Hostname: page-component-586b7cd67f-tf8b9 Total loading time: 0 Render date: 2024-11-25T04:09:14.487Z Has data issue: false hasContentIssue false
  • English
  • Français

Can Clinical Research Be Both Ethical and Scientific? A Commentary inspired by Rosser and Marquis

Published online by Cambridge University Press:  25 March 2020

Helen Bequaert Holmes
Get access Rights & Permissions [Opens in a new window]

Abstract

Problems with clinical research that create conflicts between doctors’ therapeutic and research obligations may be fueled by a rigid view of science as determiner of truth, a heavy reliance on statistics, and certain features of randomized clinical trials. 1 suggest some creative, feminist approaches to such research and explore ways to provide choice for patients and to use values in directing both therapy and science — to enhance the effectiveness of each.

Type
Research Article
Information
Hypatia , Volume 4 , Issue 2: Special Issue: Feminist Ethics and Medicine , Summer 1989 , pp. 156 - 168
Copyright
Copyright © 1989 by Hypatia, Inc.

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Andrews, Mason C, Muasher, Suheil J., Levy, Donald L., Jones, Howard W. Jr, Garcia, Jairo E., Rosenwaks, Zev, Jones, Georgeanna S., and Acosta, Anibal A. 1986. An analysis of the obstetric outcome of 125 consecutive pregnancies conceived in vitro and resulting in 100 deliveries. American Journal of Obstetrics and Gynecology 154:848–854.CrossRefGoogle ScholarPubMed
Byar, David P., Simon, Richard M., Friedewald, William T., Schlesselman, James J., DeMets, David L., Ellenberg, Jonas H., Gail, Mitchell H. and Ware, James H. 1976. Randomized clinical trials: Perspectives on some recent ideas. New England Journal of Medicine 295:74–80.CrossRefGoogle ScholarPubMed
Chalmers, T.C. 1981. The clinical trial. Milbank Memorial Fund Quarterly 59:325–339.Google ScholarPubMed
Conn, Harold O. 1974‐ Therapeutic portacaval anastomosis: To shunt or not to shunt. Gastroenterology 67:1065–1073.CrossRefGoogle ScholarPubMed
Gordon, Robert S., and Fletcher, John C. 1983. Can strict randomization be ethically acceptable? Clinical Research 31 (1):23–25.Google ScholarPubMed
Kopelmann, Loretta. 1983. Randomized clinical trials, consent and the therapeutic relationship. Clinical Research 31 (1):1–11.Google Scholar
Lebacqz, Karen. 1983. Justice, choice, and the language of research. Clinical Research 31, (1):26–27.Google Scholar
Levine, Robert J. 1985. The use of placebos in randomized clinical trials. IRB 7 (2):1–4.CrossRefGoogle ScholarPubMed
Levine, Robert J. 1988. Ethics and regulation of clinical research. New Haven: Yale University Press, 2nd ed.Google ScholarPubMed
Loftus, Elizabeth F., and Fries, James F. 1979. Informed consent may be hazardous to health. Science 204:11.CrossRefGoogle Scholar
Longino, Helen E. 1987. Can there be a feminist science? Hypatia 2 (3):51–64.CrossRefGoogle Scholar
Marquis, Don. 1989. An ethical problem concerning recent therapeutic research on breast cancer. Hypatia 4 (2): 140–155.10.1111/j.1527-2001.1989.tb00578.xCrossRefGoogle ScholarPubMed
McBride, Judy. 1988. Asian children may quell nutritional controversy. Agricultural Research February: 11.Google Scholar
NOVA. 1988, October 25. Do scientists cheat? Boston: WGBS.Google Scholar
Ratcliffe, John W., and Gonzalez‐del‐Valle, Amalia. 1988. Rigor in health‐related research: Toward an expanded conceptualization. International Journal of Health Services 18 (3):361–392.CrossRefGoogle ScholarPubMed
Rosner, Fred. 1987. The ethics of randomized clinical trials. The American Journal of Medicine 82:283–290.CrossRefGoogle ScholarPubMed
Rosser, Sue V. 1989. Re‐visioning clinical research — gender and the ethics of experimental design. Hypatia 4 (2): 125–139.CrossRefGoogle ScholarPubMed
Sherwin, Susan. 1989. Medical and feminist ethics: Two different approaches to contextual ethics. Hypatia 4 (2): 57–72.CrossRefGoogle ScholarPubMed
Silverman, William A. 1985. Human experimentation: A guided step into the unknown. Oxford: Oxford University Press.Google Scholar
Veatch, Robert. 1983. Justice and research design: The case for a semi‐randomization clinical trial. Clinical Research 31 (1):12–22.Google ScholarPubMed
Veatch, Robert M. 1987a. The patient as partner: A theory of human‐experimentation ethics. Bloomington: Indiana University Press.Google Scholar
Veatch, Robert M. 1987b. Emphasis on values prompting a change in medical practice. Kennedy Institute of Ethics Newsletter 1 (9):1–2.Google Scholar
Veatch, Robert M. 1988. Should I enroll in a randomized clinical trial? A critical commentary. 1KB 10 (5):7–8.Google Scholar
Weinstein, Milton C. 1974. Allocation of subjects in medical experiments. New England journal of Medicine 291:1278–1285.CrossRefGoogle ScholarPubMed