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Beta-Lactamase Inhibitors: Another Approach to Overcoming Antimicrobial Resistance

Published online by Cambridge University Press:  02 January 2015

Richard H. Parker  and
Mark Eggleston
Richard H. Parker
Affiliation:
Howard University School of Medicine, College of Pharmacy & Pharmacal Sciences, Howard University; and the Antimicrobial Agent Research Laboratory, Providence Hospital, Washington, DC
Mark Eggleston*
Affiliation:
Howard University School of Medicine, College of Pharmacy & Pharmacal Sciences, Howard University; and the Antimicrobial Agent Research Laboratory, Providence Hospital, Washington, DC
*
PO Box 115, Woodbridge, VA 22193
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Extract

Resistance of most clinical pathogens to beta-lactam antimicrobial agents is currently primarily mediated by the microorganisms' ability to product beta-lactamases. There are a variety of beta-lactamases which are primarily differentiated by whether they are plasmid- or chromosome-mediated and by their substrate and inhibition profiles. The most common group of beta-lactamases produced by clinical isolates are the plasmid-mediated TEM enzymes (Richmond-Sykes type III a) which exist in many Enterobacteriaceae, Hemophilus influenzae, and Neisseria species. Development of new beta-lactam antimicrobial agents during the past decades has resulted in a number of drugs with increased, albeit not total, resistance to beta-lactamases. Another approach has been the development of beta-lactamase inhibitors that can be used with a beta-lactam drug to overcome the resistance created by the beta-lactamase.

Type
Special Sections
Information
Infection Control & Hospital Epidemiology , Volume 8 , Issue 1 , January 1987 , pp. 36 - 40
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1987

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