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X-chromosome segregation, maternal age and aneuploidy in the XO mouse

Published online by Cambridge University Press:  14 April 2009

J. D. Brook
J. D. Brook
Affiliation:
MRC Clinical and Population Cytogenetics Unit, Western General Hospital, Crewe Road South, Edinburgh, EH4 2XU
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Summary

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Cytogenetic studies have ascertained that the segregation of the X-chromosome, during the first meiotic division of the oocyte in XO mice, occurs at random, contrary to the finding of some earlier authors. The ratio of nullo-X to X-bearing oocytes at ovulation does not change with maternal age. The usefulness of the XO mouse as a model for aneuploidy production in women (Lyon & Hawker, 1973) is discussed.

Type
Research Article
Information
Genetics Research , Volume 41 , Issue 1 , February 1983 , pp. 85 - 95
Copyright
Copyright © Cambridge University Press 1983

References

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