2007 was performed to determine the epidemiologic characteristics of Staphylococcus aureus bacteremia. We identified a high prevalence (11.2% of bacteremia cases) of methicillin-resistant S. aureus (MRSA) bacteremia. MRSA isolates had higher proportions of resistance to commonly used antimicrobials than did methicillin-susceptible isolates, emphasizing the need to revise empiric prescribing practices in Botswana.

Type
Concise Communications
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2009

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Perovic, O, Koornhof, H, Black, V, Moodley, I, Duse, A, Galpin, J. Staphylococcus aureus bacteraemia at two academic hospitals in Johannesburg. S Afr Med J 2006;96(8):714717.Google ScholarPubMed
2.Shittu, AO, Lin, J. Antimicrobial susceptibility patterns and characterization of clinical isolates of Staphylococcus aureus in KwaZulu-Natal province, South Africa. BMC Infect Dis 2006;6:125.Google Scholar
3.Meremikwu, MM, Nwachukwu, CE, Asuquo, AE, Okebe, JU, Utsalo, SJ. Bacterial isolates from blood cultures of children with suspected septicaemia in Calabar, Nigeria. BMC Infect Dis 2005;5:110.CrossRefGoogle ScholarPubMed
4.Blomberg, B, Manji, KP, Urassa, WK, et al.Antimicrobial resistance predicts death in Tanzanian children with bloodstream infections: a prospective cohort study. BMC Infect Dis 2007;7:43.CrossRefGoogle ScholarPubMed
5.Bachou, H, Tylleskar, T, Kaddu-Mulindwa, DH, Tumwine, JK. Bacteraemia among severely malnourished children infected and uninfected with the human immunodeficiency virus-1 in Kampala, Uganda. BMC Infect Dis 2006;6:160.Google Scholar
6.Archibald, LK, Reiler, LB. Clinical microbiology in developing countries. Emerg Infect Dis 2001;7:302305.Google Scholar
7.National AIDS Coordinating Agency. Botswana AIDS Impact Survey II: Popular Report. Gabarone, Botswana: National AIDS Coordinating Agency; 2005.Google Scholar
8.Cosgrove, SE, Qi, Y, Kaye, KS, Harbarth, S, Karchmer, AW, Carmeli, Y. The impact of methicillin resistance in Staphylococcus aureus bacteremia on patient outcomes: mortality, length of stay, and hospital charges. Infect Control Hosp Epidemiol 2005;26:166174.Google Scholar
9.Cordova, SP, Heath, CH, McGechie, DB, Keil, AD, Beers, MY, Riley, TV. Methicillin-resistant Staphylococcus aureus bacteraemia in Western Australian teaching hospitals, 1997-1999: risk factors, outcomes and implications for management. J Hosp Infect 2004;56:2228.CrossRefGoogle ScholarPubMed