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Unifactorial inheritance of warfarin resistance in Rattus norvegicus from Denmark

Published online by Cambridge University Press:  14 April 2009

J. H. Greaves  and
P. B. Ayres
J. H. Greaves
Affiliation:
Pest Infestation Control Laboratory, Ministry of Agriculture, Fisheries and Food, Hook Rise South, Tolworth, Surrey
P. B. Ayres
Affiliation:
Pest Infestation Control Laboratory, Ministry of Agriculture, Fisheries and Food, Hook Rise South, Tolworth, Surrey
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Summary

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Wild populations of the Norway rat, Rattus norvegicus, in Jutland have been known to be resistant to the anticoagulant rodenticide warfarin since 1962. The inheritance of the resistance was investigated in the F1, backcross and intercross. The results are consistent with the resistance being due to a major gene at the Rw locus. Resistant homozygotes, heterozygotes and susceptible homozygotes appeared to be distinguishable experimentally on the basis of differences in their susceptibility to vitamin K deficiency. The results are discussed in relation to previous studies of the inheritance of warfarin resistance in rats.

Type
Research Article
Information
Genetics Research , Volume 29 , Issue 3 , June 1977 , pp. 215 - 222
Copyright
Copyright © Cambridge University Press 1977

References

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