Hostname: page-component-78c5997874-lj6df Total loading time: 0 Render date: 2024-11-17T15:04:41.452Z Has data issue: false hasContentIssue false

Comparison of the Burdens of Hospital-Onset, Healthcare Facility-Associated Clostridium difficile Infection and of Healthcare-Associated Infection due to Methicillin-Resistant Staphylococcus aureus in Community Hospitals

Published online by Cambridge University Press:  02 January 2015

Becky A. Miller*
Affiliation:
Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina
Luke F. Chen
Affiliation:
Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina
Daniel J. Sexton
Affiliation:
Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina
Deverick J. Anderson
Affiliation:
Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina
*
Box 102359, Duke University Medical Center, Durham, NC 27710 ([email protected])

Abstract

We sought to determine the burden of nosocomial Clostridium difficile infection in comparison to other healthcare-associated infections (HAIs) in community hospitals participating in an infection control network. Our data suggest that C. difficilehas replaced MRSA as the most common etiology of HAI in community hospitals in the southeastern United States.

Type
Concise Communication
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2011

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Dallal, RM, Harbrecht, BG, Boujoukas, AJ, et al. Fulminant Clostridium difficile: an underappreciated and increasing cause of death and complications. Ann Surg 2002;235:363372.Google Scholar
2. McDonald, LC, Owings, M, Jernigan, DB. Clostridium difficile infection in patients discharged from US short-stay hospitals, 1996-2003. Emerg Infect Dis 2006;12:409415.Google Scholar
3. Musher, DM, Aslam, S, Logan, N, et al. Relatively poor outcome after treatment of Clostridium difficile colitis with metronidazole. Clin Infect Dis 2005;40:15861590.Google Scholar
4. Pepin, J, Valiquette, L, Alary, ME, et al. Clostridium difficile-associated diarrhea in a region of Quebec from 1991 to 2003: a changing pattern of disease severity. CMAJ 2004;171:466472.Google Scholar
5. Dubberke, ER, Butler, AM, Yokoe, DS, et al. Multicenter study of surveillance for hospital-onset Clostridium difficile infection by the use of ICD-9-CM diagnosis codes. Infect Control Hosp Epidemiol 2010;31:262268.10.1086/650447Google Scholar
6. Anderson, DJ, Sexton, DJ, Kanafani, ZA, Auten, G, Kaye, KS. Severe surgical site infection in community hospitals: epidemiology, key procedures, and the changing prevalence of methicillin-resistant Staphylococcus aureus . Infect Control Hosp Epidemiol 2007;28:10471053.Google Scholar
7. Horan, TC, Andrus, M, Dudeck, MA. CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control 2008;36:309332.Google Scholar
8. McDonald, LC, Coignard, B, Dubberke, E, Song, X, Horan, T, Kutty, PK. Recommendations for surveillance of Clostridium difficile-associated disease. Infect Control Hosp Epidemiol 2007;28:140145.10.1086/511798Google Scholar
9. Kaye, KS, Engemann, JJ, Fulmer, EM, Clark, CC, Noga, EM, Sexton, DJ. Favorable impact of an infection control network on nosocomial infection rates in community hospitals. Infect Control Hosp Epidemiol 2006;27:228232.Google Scholar
10. Kaye, KS, Sloane, R, Sexton, DJ, Schmader, KA. Risk factors for surgical site infections in older people. J Am Geriatr Soc 2006;54:391396.Google Scholar
11. McDonald, LC, Killgore, GE, Thompson, A, et al. An epidemic, toxin gene-variant strain of Clostridium difficile . N Engl J Med 2005;353:24332441.Google Scholar
12. Loo, VG, Libman, MD, Miller, MA, et al. Clostridium difficile, a formidable foe. CMAJ 2004;171:4748.Google Scholar
13. Loo, VG, Poirier, L, Miller, MA, et al. A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality. N Engl J Med 2005;353:24422449.Google Scholar
14. Birgand, G, Miliani, K, Carbonne, A, Astagneau, P. Is high consumption of antibiotics associated with Clostridium difficile polymerase chain reaction-ribotype 027 infections in France? Infect Control Hosp Epidemiol 2010;31:302305.Google Scholar
15. O'Connor, JR, Johnson, S, Gerding, DN. Clostridium difficile infection caused by the epidemic BI/NAP1/027 strain. Gastroenterology 2009;136:19131924.Google Scholar
16. Kallen, AJ, Mu, Y, Bulens, S, et al. Health care-associated invasive MRSA infections, 2005-2008. JAMA 2010;304:641647.Google Scholar
17. Anderson, DJ, Sexton, DJ. Whither infection control in community hospitals? musings about the near future. Infect Control Hosp Epidemiol 2008;29:10711073.Google Scholar