After reviewing the article by Johnson et al. (2010), I began to ask myself and other industrial and organizational (I-O) psychologists what interest groups might be impacted by a Society for Industrial and Organizational Psychology (SIOP)-sponsored synthetic validity database and its resulting mechanical behavior and performance predictions. Who are the various stakeholders and what might be the positive or negative outcomes caused by this “disruptive technology” that could cause “creative destruction” in the I-O psychology profession? Among the consumers and producers of performance prediction, who might gain and who might be creatively destroyed? From these questions and the subsequent conversations, I identified the following categories and possibilities, but I am sure there are others that I have not anticipated.