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Epidemiology of Infection and Colonization With Vancomycin-Resistant Enterococci and Frequency of Cocolonization With Methicillin-Resistant Staphylococcus aureus in Children

Published online by Cambridge University Press:  02 January 2015

Lacey Benson
Affiliation:
Case Western Medical School, Cleveland, Ohio
Bruce Sprague
Affiliation:
Center for Health Services and Community Research, Children's National Medical Center, Children's National Medical Center, The George Washington University School of Medicine, Washington, DC
Joseph Campos
Affiliation:
Departments of Pediatrics, The George Washington University School of Medicine, Children's National Medical Center, Washington, DC Pathology, The George Washington University School of Medicine, Children's National Medical Center, Washington, DC Microbiology-Tropical Medicine, The George Washington University School of Medicine, Children's National Medical Center, Washington, DC Department of Laboratory Medicine, Children's National Medical Center, The George Washington University School of Medicine, Washington, DC
Nalini Singh*
Affiliation:
Departments of Pediatrics, The George Washington University School of Medicine, Children's National Medical Center, Washington, DC Division of Infectious Diseases, Children's National Medical Center, The George Washington University School of Medicine, Washington, DC
*
Departments of Pediatrics, Epidemiology, and Global Health, The George Washington University Schools of Medicine and Public Health, 111 Michigan Avenue NW, Washington, DC 20010 ([email protected])

Abstract

We report the descriptive and molecular epidemiology of vancomycin-resistant enterococci (VRE) infection and colonization and cocolonization with methicillin-resistant Staphylococcus aureus (MRSA) in children. Interunit and intraunit spread of VRE was detected, and 8 cases of VRE-MRSA cocolonization were identified. Seven of these cases were identified only via active surveillance, because clinical evidence of VRE colonization was absent.

Type
Concise Communications
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2007

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References

1.Clinical and Laboratory Standards Institute (CLSI). Performance Standards for Antimicrobial Susceptibility Testing. Wayne, PA: CLSI; 2005. CLSI documentM100S15.Google Scholar
2.Nambiar, S, Herwaldt, LA, Singh, N. Outbreak of invasive disease caused by methicillin-resistant Staphylococcus aureus in neonates and prevalence in the neonatal intensive care unit. Pediatr Crit Care Med 2003;4:220226.Google Scholar
3.Mlynarczyk, A, Mlynarczyk, G, Luczak, M. Conjugative transfer of gly-copeptide and macrolide resistant genes among Enterococci and from Enterococcus faecalis to Staphylococcus aureus. Med Dosw Mikrobiol 2002;54:2138.Google Scholar
4.Weigel, L, Clewell, DB, Gill, SR, et al.Genetic analysis of a high-level vancomycin-resistant isolate of Staphylococcus aureus. Science 2003;302:1488.Google Scholar
5.Jenkins, SG. Trends associated with Glycopeptides: heteroresistance, tolerance and lack of detection. Clin Updates Infect Dis 2006;8:16. Available at: http://www.nfid.org/pdf/id_archive/glycopeptide_trends.pdf. Accessed May 13, 2007.Google Scholar
6.Singh, N, Leger, MM, Campbell, J, Short, B, Campos, JM. Control of vancomycin-resistant enterococci in the neonatal intensive care unit. Infect Control Hosp Epidemiol 2005;26:646649.CrossRefGoogle ScholarPubMed
7.Healy, M, Huong, J, Bittner, T, et al.Microbial DNA typing by automated repetitive-sequence-based PCR. J Clin Microbiol 2005;43:199207.Google Scholar
8.Sherer, C, Sprague, BM, Campos, JM, et al.Characterizing vancomycin-resistant enterococci in neonatal intensive care. Emerg Infect Dis 2005;11:14701472.Google Scholar
9.Furuno, J, Perencevich, EN, Johnson, JA, et al.Methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci co-colonization. Emerg Infect Dis 2005;11:15391544.Google Scholar
10.Nambiar, S, Singh, N. Co-infection With Methicillin Resistant Staphylococcus aureus and Vancomycin Resistant Enterococcus in Children. Santiago, Chile: World Society for Pediatric Infectious Disease; 2002.Google Scholar
11.Bootsma, MC, Diekmann, O, Bonten, MJ. Controlling methicillin-resistant Staphylococcus aureus: quantifying the effects of interventions and rapid diagnostic testing. Proc Natl Acad Sci USA 2006;103:56205625.Google Scholar