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The XO and OY chromosome constitutions in the mouse

Published online by Cambridge University Press:  14 April 2009

T. Morris
T. Morris
Affiliation:
Medical Research Council, Radiobiological Research Unit, Harwell, Didcot, Berks.

Extract

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A study was made of reproductive performance and embryonic mortality in XO and XX females. In the stock used, the mean litter size of XO females (4·46) was greatly below that of XX ones (8·17). One series of pregnant females of both karyotypes was dissected after 15 days' gestation, and another series after 3½days' gestation. In the former, there was a significantly greater amount of embryonic mortality in XO females both before implantation and at the small and large mole stages. By far the greater amount occurred before implantation. The data from dissections after 3½ days' gestation concerned pre-implantation embryos, since normal embryos at this point are at the late morula or early blastocyst stage. The embryos from XO females contained a large group of obviously and characteristically abnormal ones; they comprised 60/280 of the embryos from XO females, compared with 4/189 of the XX ones. They appeared to have developed abnormally from a very early stage, probably the two-cell stage, and were considered to represent the missing OY class of zygotes. In addition, it was concluded that there was probably an abnormally low segregation of nullo-X gametes from XO females.

Type
Research Article
Information
Genetics Research , Volume 12 , Issue 2 , October 1968 , pp. 125 - 137
Copyright
Copyright © Cambridge University Press 1968

References

REFERENCES

Bowman, J. C. & Roberts, R. C. (1958). Embryonic mortality in relation to ovulation rate in the house mouse. J. exp. Biol. 35, 138–143.CrossRefGoogle Scholar
Garr, D. H. (1967). Chromosome anomalies as a cause of spontaneous abortion. Am. J. Obst. Gynec. 97, 283–293.Google Scholar
Cattanach, B. M. (1962). XO mice. Genet. Res., Camb. 3, 487–490.CrossRefGoogle Scholar
Flax, M. H. (1953). Ph.D. Thesis, Columbia (as reported by Mintz (1965)).Google Scholar
Jacobs, P. A. (1966). Abnormalities of the seX-chromosomes in man. Advances in Reproductive Physiology, Ch. 3, pp. 61–91.Google ScholarPubMed
Jacobs, P. A., Brunton, M., Melville, M. M., Brittain, R. P. & McClemont, W. F. (1965). Aggressive behaviour, mental subnormality and the XXY male. Nature, Lond. 208, 1351—1352.CrossRefGoogle Scholar
Kerr, M. G. (1966). Chromosome anomalies and pregnancy waste. J. Reprod. Fert. 12, 421.Google Scholar
Lindsten, J., Bowen, P., Lee, C. S. N., McKusick, V. A., Polani, P. E., Wingate, M., Edwards, J. H., Hamper, J., Tippett, P., Sanger, R. & Race, R. R. (1963). Source of the X in XO females: The evidence of Xg. Lancet 1, 558–559.CrossRefGoogle ScholarPubMed
Lyon, M. F. (1961). Gene action in the X-chromosome of the mouse. Nature, Lond. 190, 372–373.CrossRefGoogle ScholarPubMed
MacLean, N., Harndean, D. G., Court Brown, W. M., Bond, J. & Mantle, D. J. (1964). Sex-chromosome abnormalities in new born babies. Lancet, 1, 286.Google Scholar
Mintz, B. (1965). Preimplantation stages of pregnancy. (Ciba Symposium), pp. 145–155. Nucleic acid and protein synthesis in the developing mouse embryos.Google Scholar
Nowakowski, H., Lenz, W. & Parada, J., (1959). Diskrepanz zwischen Chromatinbefund und genetischen Geschlect bein Klinefelter-Syndrom. Acta endocr., Copenhagen 30, 296Google Scholar
Race, R. R., (1965). Identification of the origin of the X chromosome(s) in sex chromosome aneuploidy. Can. J. Genet. Cytol. 7, 214–222.CrossRefGoogle ScholarPubMed
Russell, L. B. (1961). Genetics of mammalian sex chromosomes. Science 133, 1795–1803.CrossRefGoogle ScholarPubMed
Russell, L. B. & Saylors, C. L. (1963). The relative sensitivity of various germ-cell stages of the mouse to radiation-induced non-disjunction, chromosome losses and deficiencies. Repair from Genetic Radiation, pp. 313–340. (Ed. Sobels, ) Pergamon.Google Scholar
Welshons, W. J. & Russell, L. B. (1959). The Y chromosome as the bearer of male determining factors in the mouse. Proc. Nat. Acad. Sci., Wash. 45, 560–566.CrossRefGoogle Scholar