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Comparison of the Duration of Antimicrobial Activity of 2 Different Antimicrobial Central Venous Catheters

Published online by Cambridge University Press:  02 January 2015

Theofilos Matheos
Affiliation:
Department of Anesthesiology, University of Massachusetts Medical School, Worcester, Massachusetts
J. Matthias Walz
Affiliation:
Department of Anesthesiology, University of Massachusetts Medical School, Worcester, Massachusetts Department of Surgery, University of Massachusetts Medical School, Worcester, Massachusetts.
Janice P. Adams
Affiliation:
Department of Anesthesiology, University of Massachusetts Medical School, Worcester, Massachusetts
Karen Johnson
Affiliation:
Department of Anesthesiology, University of Massachusetts Medical School, Worcester, Massachusetts
Karen Longtine
Affiliation:
Department of Anesthesiology, University of Massachusetts Medical School, Worcester, Massachusetts
Jaclyn Longtine
Affiliation:
Department of Anesthesiology, University of Massachusetts Medical School, Worcester, Massachusetts
Melissa O'Neill
Affiliation:
Department of Anesthesiology, University of Massachusetts Medical School, Worcester, Massachusetts
Stephen O. Heard*
Affiliation:
Department of Anesthesiology, University of Massachusetts Medical School, Worcester, Massachusetts Department of Surgery, University of Massachusetts Medical School, Worcester, Massachusetts.
*
Department of Anesthesiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655 ([email protected])

Extract

We compared the duration of antimicrobial effectiveness of 2 different antimicrobial catheters. The baseline activity of minocycline-rifampin catheters was greater than that of silver-platinum-carbon catheters against Staphylococcus aureus, Staphylococcus epidermidis, and Enterococcus faecalis. The antimicrobial activity of the minocycline-rifampin catheters against these pathogens persisted for up to 12 days, while that of the silver-platinum-carbon catheters was depleted by day 10 (P< .05).

Type
Concise Communications
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2010

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References

1.Mermel, LA. Prevention of intravascular catheter–related infections (published correction appears in Ann Intern Med 2000;133:395). Ann Intern Med 2000;132:391402.CrossRefGoogle Scholar
2.Darouiche, RO, Raad, II, Heard, SO, et al.A comparison of two anti-microbial-impregnated central venous catheters. Catheter Study Group. N Engl J Med 1999;340:18.Google Scholar
3.Maki, DG, Stolz, SM, Wheeler, S, Mermel, LA. Prevention of central venous catheter–related bloodstream infection by use of an antiseptic-impregnated catheter: a randomized, controlled trial. Ann Intern Med 1997;127:257266.CrossRefGoogle ScholarPubMed
4.Fraenkel, D, Rickard, C, Thomas, P, Faoagali, J, George, N, Ware, R. A prospective, randomized trial of rifampicin-minocycline-coated and silver-platinum-carbon-impregnated central venous catheters. Crit Care Med 2006;34:668675.CrossRefGoogle ScholarPubMed
5.Marik, PE, Abraham, G, Careau, P, Varon, J, Fromm, RE JrThe ex vivo antimicrobial activity and colonization rate of two antimicrobial-bonded central venous catheters. Crit Care Med 1999;27:11281131.Google Scholar
6.Bassetti, S, Hu, J, D'Agostino, RB JrSherertz, RJ. In vitro zones of inhibition of coated vascular catheters predict efficacy in preventing catheter infection with Staphylococcus aureus in vivo. Eur J Clin Microbiol Infect Dis 2000;19:612617.CrossRefGoogle ScholarPubMed
7.Raad, I, Darouiche, R, Hachem, R, Mansouri, M, Bodey, GP. The broad-spectrum activity and efficacy of catheters coated with minocycline and rifampin. J Infect Dis 1996;173:418424.Google Scholar
8.Hanna, H, Bahna, P, Reitzel, R, et al.Comparative in vitro efficacies and antimicrobial durabilities of novel antimicrobial central venous catheters. Antimicrob Agents Chemother 2006;50:32833288.Google Scholar
9.Yorganci, K, Krepel, C, Weigelt, JA, Edmiston, CE. In vitro evaluation of the antibacterial activity of three different central venous catheters against gram-positive bacteria. Eur J Clin Microbiol Infect Dis 2002;21:379384.Google Scholar
10.Quinn, MT, Milder, FL. The Science of Oligon. http://ht.edwards.com/resourcegallery/products/centralvenousaccess/pdfs/scienceofoligon1124.pdf. Irvine, CA: Edwards Lifesciences; 2002. Accessed August 25, 2009.Google Scholar