In this paper, I undertake an exploration of the similarities I find between the epistemological projects of John Dewey and Evelyn Fox Keller. These similarities, I suggest, warrant considering Dewey and Keller to share membership in an epistemological tradition, a tradition I label the “Coresponsible Option.” In my examination, I focus on Dewey's and Keller's ontological assertion that we live in a world that is an inextricable mixture of certainty and chance, and on their resultant conception of inquiry as a communal relationship.