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Effect of Zidovudine Postexposure Prophylaxis on the Development of HIV-Specific Cytotoxic T-Lymphocyte Responses in HIV-Exposed Healthcare Workers

Published online by Cambridge University Press:  02 January 2015

Ronnie D'Amico ,
Ligia A. Pinto ,
Peter Meyer ,
Alan L. Landay ,
Alan A. Harris ,
Mario Clerici ,
Jay A. Berzofsky ,
Gene M. Shearer  and
Harold A. Kessler
Ronnie D'Amico
Affiliation:
Department of Medicine, Rush Medical College, Chicago, Illinos
Ligia A. Pinto
Affiliation:
National Cancer Institute, National Institutes of Health, Bethesda, Maryland
Peter Meyer
Affiliation:
Department of Preventive Medicine, Rush Medical College, Chicago, Illinos
Alan L. Landay
Affiliation:
Department of Medicine, Rush Medical College, Chicago, Illinos Department of Immunology/Microbiology, Rush Medical College, Chicago, Illinos
Alan A. Harris
Affiliation:
Department of Medicine, Rush Medical College, Chicago, Illinos
Mario Clerici
Affiliation:
Catteredra di Immunologia, Universita degli Studi di Milano, Milano, Italy
Jay A. Berzofsky
Affiliation:
National Cancer Institute, National Institutes of Health, Bethesda, Maryland
Gene M. Shearer
Affiliation:
National Cancer Institute, National Institutes of Health, Bethesda, Maryland
Harold A. Kessler*
Affiliation:
Department of Medicine, Rush Medical College, Chicago, Illinos Department of Immunology/Microbiology, Rush Medical College, Chicago, Illinos
*
Section of Infectious Diseases, Rush-Presbyterian-St Luke's Medical Center, 600 South Paulina, Ste 143 AAF, Chicago, IL 60612
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Abstract

We evaluated the effects of zidovudine postexposure prophylaxis (PEP) on the development of human immunodeficiency virus (HIV) envelope-specific cytotoxic T-lymphocyte responses in 20 healthcare workers with occupational exposures to HIV. Seven healthcare workers were treated with zidovudine PER Only 1 of 7 treated, versus 6 of 13 not treated, developed an HIV envelope-specific cytotoxic T-lymphocyte response. These data suggest that zidovudine abrogated HIV-specific cytotoxic T-lymphocyte responses. HIV-specific cytotoxic T-lymphocyte responses may be useful as a surrogate marker of HIV replication in the evaluation of new regimens for PEP of occupational HIV exposures.

Type
Concise Communications
Information
Infection Control & Hospital Epidemiology , Volume 20 , Issue 6 , June 1999 , pp. 428 - 430
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1999

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