Hostname: page-component-78c5997874-lj6df Total loading time: 0 Render date: 2024-11-05T11:48:24.148Z Has data issue: false hasContentIssue false
  • English
  • Français

Variations in resistance to three antibiotics among some single-step mutants to Chloramphenicol resistance in a strain of Escherichia coli K 12

Published online by Cambridge University Press:  14 April 2009

E. C. R. Reeve  and
J. O. Bishop
E. C. R. Reeve
Affiliation:
Institute of Animal Genetics, Edinburgh 9
J. O. Bishop
Affiliation:
Institute of Animal Genetics, Edinburgh 9
Rights & Permissions [Opens in a new window]

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Chloramphenicol (CM), Aureomycin (AM) and Puromycin (PM) induce RNA synthesis in RC-stringent Escherichia coli starved of a required amino acid. This fact has been used to develop a method for comparing the levels of resistance of single-step CM-r mutants to the three antibiotics. Three levels of resistance to each antibiotic were found among four mutants selected in a single CM-s strain. The mutant with the highest CM resistance has the lowest AM resistance, and vice versa, while the level of PM resistance was not correlated with that of either CM or AM. The four mutants all differed from each other in their patterns of resistance to the three antibiotics.

Type
Short Notes
Information
Genetics Research , Volume 6 , Issue 2 , July 1965 , pp. 310 - 315
Copyright
Copyright © Cambridge University Press 1965

References

REFERENCES

Adams, M. H. (1959). Bacteriophages. New York: Interscience Publishers.CrossRefGoogle Scholar
Fisher, R. A. & Yates, F. (1957). Statistical Tables for Biological, Agricultural and Medical Research, 5th ed.Edinburgh: Oliver & Boyd.Google Scholar
Reeve, E. C. R. & Bishop, J. O. (1965). Multi-step resistance to Chloramphenicol in RC-stringent Escherichia coli K 12—its effect on the induction of RNA synthesis by antibiotics under amino acid starvation. Genet. Res. 6, 304–309.CrossRefGoogle ScholarPubMed
Watanabe, T. (1963). Infective heredity of multiple drug-resistance in bacteria. Bact. Rev. 27, 87–115.CrossRefGoogle ScholarPubMed