Hostname: page-component-586b7cd67f-rdxmf Total loading time: 0 Render date: 2024-11-23T07:18:18.964Z Has data issue: false hasContentIssue false

Unifactorial inheritance of warfarin resistance in Rattus norvegicus from Denmark

Published online by Cambridge University Press:  14 April 2009

J. H. Greaves
Affiliation:
Pest Infestation Control Laboratory, Ministry of Agriculture, Fisheries and Food, Hook Rise South, Tolworth, Surrey
P. B. Ayres
Affiliation:
Pest Infestation Control Laboratory, Ministry of Agriculture, Fisheries and Food, Hook Rise South, Tolworth, Surrey
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Wild populations of the Norway rat, Rattus norvegicus, in Jutland have been known to be resistant to the anticoagulant rodenticide warfarin since 1962. The inheritance of the resistance was investigated in the F1, backcross and intercross. The results are consistent with the resistance being due to a major gene at the Rw locus. Resistant homozygotes, heterozygotes and susceptible homozygotes appeared to be distinguishable experimentally on the basis of differences in their susceptibility to vitamin K deficiency. The results are discussed in relation to previous studies of the inheritance of warfarin resistance in rats.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1977

References

BEFERENCES

Bell, R. G. & Caldwell, P. T. (1973). Mechanism of warfarin resistance. Warfarin and the metabolism of vitamin K1. Biochemistry 12, 17591762.CrossRefGoogle Scholar
Brodie, J. (1976). Anticoagulant resistant rats (Rattus norvegicus) in Scotland. International Peat Control 18, 710.Google Scholar
Carter, T. C. & Falconer, D. S. (1951). Stocks for detecting linkage in the mouse and the theory of their design. Journal of Genetics 50, 307323.Google Scholar
Drummond, D. C. & Wilson, E. J. (1968). Laboratory investigations of resistance to warfarin of Rattus norvegicus Berk. in Montgomeryshire and Shropshire. Annals of Applied Biology 61, 303312.Google ScholarPubMed
Finney, D. J. (1949). The estimation of the frequency of recombinations. I. Matings of known phase. Journal of Genetics 49, 159176.CrossRefGoogle ScholarPubMed
Greaves, J. H. & Ayres, P. (1969). Linkages between genes for coat colour and resistance to warfarin in Rattus norvegicus. Nature 224, 284285.CrossRefGoogle ScholarPubMed
Greaves, J. H. & Ayres, P. (1973). Warfarin resistance and vitamin K requirement in the rat. Laboratory Animals 7, 141148.CrossRefGoogle ScholarPubMed
Greaves, J. H. & Ayres, P. B. (1976). Inheritance of Scottish-type resistance to warfarin in the Norway rat. Genetical Research 28, 231239.CrossRefGoogle ScholarPubMed
Hermodson, M. A., Suttie, J. W. & Link, K. P. (1969). Warfarin metabolism and vitamin K requirement in the warfarin resistant rat. American Journal of Physiology 217, 13161319.Google Scholar
Jackson, W. B., Brooks, J. E., Bowerman, A. M. & Kaukeinen, D. (1973). Anticoagulant resistant in Norway rats in U.S. cities. Pest Control 41, 5658, 6064, 81.Google Scholar
Lund, M. (1964). Resistance to warfarin in the common rat. Nature 203, 778.CrossRefGoogle ScholarPubMed
Lund, M. (1967). Warfarin-resistant rats in Denmark. European and Mediterranean Plant Protection Organisation. Report of the International Conference on Rodents and Rodenticides,Paris 1965, pp. 4957.Google Scholar
Lund, M. (1968). Government Pest Infestation Laboratory Annual Report, 1967, p. 70.Google Scholar
Lund, M. (1969). Resistance to anticoagulants in Denmark. Schriftenreihe des Vereins für Wasser-, Boden- und Lufthygiene, no. 32, pp. 2738.Google Scholar
Lund, M. (1972). Rodent resistance to the anticoagulant rodenticides, with particular reference to Denmark. Bulletin of the World Health Organization 47, 611618.Google Scholar
Robinson, R. (1965). Genetics of the Norway rat. Oxford: Pergamon Press.Google Scholar