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Antimicrobial-Resistant Pathogens Associated With Healthcare-Associated Infections: Annual Summary of Data Reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006–2007

Published online by Cambridge University Press:  02 January 2015

Alicia I. Hidron ,
Jonathan R. Edwards ,
Jean Patel ,
Teresa C. Horan ,
Dawn M. Sievert ,
Daniel A. Pollock ,
Scott K. Fridkin  and
National Healthcare Safety Network Team and Participating National Healthcare Safety Network Facilities
Alicia I. Hidron
Affiliation:
Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia
Jonathan R. Edwards
Affiliation:
Centers for Disease Control and Prevention, Division of Healthcare Quality Promotion, Atlanta, Georgia
Jean Patel
Affiliation:
Centers for Disease Control and Prevention, Division of Healthcare Quality Promotion, Atlanta, Georgia
Teresa C. Horan
Affiliation:
Centers for Disease Control and Prevention, Division of Healthcare Quality Promotion, Atlanta, Georgia
Dawn M. Sievert*
Affiliation:
Centers for Disease Control and Prevention, Division of Healthcare Quality Promotion, Atlanta, Georgia
Daniel A. Pollock
Affiliation:
Centers for Disease Control and Prevention, Division of Healthcare Quality Promotion, Atlanta, Georgia
Scott K. Fridkin
Affiliation:
Centers for Disease Control and Prevention, Division of Healthcare Quality Promotion, Atlanta, Georgia
*
Surveillance Branch, Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, 1600 Clifton Road, NE Mailstop A-24, Atlanta, GA 30333 ([email protected])
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Abstract

Objective.

To describe the frequency of selected antimicrobial resistance patterns among pathogens causing device-associated and procedure-associated healthcare-associated infections (HAIs) reported by hospitals in the National Healthcare Safety Network (NHSN).

Methods.

Data are included on HAIs (ie, central line-associated bloodstream infections, catheter-associated urinary tract infections, ventilator-associated pneumonia, and surgical site infections) reported to the Patient Safety Component of the NHSN between January 2006 and October 2007. The results of antimicrobial susceptibility testing of up to 3 pathogenic isolates per HAI by a hospital were evaluated to define antimicrobial-resistance in the pathogenic isolates. The pooled mean proportions of pathogenic isolates interpreted as resistant to selected antimicrobial agents were calculated by type of HAI and overall. The incidence rates of specific device-associated infections were calculated for selected antimicrobial-resistant pathogens according to type of patient care area; the variability in the reported rates is described.

Results.

Overall, 463 hospitals reported 1 or more HAIs: 412 (89%) were general acute care hospitals, and 309 (67%) had 200-1,000 beds. There were 28,502 HAIs reported among 25,384 patients. The 10 most common pathogens (accounting for 84% of any HAIs) were coagulase-negative staphylococci (15%), Staphylococcus aureus (15%), Enterococcus species (12%), Candida species (11%), Escherichia coli (10%), Pseudomonas aeruginosa (8%), Klebsiella pneumoniae (6%), Enterobacter species (5%), Acinetobacter baumannii (3%), and Klebsiella oxytoca (2%). The pooled mean proportion of pathogenic isolates resistant to antimicrobial agents varied significantly across types of HAI for some pathogen-antimicrobial combinations. As many as 16% of all HAIs were associated with the following multidrug-resistant pathogens: methicillin-resistant S. aureus (8% of HAIs), vancomycin-resistant Enterococcus faecium (4%), carbapenem-resistant P. aeruginosa (2%), extended-spectrum cephalosporin-resistant K. pneumoniae (1%), extended-spectrum cephalosporin-resistant E. coli (0.5%), and carbapenem-resistant A. baumannii, K. pneumoniae, K. oxytoca, and E. coli (0.5%). Nationwide, the majority of units reported no HAIs due to these antimicrobial-resistant pathogens.

Type
NHSN Annual Update
Information
Infection Control & Hospital Epidemiology , Volume 29 , Issue 11 , November 2008 , pp. 996 - 1011
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2008

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